Conserved Protein Domain Family
RdRP_2

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pfam00978: RdRP_2 
RNA dependent RNA polymerase
This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses
Statistics
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PSSM-Id: 395779
Aligned: 36 rows
Threshold Bit Score: 318.045
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q86924 2039 MVEGSVScLDTATFCPAKLRSFP-KTHSYLEPTLRSAVPSAFQNTLQNVLSAATKRNCNVTQMRELP-VLDSAVFNVECF 2116 Aura virus
P03594  256 NGDYSMD-FDRIRLKQSDVDWYR-DPDKYFQPKMNIGSAQRRVGTQKEVLTALKKRNADVPEMGDAInMKDTAKAIAKRF 333  Brome mosaic virus
P20179  267 LGDYNVD-ISKLSVRQSDVDWYR-DPEKYYEPELSIGSFQRRIGTQKTVLTALKKRNADVPELADSVdIKRVACEVAEKF 344  Cowpea chlorotic mo...
P27462  271 SADFSSD-FQRLKIKQSHVDWYK-DPDKFFEPVLNFGASSRRVGSQKTVLTALKKRNADVPELSDVVd----ATEVPICL 344  Broad bean mottle v...
Q83944  310 SDDFTVDfPTQVRLRERDEDWFRrKPD-FAVSSIRTGLEMPRIATKKEMLMAFSKRNVGAPQMVEVP-QEIHVKRLADRF 387  Olive latent virus ...
Q66107  228 TQDISLE-VSKCWLDASNFKDFTkGQQTYAVPAYQSGATSKRVNTQRETLLAVKKRNMNIPELQSTFdLDAEVATCFKRF 306  Citrus leaf rugose ...
P89678  253 THDIDLE-VTSCDLDMSTFNDWTkGVDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFdHDDVLNRCVTRF 331  Tobacco streak viru...
P03593  318 TSDKSLD-VDPCRIDLSVFNNWQ-SSENCYEPRFKTGALSTRKGTQTEALLAIKKRNMNVPNLGQIYdVNSVANSVVNKL 395  Alfalfa mosaic viru...
Q9QGG9  363 TSDIALE-LDRATLDTSVFNDWTkSSGPKLNGLFRTGNMSKRIPTQREAALAIKKRNLNVPDLQQVLfEDDEARKIANRF 441  Apple mosaic virus
Q05983 1234 VGPMSLQ-VGSIRWDVSKISPRLfTNNKFAVPHLPTGALLRRNTSSRQVGLAIEKRNANVMNSQKYFdLENLANKAVERF 1312 Raspberry bushy dwa...
Q86924 2117 KKYACNTDYWEefkEKPIRITTECVTSYVARLKGPEAAALfaKTHQLVPLQEVPmdRFVMDMKRDVK--VTPGTKHteER 2194 Aura virus
P03594  334 RSTFLNVDGEDc--LRASMDV---MTKCLEYHKKWGK-HM--DLQGVNVAAETDlcRYQHMLKSDVKpvVTDTLHL--ER 403  Brome mosaic virus
P20179  345 KRAYLNHSGIGl--LGQSMDV---MSRGLEYHKKWKD-HK--DLTGVTVLSEINlqRYQHMIKSDIKpvVSDTLHL--ER 414  Cowpea chlorotic mo...
P27462  345 RQSYLNIYGADc--LFESFNI---MAKGLDYHKRWKS-HK--ELQGVTLLCETNlqRYQHMIKSDVKptVTDTLHV--ER 414  Broad bean mottle v...
Q83944  388 FRTFLKEGGWD-----KGD-----GHYWDDFFHRKGRKVF--SLENCYDDPLSS---YLVMLKSAGKfsLDLNFP---VR 449  Olive latent virus ...
Q66107  307 CTHVVDIPRSKr--LPQMLGT--EIQFFSDYLAGKNP--P--LSEYQGPLTLQSldKYMHMVKTIVKpvEDNSLKF--ER 376  Citrus leaf rugose ...
P89678  332 ITHVVDKTRLSk--LNPISGE--ELHYFNQYLENKNP--P--LSEYKGPVPLVAldKYMHMIKTTLKpvEEDNLHI--ER 401  Tobacco streak viru...
P03593  396 LTTVIDPDKLCm--FPDFISE-GEVSYFQDYIVGKNP--D--PELYSDPLGVRSidSYKHMIKSVLKpvEDNSLHL--ER 466  Alfalfa mosaic viru...
Q9QGG9  442 INTVIDPNKLAq--FPGYISE-GEMGYFNKYLSGKNI--P--EDAFVDPCALVSmdKYRHMIKTQLKpvEDCSQIF--ER 512  Apple mosaic virus
Q05983 1313 FDFFIDMEKFS------KLPTGVLGSSAEQIQTYQNKTGN--KVTDPVCVALSPiqKYKHMIKRDVKfnLTDGAQS--EY 1382 Raspberry bushy dwa...
Q86924 2195 PKVQVIQAAEPLATAYLCGIHRELVRRLTAVLLPNIHTLFDMsaedFDAIIAANFSYVHP-----VLETDIGSFDKSQDD 2269 Aura virus
P03594  404 AVAATITFHSKGVTSNFSPFFTACFEKLSLALKSRFIVPIGK----ISSLELKNVRLNNr----yFLEADLSKFDKSQGE 475  Brome mosaic virus
P20179  415 AVAATITFHGKGVTSCFSPYFTACFEKFSKALKSRFVVPIGK----ISSLELKNVPLSNk----wFLEADLSKFDKSQGE 486  Cowpea chlorotic mo...
P27462  415 DVPATITFHGKGVTSCFSPFFTACFEKFSLALRESIYVPIGK----ISSLELKSKALNNk----fFLEADLSKFDKSQGE 486  Broad bean mottle v...
Q83944  450 SVPQTITYHEKWVTEVFSPMFLQVMARFFSRLQDWVVVPAGP-----MADFSRVWPSFEGk---cLTEIDLSKFDKSQGK 521  Olive latent virus ...
Q66107  377 PLCATITYHKKGIVMQSSPLFLSAMSRLFYVLKSKIHIPSGK----WHQLFTLDAAAFDAak--wFKEVDFSKFDKSQGE 450  Citrus leaf rugose ...
P89678  402 PIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGK----YHQIFQMNPELLKHsk--eFKEIDFSKFDKSQGR 475  Tobacco streak viru...
P03593  467 PMPATITYHDKDIVMSSSPIFLAAAARLMLILRDKITIPSGK----FHQLFSIDAEAFDAsf--hFKEIDFSKFDKSQNE 540  Alfalfa mosaic viru...
Q9QGG9  513 PLASPITYHDKGKVMSTSPILVMMCNRLLLCLTEKISIPTGN----ISLFSLDPFASEMTk---eFKEIDPSTFDKSQQR 585  Apple mosaic virus
Q05983 1383 TKAATITYHQPEITQVATAIFGQFKTRLLACRNKFLNIPLEH----DNDLSGYLTKYHLGsenntFTEIDFSKFDKSQGE 1458 Raspberry bushy dwa...
Q86924 2270 SLALTALMILEDLGVDDRLMDLiECAFGEITSVhlptaTTFKF--GAMM------KS--GMFLTLFVNTVLNVVIASRVL 2339 Aura virus
P03594  476 LHLEFQREILLALGFPAPLTNW-WSDFHRDSYL-----SDPHA--KVGMsvsfqrRT--GDAFTYFGNTLVTMAMIAYAS 545  Brome mosaic virus
P20179  487 LHLEFQREILLSLGFPAPLTNW-WCDFHRESML-----SDPHA--GVNMpvsfqrRT--GDAFTYFGNTLVTMAMMAYCC 556  Cowpea chlorotic mo...
P27462  487 LHLEFQRLILINLGFPVPLTNW-WCDFHR-SIL-----SRWTLrpGVSIpl--lsKTnrG-CFHLLWEHFSDNAMMAYCF 556  Broad bean mottle v...
Q83944  522 LLHDVQREIFLRLGFPPIWCDW-WFKFHESSYL-----NDKNL--GIAFsvdyqrRT--GNTATYFGNTLVTMIMMAEVY 591  Olive latent virus ...
Q66107  451 LHHKVQKMIFDLLKLPPEFVEM-WFTSHERSYI-----TDRDT--GVGFavdfqrRT--GDANTYLGNTLVTLICLARVY 520  Citrus leaf rugose ...
P89678  476 LHHDVQFRLFLALGIPEHFVTT-WFNSHEKSYI-----RDRDC--GIGFsvdyqrRT--GDACTYLGNTLVTLSVLSYVY 545  Tobacco streak viru...
P03593  541 LHHLIQERFLKYLGIPNEFLTL-WFNAHRKSRI-----SDSKN--GVFFnvdfqrRT--GDALTYLGNTIVTLACLCHVY 610  Alfalfa mosaic viru...
Q9QGG9  586 LHHLTHYHTPTALGAPADFIDM-WFGSHEISHI-----RDGPC--GVGFsvnyqpRT--GDACTYLANTIITLSALAYMY 655  Apple mosaic virus
Q05983 1459 IHQLIQDLILIKFGCDPEFVAL-WSTAHRSSSI-----FDQNV--GIGFktdfqrRT--GDAFTFLGNSLVTAAMLAFVI 1528 Raspberry bushy dwa...
Q86924 2340 EqrLR---DSKCAAFIGDDNIIHGVVS-DKIMADRCATWMNMEVKIIDAVIgikaPYFCGGFILEDQVTHt---aCRVSD 2412 Aura virus
P03594  546 D--LS---DCDCAIFSGDDSLIISKVK-PVLDTDMFTSLFNMEIKVMDPSV----PYVCSKFLVETEMGNl----VSVPD 611  Brome mosaic virus
P20179  557 D--MN---TVDCAIFSGDDSLLICKSK-PHLDANVFQSLFNMEIKVMDPSL----PYVCSKFLLETEMNNl----VSVPD 622  Cowpea chlorotic mo...
P27462  557 D--MS---TAELAMFSGDDSLVICGSK-PEFDPGVFQSLFNMEVKVMDPSL----PYICSKFLLESEFGDv----FSVPD 622  Broad bean mottle v...
Q83944  592 E--LDs--LPFCGLFSGDDNLIVTDRP-LEGRVSLFPNMFNMEAKVMRPGQ----NYMCSKYLCTVDGRV-----TPVPD 657  Olive latent virus ...
Q66107  521 D--LCd-pKITFVIASGDDSLIGSVEElPRAPEHLFTSLFNFEAKFP-HNQ----PFICSKILVSVDLVCggrevIAVPN 592  Citrus leaf rugose ...
P89678  546 D--LSn-pNILFVAASGDDSLIGSIEPlPREKEDLCVSLFNFETKFP-HNQ----PFICSKFLLVVECDDgseevLAVPN 617  Tobacco streak viru...
P03593  611 D--LMd-pNVKFVVASGDDSLIGTVEElPRDQEFLFTTLFNLEAKFP-HNQ----PFICSKFLITMPTTSggkvvLPIPN 682  Alfalfa mosaic viru...
Q9QGG9  656 D--LLd-pNITFVIASGDDSLIGSRVPlDRDDEFKFTTLFNFEAKFP-HNQ----PFVCSKFLCLVPTTDggkkvVAVPN 727  Apple mosaic virus
Q05983 1529 S--DPdreKIRYMLVGGDDSLICSYGP-IQVPLEPLGDIFNMSCKLVQPAC----PYFASRYLIRRGDEI-----LCVPD 1596 Raspberry bushy dwa...
Q86924 2413 PLKRLFKLGKPLPVDdE-QDHDRRRALEDETRAWFRvGIQGELLKAVESRYEVQ--EVQPVLLALATFSRSDKAFKAL 2487 Aura virus
P03594  612 PLREIQRLAKRKILRdEqMLRAHFVSFCDRMK-FINqLDEKMITTLCHFVYLKYgkEKPWIFEEVRAALAAFSLYSEN 688  Brome mosaic virus
P20179  623 PMREIQRLAKRKIIKsPeLLRAHFESFCDRMK-FLNkLDEKMINLLCKFVALKY--KKPDVENDVRVAIAAFGYYSEN 697  Cowpea chlorotic mott...
P27462  623 PMREIQRLQKRKIPKdVqVLRADFDSFCDRMK-FLDrLSELSLSVLCRLTALKY--CKPGIEGDVRAWLSGFAYYREN 697  Broad bean mottle virus
Q83944  658 PFKLLKKAGASCPLE---HLDDFYESFLDYTKYLVRdEVRTLIPRLMAHRYQVSmdEAGVALDQIMSWRKSKTQFFKH 732  Olive latent virus 2 ...
Q66107  593 PAKLLIRMGRRDCQYq--ALDDLYTSWLDVIYYFRDsRVCEKVADLCAYRQTR------RSSMYLLSALLSLPSCFAN 662  Citrus leaf rugose virus
P89678  618 PLKLLQKLGPKNLQVt--VLDDYYQSLCDILWVFNDaDVCRRTAELAEYRRFKGt----KKCLFLESALLSLPSLVAN 689  Tobacco streak virus ...
P03593  683 PLKLLIRLGSKKVNAd--IFDEWYQSWIDIIGGFNDhHVIRCVAAMTAHRYLR------RPSLYLEAALESLGKIFAG 752  Alfalfa mosaic virus ...
Q9QGG9  728 ALKLNIKLGVKDLSPl--TFDSWYESWLDLIWYFDNyLIVSTMKDYLSHRYLR------KPTMFQEGAMLAYGSIFAN 797  Apple mosaic virus
Q05983 1597 PYKLLVKLGRKDVPDnQaSLCEIRTGLADSAKYIFDdIVKQKLAILVQVRYNKAapSLYDALCTVHWALSSNTNFSKF 1674 Raspberry bushy dwarf...
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