Conserved Protein Domain Family
RT_nLTR_like
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cd01650: RT_nLTR_like 
RT_nLTR: Non-LTR (long terminal repeat) retrotransposon and non-LTR retrovirus reverse transcriptase (RT). This subfamily contains both non-LTR retrotransposons and non-LTR retrovirus RTs. RTs catalyze the conversion of single-stranded RNA into double-stranded DNA for integration into host chromosomes. RT is a multifunctional enzyme with RNA-directed DNA polymerase, DNA directed DNA polymerase and ribonuclease hybrid (RNase H) activities.
Links
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Statistics
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PSSM-Id: 238827
Aligned: 98 rows
Threshold Bit Score: 108.147
Created: 10-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputativeputative NTP
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based primarily on the structure of the stalled complex of HIV-1 RT bound to NTP and DNA primer-template (1RTD).
  • Citation:PMID 9831551
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
AAD08951      777 STILALIPKrtyak----emkdYRPISCcnvlYKAISKLlaNRLKCLLPEfia-----pnQSAFISDRLl---------- 837  thale cress
AAA21792      499 DAKVVVLKKpgksaaqqklagaWRPISLlsnvGKILEALvaKRLTQAAEEfnll---pegQMGNRAGRStefav---rvv 572  Neurospora cr...
BAC82597      120 QGRTILIYKkgdkl----dtqnYRPITClnclLKVYTSIlkMKIENQLMLnpiekqlslnQIGCKKYTYaskegllynti 195  Entamoeba his...
BAE66176      504 HAKIIPLKKpnkeny--tiaksWRPISLlatlGKVLESVvaERISHAVEThgll---ptsHFGARKQRSa---------- 568  Aspergillus o...
AAB71689      491 KAEVAMLPKtgkkdr--ssvrsWRPIALlsciGKGLERLvaRRIAWAIHDngll---sctHGGALPKRSa---------- 555  Magnaporthe g...
CAA67543      138 TGAIVPKPKkadyt----avksYRIVSLlncmGKVAEKLvaFRLAQLCEDksll---htgQMGGRKHRSs---------- 200  Ascobolus imm...
XP_001203833  245 VAEGVYIPKsatpne--ktitdFRPIALlnveAKMFFAIpaKRLETYMRKngyl--dttvQKGGVGGHPgv--------- 311  purple urchin
XP_684355     338 CAEGVWIPKeensk----ninqFRIISLlsveGKVFFSIvsRRLTEFLLEnnyi--dpsvQKGGIPGAPgcleh--tgvv 409  zebrafish
EAU90697      525 DSITCVLRKpgkpdy--qipkaYRPIALlsttAKLLSATvaDDMTRIIEVngll---pknHFGGRPGRTt---------- 589  Coprinopsis c...
EAU86808      271 EWTTVVLKKpgkpry--dtpkaWRPIALmntmGKILTALltEDLKYVTEKysll---pntHFGGRPGRTt---------- 335  Coprinopsis c...

Feature 1                                    ######                                               
AAD08951      838 mENLLLASELvkdyhkdglsprcaMKIDLSKAF-----DSVQWPFLLNTLaaldipekfihwin------------lcis 900  thale cress
AAA21792      573 tDAVHTAWKLgav--------tslMLLDLKGAF-----DRVNHRWLLHTLwemqlptwiirwvasfvag-rrgslffdde 638  Neurospora cr...
BAC82597      196 iNQLLLKTKWkw----------veTYYDVSKAY-----DSINHQWIKQCLiyfnillvvinsilyilnn-tylnlyynqe 259  Entamoeba his...
BAE66176      569 eQALVLLQEQiyaawrg-rrvlslISFDVKGAY-----NGVCKERLLQRMkargipedllrwveafcsertatiqingql 642  Aspergillus o...
AAB71689      556 tDLVCALAHDieqalar-geevtlVACDVQGAF-----DALLHGRLIRKMrslgfskmllrfvinflsg-rqarvrlegt 628  Magnaporthe g...
CAA67543      201 qDAVMALVHDielgwsr-gltssaLLLDVKGAF-----DNVSKVRLLESSgmripkplvewvssfmsdr--lialafdgs 272  Ascobolus imm...
XP_001203833  312 wEHVATLWEVikdakts-qknlvaIWLDLANAF-----GSVPHAAIAFALkwyhlpeslvslmnnyyvg-lyarfsvkdw 384  purple urchin
XP_684355     410 tQLIREAHENrgd--------lvvLWLDLANAY-----GSIPHKLVELALhrhhvpskikdlildyynn-fkmrvtsgse 475  zebrafish
EAU90697      590 tDALHYLVGKvkkawre-kkvvsiLYLDVEGAFpnavtDRVIHNLRIRRIpevyvrliakmlegrrt------klrfddf 662  Coprinopsis c...
EAU86808      336 tDAIQLLTSWikghwrk-gnvvsvLFLDIEGAF-----PNVVVSRLAHNMrrrrvpefivkliehqlrd-rrtklkfddy 408  Coprinopsis c...

Feature 1                     ##                                                      # ##        
AAD08951      901 tasfsvqvnGLRQGCSLSPYLFVICMNVLsamldkgavekrf-----------gyhprcrnmgltHLCFADDIMVFsags 969  thale cress
AAA21792      639 tsrpyaitaGVPQGSPLSPILFILFITPLyrklat-------------------------ipntiTVGFADDTNVVavar 693  Neurospora cr...
BAC82597      260 sdnminverGIIQGDSLSPLLFILSIDVLskqldkqisklni-----------kmngeekqvqlnHILYMDDLKIMt--- 325  Entamoeba his...
BAE66176      643 sevhslpqaGLPQGSPLSPILFLFFNADLvqrqi--------------------------dsqggAIAFVDDFTAWvtgp 696  Aspergillus o...
AAB71689      629 ttgfrrlgcGTPQGSPLSPILYMLYLAYLvkng-----------------------------tkwRLAYADDVLTWks-- 677  Magnaporthe g...
CAA67543      273 keelqpvntGIPQGSPCSPILFLIYLKPLfneler------------------------hklniqTPSYIDDVAIMltgk 328  Ascobolus imm...
XP_001203833  385 nsewqkfsvGIFMGCTLSPILFVITFNLLndflkstpakqy-------------hlkkrdfnvpvMKEYMDDITIItasv 451  purple urchin
XP_684355     476 tsswhrigkGIITGCTISVILFALAMNMVvksaevecrgp---------------ltksgvrqppIRAYMDDLTITtttv 540  zebrafish
EAU90697      663 lsefiaidnGIGQGCPLSMIIYILYNADLleipr--------------------------nededAIGYVDDAILIaian 716  Coprinopsis c...
EAU86808      409 esewvpidnGSGQGDPKSMLEYLFYNADLidlvaglgeeleegengedaprgsarergtekrdenAAAFVDDAWLGgaga 488  Coprinopsis c...

Feature 1                                                                                         
AAD08951      970 a-----hslegVLAIFKDFaa-----------fsGLNISLEKSTlfmasissetcas-------------ilarfpfdsg 1020 thale cress
AAA21792      694 tteencrtlqaAWEVCSEWag-----------arGMEFEATKTElmhftrtraprtet------------lqlgdtvlqp 750  Neurospora cr...
BAC82597      326 ----------nSLDEMEKAhkltke----ifnaiGLKINLEKSGimtnisgkinge---------------ldelprvtn 376  Entamoeba his...
BAE66176      697 taqsnregiegIIKEALHWer-----------rsGATFEAEKTAiihftpktskldre-----------pftikgqavep 754  Aspergillus o...
AAB71689      678 ---------spSLEENVRWledklrdmheiaaeeKIHFAAEKTEvihitkkrhgrnpeiringrtvtpvqlpggrrgqsa 748  Magnaporthe g...
CAA67543      329 stv--knaatlQKAAVIAFewa---------rgnAIAFDDSKSElihfantnkvptcp-----------mvlpngtelrp 386  Ascobolus imm...
XP_001203833  452 e------sagsILSKVNDFmd-----------wsKMRIKPVKSRslvvhggkvkhiepf----------avdgqtipgvh 504  purple urchin
XP_684355     541 pg---srwilqGLERLIAWa--------------RMSFKPSKSRsmvlkkgkvvdkfhf----------sisgsvnptit 593  zebrafish
EAU90697      717 tf----ddtvrILKDMMERegggfq----wstehNSRFELSKLAimhmsrrtreevdgsrvki-hteapplalrgehvki 787  Coprinopsis c...
EAU86808      489 tf---eeanetLKDMMNRR---------------GGAMEWSKKHnskf-------------------------------e 519  Coprinopsis c...

Feature 1               ##   
AAD08951     1021 slpVRYLGLPL 1031 thale cress
AAA21792      751 tesTRFLGVWL 761  Neurospora crassa
BAC82597      377 dnpYKYLGIEI 387  Entamoeba histolytica
BAE66176      755 kdhVKILGVLM 765  Aspergillus oryzae
AAB71689      749 sgaERYPGMRW 759  Magnaporthe grisea
CAA67543      387 lpsVRWLGILL 397  Ascobolus immersus
XP_001203833  505 nkpVKFLGRLI 515  purple urchin
XP_684355     594 eqpVKSLGKLF 604  zebrafish
EAU90697      788 vteYKYLGVVV 798  Coprinopsis cinerea okayama7#130
EAU86808      520 iskLVYMGFTR 530  Coprinopsis cinerea okayama7#130

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