2EPG


Conserved Protein Domain Family
RtcB

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pfam01139: RtcB 
tRNA-splicing ligase RtcB
This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.
Statistics
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PSSM-Id: 460080
Aligned: 247 rows
Threshold Bit Score: 252.817
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EPG_B           56 QLXNVATLP--------GIVEPALAXPDIHWG-YGFPIGGVAAFDpeeGGVVSPGGVGFDINCGVRLLASH-LTLEDL-- 123 Thermus ther...
BAI81751         23 QIYSIVNHP--------VFTGPVRIMPDVHAG-AGCVIGFTAPLT----NKIIPSIIGYDIGCGVSTCILGkIKKEEF-- 87 
CCB85239         79 QMNHAMRLP--------IAVAG-ALMPDAHMG-YGLPIGGVLAVE----NAVIPYAVGVDIACRMMLSVYP-ESPEALrd 143
WP_011322690     22 DLKTVAGIP--------DVER-VIALGDIGPS-KSETPGSIAVAT---TGTVYPEFCSNVVNCGMSLLRTG-LKEEDV-- 85  Natronomonas...
EFC45815        166 QLQDTARTL--------KCVRRATGQPDLHPG-KTFPVGAAISTV----DYIYPPLVGNDIGCGMSLYQTN-LTSDRG-- 229
WP_012239616     31 QLARVAALP--------GCVR-AVGMPDLHAG-RGIPIGAAFAFA----DRVVPALIGGDAGCGVRLVATS--------- 87  Sorangium ce...
WP_015126959     57 QLMNLANVRhp----agGCVCRACATPDFHPGdAGVAIGSVVETV----GQVIPAAVGSDINCGMRLHVAN-LTIDQFla 127 Calothrix sp...
WP_015121855     57 QLANLASVRhp----agGYVCKCHATPDFHPGdAGIAIGSVVQTE----NMVIPAATGSDINCGMRLHVAD-LTIDEFla 127 Rivularia sp...
WP_012207445     51 QLLAFAAVRrhdgqgshGAVCRACATPDFHPG-TVAPVGSVVATP---SDFVIPAAIGTDINCSVRLLTTG-ARLDQLap 125 Delftia acid...
CAS:CtCNB1_2374  80 QLLDFASVAdpq---ghGAVCKACATPDFHPG-SIAPVGAVVATS---PDFVIPAAIGTDINCGIRLLSTG-LTQAQAel 151
2EPG_B          124 ------LPR-QKELA---DALY---RLVPSGV-GserRDVRFS-K---RELKEILKEGAGWL---VKR----GYGYPE-D 177 Thermus ther...
BAI81751         88 ----------LDNWViidKKLR---EIIPLGQnT--------------HEKSSIIKENKKFFediFKSqkqyYLNKISnV 140
CCB85239        144 fhstrhQAFqEVLLA---NTVF---GSGPMGQhE--------------GKIEHPVLEEKHW------------------- 184
WP_011322690     86 ------TDElLTKFC---ERLQspdERFSPDK----------------QDTIGMLEHGAEYV---VDEw---GFSP---D 131 Natronomonas...
EFC45815        230 ----------LKQLEkwvKQLN---GLERGGIsG--------------DESRPVLDVERKFF----------GLDSSE-D 271
WP_012239616     88 ----------IGRMAp--DVLE---RRARQAM-----DDEPLAeCdprAVFERVWERGAR------------GFAEVD-- 133 Sorangium ce...
WP_015126959    128 -----kRDLfVERMK---GDYFfgtRDVTMTA----------------QTMRALFQYGVPGWvdaMLDqp-tGSVVKS-D 181 Calothrix sp...
WP_015121855    128 -----kRNQfVELMK---GDYFfgtRDVTMSG----------------LAMQALFEYGVPGWldvMLDsp-sGSVTKS-N 181 Rivularia sp...
WP_012207445    126 -----hKGRlVELLT---ASLLgsgRDVPVTT----------------AAFRALFDHGPAAFvdrLNGq---GLWGHV-D 177 Delftia acid...
CAS:CtCNB1_2374 152 -----hKSTiVQRLT---RVILqngRDVPVRS----------------AGFKALFDEGPQAFieqLPDv---GLWQGV-N 203
2EPG_B          178 VRFIESQ----------------------------GRLPWA-----------NPDKVSERAFERGAPQIGTLGSGNHFLE 218 Thermus ther...
BAI81751        141 FNKIFKNeklniklekyfsldyifkelpakiglpgGYIFSA---------------------------LGTLGGGNHFIE 193
CCB85239        185 ----------------------------------------------------QGTKLTRGLRQTGIRQIGTSGGGNHFVE 212
WP_011322690    132 LLTNIEN----------------------------GGNMFKtenrtreirelVPPWILSHPNAREDTPIPNL-SGNHFIE 182 Natronomonas...
EFC45815        272 LLSATSTnsenvdfelheattefiekyltyfdvdlGQLQEVtpnleseegvtSPPKSENKALEFAIRQLGTVGGGNHFAE 351
WP_012239616    134 -GAPEAL----------------------------ARLAAAepe-----dglRPSGDASPYRAGYEGALGSVGGGNHFLE 179 Sorangium ce...
WP_015126959    182 LEQLAQEserifl-----------------ggsmdGNWKLA-----------PEELVPDEG-LVRDGSLATIGSGNHFVE 232 Calothrix sp...
WP_015121855    182 LEQLAAEtdnifl-----------------ggsmdGNWQLA-----------PDELVPDEE-LVRDGGLATIGGGNHFVE 232 Rivularia sp...
WP_012207445    178 RDRLHRElaacig-----------------ldsfaGSARHA-----------PHAYLQERHAVFRDPCLGTVGSGNHFVE 229 Delftia acid...
CAS:CtCNB1_2374 204 RDRLQAElaecvg-----------------lqgfaGRSRYA-----------PEALLQARE-LLRPPSAADLGSGNHFLE 254
2EPG_B          219 VQYVDEVYD----EEAALAFGLFKGQ-VTVLIHTGSRGLGHQVCQDYVE--RFL----------KVA----PRYG---I- 273 Thermus ther...
BAI81751        194 VEVN------------------ESDD-LFVTIHTGSRNLGKKIAEYWQKkaIAScrtgnkdrfkKEIellkMKYKgkdLe 254
CCB85239        213 WGEL----Ei---GSSENPLGLQVGKyVALLSHSGSRGVGAKIADHYTKwaMEQmpt-----leQSV------------- 267
WP_011322690    183 FQVVDEVLD----SDTATEWGLSEGD-VLVAMH-GDYQLTLYINWHYANrhKFRehaalqdkikLQL----SKLLfhaWs 252 Natronomonas...
EFC45815        352 LQIVEKICNekifEEELKL---SKDA-CFLMVHSGSRSLGDHILGEHED--KFG-------------------------- 399
WP_012239616    180 VARVGALRD----PAAAKALGLSAGE-LVVVAHSGSRGLGGALG---------------------------QRWG----- 222 Sorangium ce...
WP_015126959    233 VQQVDQVEN----RALAHAWGVREGQ-MAFMIHSGSRNVGKYIGGMWRD--RSQ-----------------AAWP---Kg 285 Calothrix sp...
WP_015121855    233 VQRVDKVIN----SALAYAWGIKEGQ-IAFMIHSGSRHVGKYIGGMWRD--KAV-----------------SAWE---Ag 285 Rivularia sp...
WP_012207445    230 LQVVDEVLD----RHAAYRAGLRAGD-VVVMIHSGSRDLGFYVGQAWMD--RAR-----------------AEWP---Qg 282 Delftia acid...
CAS:CtCNB1_2374 255 FCVVDEVYD----RHAAYAAGLKKGD-VTVMIHTGSRDVGFYVGRRWMD--LAR-----------------QQWP---Qg 307
2EPG_B          274 -ELVD-----------KQLAAAPIKS--PEGQDYLQAXAAAANFAFANRQLIAHFVREAF---EKV-GFTP--RdhglrV 333 Thermus ther...
BAI81751        255 nAINDlkvkyknnnfsQELSYLSSPS---DVAGYLIDMFIAQIFATYNRYCIYNFVEQII---SYIlKKDN--N-----L 321
CCB85239        268 ----------------RHLAWLPLDS--EAGLEYWDAMQLAGKFASANHHVIHQRISQAL-------------------- 309
WP_011322690    253 gRVRDlpqnwkcyngsERFSGIDTNT--VQGDRYVQTQHAAMNFGYANRLLANCYMADVL---ADItSKASdaS-----L 322 Natronomonas...
EFC45815        400 ----N-----------SGLL---FDS--DDAKHYMKCHDNACRWAKANRALIARKFLTCIngnGKMi------------- 446
WP_012239616    223 --------------------GAVLEG--DAAEPYLGELAGACRFARANRLLLAYRMLRALgasRAStITGG--------- 271 Sorangium ce...
WP_015126959    286 lKYPD-----------ANIFPLSTHShpQLVASYLQAEATAANYGFVNRLLLAELLRLRL---REVyGDIEa-P-----L 345 Calothrix sp...
WP_015121855    286 vKYPD-----------SKIFPLSLNShpELVAGYLQAEATAANYGFMNRLLLAELLRLRL---REVyGDVEa-P-----L 345 Rivularia sp...
WP_012207445    283 vKHPA-----------SGLYGLSG----PLAGEYLQAMGVAARYAWANRVVLAELVRKDL---EQIvGAADs-R-----L 338 Delftia acid...
CAS:CtCNB1_2374 308 iKHPQ-----------HGLYGLSG----ALAQDYLQAMGVAARYGWFNRMALAELVRKEL---AGIaASDAs-R-----L 363
2EPG_B          334 L--------YDLAHN--NAKF-E----EH-RgRRVLVHRKGATRAfgpghpevpeeyrRVGQPVLVPGDXGRYSYVLAGT 397 Thermus ther...
BAI81751        322 LlddlvlnsFESVHN--YVDFdD------------LIIRKGAIKT-------------PIGKEIIIPLNMKDGVIIAKVK 374
CCB85239        310 Gltp--ltsVENHHN--FAWK-EsviiDGiE-KEWIVHRKGATPA-------------GKDVLGIIPGTMADVGFLVRGK 370
WP_011322690    323 L--------WDVGHD--TLQR-Esi----gG-EEYWIHRKAAGNA-------------AAGKPAFISGSYNMDSFL--GQ 371 Natronomonas...
EFC45815        447 ---------LDICHNnvVEKQvE-------N-ERVFIHRKGAAPT-------------DAGY-FCIPGSRGSFSYLVRGR 495
WP_012239616    272 ---------LDLTHN--DVAR-Eav----gG-ELAWVHRKGAAPA-------------RGSDFTVVLGSRGAPSWVMRSC 321 Sorangium ce...
WP_015126959    346 V--------YDLPHNitLPEK-----------PGSWVTRKGACPA-------------HAEQPVIIPGSMGAYSYLMVGK 393 Calothrix sp...
WP_015121855    346 V--------YDLPHNitLPVEsK---------ISRWITRKGACPA-------------NLGQPVIIPGSMGAYSYLCVGK 395 Rivularia sp...
WP_012207445    339 V--------VDVPHN--VVLQ-Q---------GGMNIHRKGATPA-------------NEGDFALIPGSMGDASYLVTGL 385 Delftia acid...
CAS:CtCNB1_2374 364 I--------VDVPHN--VVMT-E---------GEFNVHRKGSTPA-------------HDGQWALIPGSMGDYSFLVKGL 410
2EPG_B          398 E---KAXe-VSFGSSCHGAGRKXSRHQAKKVARERNLVKEL---AERGILVRAATRATVDEEXPEAYKDVSLVVEAVEGA 470 Thermus ther...
BAI81751        375 NepiKLIe-RNF-SAPHGAGRKMSRSKAKQSINLNDFRKSMvgiASSSV------NETTLDESPMAYKDKDNIITYLN-- 444
CCB85239        371 G---HAA---ALNSASHGSGRQMSRTRAKQNITSEQHAAYL---SQRGVKLI----GGGLDEAPQAYKPIEQVIEAQS-- 435
WP_011322690    372 G---LPGaeAYLNSYDHGSGNVISYFESNGQLPKT----DL---STAKYSLQEARDSDKIKHIDR--KPIERLADNVTGK 439 Natronomonas...
EFC45815        496 EediESQirCNF-SAAHGAGRKWKRSKSVGMAAKENVQSFTv--TDLGSHVICEDKNLLFEEQPAAYKDIDAVISDLVHF 572
WP_012239616    322 D---AEA---GLRSVAHGAGRKMGRSEAREKIAARYRRRELa-rTELGGRVVCDDPALLLEEHPDAYKPIEPVIESLVEA 394 Sorangium ce...
WP_015126959    394 G---NPT---FCNSASHGAGRIRSRFDLNRR-GASQNEDEL---GLTGVDCITLRSERRIEEAPAAYKPIQSVIDVQVEA 463 Calothrix sp...
WP_015121855    396 G---NHK---FANSASHGAGRLRSRFELSRG-GARETEEEL---GLTGVDCITLREERRIEEAPAAYKPIDSVIDVQLKA 465 Rivularia sp...
WP_012207445    386 G---AAD---WLWSCSHGAGRRMRRQAVRA-LRPEAHAGRA---GEQGWQCVTLREERRIEEAPEAYKPIGPVIESQEAA 455 Delftia acid...
CAS:CtCNB1_2374 411 G---HED---WLRSCSHGAGRQVRRQDTRRM------KQPL---VESVWQCITLREERLIEEAPSAYKPVGPVLQAQEEA 475
2EPG_B          471 GIGKKVARLRPLIVVKG 487 Thermus thermophilus HB8
BAI81751        445 NIADIVYILKPIYVLKD 461
CCB85239        436 DLVEVLGVFQPRIVRMA 452
WP_011322690    440 GILSGVAWLRPIANIGE 456 Natronomonas pharaonis
EFC45815        573 GVVEVVAIMRPLITYKM 589
WP_012239616    395 GLATPVAPLVPVLTVKR 411 Sorangium cellulosum
WP_015126959    464 EMVGLVARLSPVLTFKV 480 Calothrix sp. PCC 7507
WP_015121855    466 GIVDVVARLSPILTFKA 482 Rivularia sp. PCC 7116
WP_012207445    456 GLIHAAVKLRPWITFKA 472 Delftia acidovorans
CAS:CtCNB1_2374 476 GLIRASVRLKPWLTFKA 492
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