6BBG


Conserved Protein Domain Family
Orai-1

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pfam07856: Orai-1 
Mediator of CRAC channel activity
ORAI-1 is a protein homolog of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.
Statistics
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PSSM-Id: 462291
Aligned: 29 rows
Threshold Bit Score: 102.717
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BBG_A           14 LSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLd----hDTN-VPPGMLIAFAICTTLLVAVHMLALMISTCILPNI 88 
XP_002900392     61 SEKRLIDARHQQLQTVSQLSAMMAFFSIMFIQEIKSlq------sdTSDPLIIIYGTVGVLEFLCMLLCTLTCTLLLLAL 134
EED95370         38 DARRAVDEKAQQLKVLANQSALVAGFSMVVLVESNIpp-------dINGALLTLFGGVTACVIALMLVSTLNATYMLVAI 110
XP_002970256     86 KNRRDVEEKSEQLKAISNLAALFAGFAVVTLTQFTIap------dpVLTVWIAFYGVLTAIAVGLMTISMVTCTLILGSI 159
EFJ26564         27 LNRRDVEEKSEHLRSLSWITGLVTSFTMTAPVEFNTpk-------sIRAGRLMPYAICTAIVPTLMTTSTIICVYLLGCI 99 
jgi:OSTLU_33356  96 KNRRDVEEKGEQLRTTSNLSALISGFAVVALVELQFsdptvkAF--QSEALIAAYAGATAVTVALMLNAMVLCSFMLSNI 173
XP_002506166     94 KNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFsdpnetPE--RNEGLIVAYAATTALVVALMLNSMVLCSFMLCSI 171
EEH58374         93 KNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFhdpetrPS--QSEALITAYAATTALTVGLMLNSMVLCSFMLCSI 170
XP_004993864      6 arRRQLALFTHKLEQTGGTSALLSGFALVAMVELNLpegrthVEEfDNNPVFYIFSAVTSVLIALHLFALMVSTSVLPYL 85 
OZF95390        103 SEKYNYDLSKAQLKASSRTSALLAGFAMVCLVELQYde-------kTSKPLLIVLGVVTSLLVSVHLLALMMSTCILPYM 175
6BBG_A           89 ETV------SNLHSIS--LVH------------------ESPH-----------------------------ERLHWYI- 112
XP_002900392    135 TRFvthtldGEVRQLSdgELDt-------------------------------------------------vSPFTDWWt 165
EED95370        111 LRYdcv-------------------------------nrEVP--------------------------------FDEFWr 127
XP_002970256    160 LKN------GKSYVNEeaEEEfmfkcrdfvksyrtgdkpPSPR-----------------------------RTFEAFWe 204
EFJ26564        100 LRM------GKSFVSEhaEEEfmalchsyaesaapsqppPVPS-----------------------------RTFQNFWa 144
jgi:OSTLU_33356 174 LRN------GKSYVSEdeEAEflyacrkfalsyapgdtpPQPQ-----------------------------RSFERYWe 218
XP_002506166    172 LRN------GKTYVSDeeEADylfrcrrfahefklgdapPRPH-----------------------------RSFERHWe 216
EEH58374        171 LRN------GKTYVSEdeEAEylyrcrrfaleftsgdkpPLPK-----------------------------RSFERHWe 215
XP_004993864     86 KSA--------IEDIDhhLAQralta---------rakgQALHnligpqdtlfddttdtshdngllervkhlDQFSSYI- 147
OZF95390        176 EAT------GCTQ--------------------------DSPH-----------------------------LKLKFYI- 193
6BBG_A          113 ---ETAWAFSTLL---G------LILFLLEIAILCWVKFYDLSPp--AAWSATVVLIPVMIIFMAFAIHFYRSLVSHKYE 178
XP_002900392    166 fkcEQEWLLAYHLfrtG------ASFFLVAVSLASWIVLVRSTA---ASVVVSVLCVCGLLYYNLRIASRWRYLVKPSTS 236
EED95370        128 krcEPDWKMALRTfsyG------IPLFMVVVALVAWVSFWDHESlyySASVVTAISVMVLILWFGSTERKWGEFLRMSDA 201
XP_002970256    205 ircEDDWKRAFQFfawGrplnsrVLSFLFSLIPIGWIKFY--NSr-lTAGLFMGVIAVSIIVWG-FVQYLWGGYLTKTfr 280
EFJ26564        145 arcKDYWNTAFSLffwG------VSFFLALLCTMGFIKF---SDd-rVALSFTTVIGISFVAWL-GIQVKWGYYLKKEYE 213
jgi:OSTLU_33356 219 trcEADWRKAFRMftyG------VPMFLTTLTLSAWLKFW--YSt-vTCSIVTGVAAVAIGLWW-RTQSAWGWHLMKRSE 288
XP_002506166    217 trcEDDWRHAFRMftcG------VPVFLVNVSCMSWLKFH--YSp-lASWTVTAIAAVASLGWL-HTQNNWGFHIAKSQA 286
EEH58374        216 trcEDDWRHAFRMftcG------VPVFMVNIACMAWLKFN--YSy-aAAGTATAVAVCATAGWA-RTQMNWGWHISRRYH 285
XP_004993864    148 ---SKAWFFANGV---G------IALFLLQLALISYIKFLAHTPg--AGWTGVGTLSPAFVLFMVFIYRFYRKIVGSQst 213
OZF95390        194 ---DLSWLFSTCI---G------LLLFLVEIGVIFYVKFTAVGYp-tAGYITTAMLVPVGIVFVLFSYLIHKNRVSHSLG 260
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