6TF9,7AS4,6TF9,6V69,3RIP


Conserved Protein Domain Family
GCP_C_terminal

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pfam04130: GCP_C_terminal 
Gamma tubulin complex component C-terminal
This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains.
Statistics
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PSSM-Id: 461187
Aligned: 232 rows
Threshold Bit Score: 123.502
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TF9_QP1      554 LLEHMQAMRRYLLLGQGDFIRHLMDLLKPEL------VRPATTLYQHN---LTGILETAVRATNaq-------------- 610 
CCI46246      669 LLERIKSLRYLVLMLQPEMCHKLCEYLLERMsrysaaWTDRQA--------LNAHFQESLEDLHndrliseamyrfgsel 740 
ETN60468     1237 LLSHFESLRNYFLLMDGEFSAHICDSLFGRLet---vHSPHEL---LNyqiLHAILDGALYCSnagsdpna--------- 1301
KMZ76085      871 LREHFMALRRYHFIELGDWADLFTMSLWNHK------WRSAEAKNRIPe--LQSLLHVALQRSScesdpfwk-------- 934 
XP_013453289  865 LQEHLLALRRYHFMELADWADLFILSLWRH-------WSVTEATERLPe--IQGLLELSIQKSSceqdtnkn-------- 927 
ONI01657      897 LQEHLLALRRYHFMELADWADLFIMSLWHHK------WCVTEADHRLSe--IQGFLESSVQRSScerdphkd-------- 960 
XP_010652953  914 LQEHFLALRRYHFMELADWADLFIMSLWNHR------WNVTEADQRLSe--IQGLLELSLQRSScerdlkkd-------- 977 
XP_006424018  898 LHEHLLALRRYHFMELADWADLFIMSLWHRK------WCFTEADHKVSe--IQGILELSVQRSSceqdhnkn-------- 961 
EOY33186      909 LQEHLLALRRYHFMELADWADLFIMYLSYHK------WCVTEVDRRVSe--IQGLLELSVQRSScerdhhkd-------- 972 
EEF46514      888 LHEHYRVLRRYYFMEIADWADLFIMSLWHHK------WRTTEAGQRVSe--IQGLLELSVQRSScerdpnkd-------- 951 
6TF9_QP1      611 ------------------fDNPEilKRLDvRLLEvSPGdtGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRM 672 
CCI46246      741 yihlnaqaladatmhsfsmETPSilRPYIkECKMd-IQ--SISILTFSLEIAPPLHLLLGKSLLVKYSQLAVFIMQTKVV 817 
ETN60468     1302 --------------erlsfivRQipDQFD-LYDPn-----AICMLNLSYRVEWPLNLILTPEAIEQYTNVFRYLVKVRRI 1361
KMZ76085      935 ------------rlfvytkEQNS--IPLTtSTi--GAF--D-NMVLLGYKIDWPVNIVVTSKALNIYADIFSFLMQIRLA 995 
XP_013453289  928 ------------rlfvymkGRGK--LPLSaSAi--GLR--SFDFLGLGYHVDWPLCIILTPAALKIYADIFSFLIQVKLA 989 
ONI01657      961 ------------rlfvymkGHDA--MPLSaSVi--GVH--SFNFLGLGYRVDWPISIILSPSALKMYAEIFSFLIQVKLA 1022
XP_010652953  978 ------------klfvymkGHAM--APLStFSt--GVH--SFSFLGLGYRVDWPISIILTPGALKIYADIFSFLIQVKLA 1039
XP_006424018  962 ------------rlfvyikEDGT--SPLStSSt--GVS--SFNFLGLGYRVDWPVSIVLTSNAMEIYADIFRFLIQVKLA 1023
EOY33186      973 ------------rlyvyakGHGM--MPLStSTi--GVR--SFDFLGLGYRVDWPVSIILTHGALKIYADIFNFLIQLKLA 1034
EEF46514      952 ------------rlyvyikGNAV--IPLAtSAi--GVH--SFDFLGLGYHVDWPLSIILTPSALKIYSDIFSFLIQVKLA 1013
6TF9_QP1      673 EYILTdI-Wk----G-HMC---NAKllkg-mpelSGVLHQChilASEMVHFIHQMQYYITFEVLECSWDELWNKV-LKAQ 741 
CCI46246      818 QVALSaIqHrl--qRrTDL---DRQ---------MSVSHVWrlqLASMWHYTKCFQLYLQSQVTSRLWKETKTHMeQAIS 883 
ETN60468     1362 SYALE-NaFe---lLkDARkriGRAllq------spqYARVqliRHKLSQLVNALKTYL-SSMLSASWETFRADLqDATE 1430
KMZ76085      996 LYSLShM-WklikdLrHSK---FSKehvss--vpfneYSTFmkiRLQVNHFVSTLQQYVQSQLSDVSCCRFLHSLqNEVK 1069
XP_013453289  990 LFSLTdV-WcslkdMaHTT---NKGlnaepyqpgaghLNILmkmRHQISHFVSTLQQYVESQLSHVSWCRFLHSLqHKVK 1065
ONI01657     1023 IFSLTdV-WrqlkdLvHSI---SQNndseqnerevshFNALvkmRHQVNHFVSTLQQYVESQLSHVSWCRFLYSLkHKVK 1098
XP_010652953 1040 AFSLTdV-WcslkdLmHLV---SQNrhsslhgqkiqhLHILiktRHQVNHFVSTLQQYVQSHLSHVSWCRFLQSLnHKVK 1115
XP_006424018 1024 VFSLNdV-WrslkdLmHLI---NQSrhstqherevshFNFLiklRHQVNHFVSTLQQYVHSQLSDVSWCKFLHSLkDKVK 1099
EOY33186     1035 IFSLTdV-WcslkdVmHLI---RQKrhsplherevghYNMLmklRHQVNHFVSTLQQYVQSQLSHVSWCKLLHSFkHKVK 1110
EEF46514     1014 IFALSdV-WrslkvLiSRI---LHlqtg-----nytnFISLtydRQQVNHFISTLQQYVQSQLSHISWCRFLHNLkYKVK 1084
6TF9_QP1      742 dLDHIIAAHDVFLDTIISRCLLDSE-SRAL--LNQLRAVFDQIIEFQNAqDALY-RAaleelqqrlqfeerkkeresege 817 
CCI46246      884 -LSAMRQTQMKYVDQLLERFFLLEK---HHmlHQYITASFNHILSFVHDfQSILsLC----------------------- 936 
ETN60468     1431 tMEDLYRKHRTYVKRIIFLCLLNKR-SIEL--YENIEKVFRVVMRFYCHlRSKDwQL----------------------- 1484
KMZ76085     1070 dMLDLESMHMLYLVDSLNICFLSTE-TKEI--SSIIKSILQCALNFHSCiIINNhDG----------------------- 1123
XP_013453289 1066 dMMDLESVHTEYLADSLSICFL-SDeTKAV--GSIIESILQCALDFRSClTIGA-------------------------- 1116
ONI01657     1099 dMMDLQSVHLAYLIDSLDICFL-SDeTRPI--ARIIESILQCALDFRSClTGEM-WD----------------------- 1151
XP_010652953 1116 dMMDLESVHMTYLMDSLHVCFL-SDaTRSV--ATVIESILQCAVDFRFClTGCT-WE----------------------- 1168
XP_006424018 1100 dMMDLESVHMAYLSDALDICFL-SDeTRVV--ASIIEGILQCALDFQSClTRGI-WD----------------------- 1152
EOY33186     1111 dMMDLESVHMAYLIDSLHICFL-SDeTRSI--ASIIENILQCALDFRSClTGAL-WN----------------------- 1163
EEF46514     1085 dMMDLESVHMEYLTDSLHICFL-SDeTRPV--ASIIESILQCALNFRAClTTSI-WD----------------------- 1137
6TF9_QP1      818 wgvtaaeeDVENkr-------iQe-FQESIPkm-rSQLRILTHFYQGIVQQFLVLLt-----TS--TdESLRFLSFRLDF 881 
CCI46246      937 --------TASL----------SpeNEQIAHkilqERMMKTTCQWRHKVHFQIVTLgamfkhSRs---PHIQNLYTSLNY 995 
ETN60468     1485 --------QPPGttqqeryvhpLy-----------GQMLVDELKFDKLVKGTLQIGnk---lYDegYlKEIFEFLHLVNT 1542
KMZ76085     1124 --------KLDSasll---aeiNf-----------PQVLAIKATFERSVNDLYNCYlk---yPKh-CdSGVCSFWNSLDF 1177
XP_013453289 1117 --------CRG-----------D--LGELSTin-iSQVLSIKQKFERSLNEL--HVcyv-kePRh-VnFGLSRFWEYLNY 1170
ONI01657     1152 --------VGTSq---------GnlIARLSGin-iSQVVVIKQMFDKNMKEL--HLcyl-ksPKh-GkFGLSHFWEYLNY 1209
XP_010652953 1169 --------VKQDq---------GdvFSKLSQin-iTQVLAIKRAFDKNLKEL--YLcyl-ksPKh-GeFGLSRFWGYLNY 1226
XP_006424018 1153 --------AELDq---------GdfLGKLSRin-vSQVLAIKQKFDKNLKEL--HLcyl-ksPKh-GeFGLSRFWRYLNY 1210
EOY33186     1164 --------VGLAe---------DdlSDKLSRin-iSQVLTIKQKFDKNLKEL--HLlyi-ksPKh-GeFGLSCFWGYLNY 1221
EEF46514     1138 --------VGLDe---------GglRGKLSRin-iSQVLAIKQKFDKNLKEL--HLcyh-ksPKh-GeFGLYCFWGHLNY 1195
6TF9_QP1      882 NEHY 885 
CCI46246      996 NCFY 999 
ETN60468     1543 NGYY 1546
KMZ76085     1178 NDFY 1181
XP_013453289 1171 NEYY 1174
ONI01657     1210 NKYY 1213
XP_010652953 1227 NEYY 1230
XP_006424018 1211 NEFF 1214
EOY33186     1222 NEFY 1225
EEF46514     1196 NEYY 1199
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