2E9E


Conserved Protein Domain Family
myeloperoxidase_like

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cd09824: myeloperoxidase_like 
Click on image for an interactive view with Cn3D
Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
This well conserved family of animal heme peroxidases contains members with somewhat diverse functions. Myeloperoxidases are lysosomal proteins found in azurophilic granules of neutrophils and the lysosomes of monocytes. They are involved in the formation of microbicidal agents upon activation of activated neutrophils (neutrophils undergoing respiratory bursts as a result of phagocytosis), by catalyzing the conversion of hydrogen peroxide to hypochlorous acid. As a heme protein, myeloperoxidase is responsible for the greenish tint of pus, which is rich in neutrophils. Eosinophil peroxidases are haloperoxidases as well, preferring bromide over chloride. Expressed by eosinophil granulocytes, they are involved in attacking multicellular parasites and play roles in various inflammatory diseases such as asthma. The haloperoxidase lactoperoxidase is secreted from mucosal glands and provides antibacterial activity by oxidizing a variety of substrates such as bromide or chloride in the presence of hydrogen peroxide.
Statistics
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PSSM-Id: 188656
Aligned: 8 rows
Threshold Bit Score: 655.644
Created: 15-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:1MHL: human Myeloperoxidase binds heme, contacts at 4 A
  • Citation:PMID 1320128

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2E9E_A       166 VCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAW---DHGLAYPPFNNVKPSPCEFIN- 241 goat
1310918       38 CPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQ---DNGRALLPFDNLHDDPCLLTN- 113 human
AAH56287     294 TAYMFGEVPNVREQINTLTAYLDAGQVYGSEDGLAKELRDLTNDGGLLRVNNRFK---DNGRELLPFTSVNTNLCATRQk 370 zebrafish
CAF95704     184 SCGAGTLPRRHREQLNGITSFVDASMVYGSSPSLALALRNLSSPLGSMALNSQHSdqgLAYMPFLPRTQSQLDPCGPRNg 263 Tetraodon nigro...
CAG08466     237 NLGYMFGDRNVRQQINTLTAFIDVGQVYGADDVKARFVRDLSSDRGLLKVNPEHT---DNGRELLPFSAIDANMCATRRg 313 spotted green p...
XP_415715    262 SASVCNPRTFTREQINAVTSFIDASMVYGSEESVAKSLRNQTNQLGLMAVNQNFT---DAGLELLPFENKTKSVCVLTN- 337 chicken
NP_001081848 287 SSPVCTPGSPVREQINILTSFIDGSQVYGSDWPLAVKLRNNTNQLGLMAINQRFT---DNGLPFLPFETAEEDFCVLTN- 362 African clawed ...
DAA19200     246 FRLAXKSKNKVRDQISGLTSFVDASMLYGNEVALVMXLRNQTNFLGLLTLSTRFQ---DNGWALLPVENLHNDPASSLN- 321 cattle
Feature 1                          #  #                                                          
2E9E_A       242 -----TTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLARELKrlnphwdgEMLYQEARKILGAFIQIITFRDYLPIV 316 goat
1310918      114 -----RSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKslnprwdgERLYQEARKIVGAMVQIITYRDYLPLV 188 human
AAH56287     371 ilndsTLTEVPCFIAGDARVDENPALNSLHTLFVREHNRLARALHvlnptwssETLYQEARKIVGAFNQILVIKEYLPLI 450 zebrafish
CAF95704     264 sr-rsQGNNTSCFQAGDSRANEHLGMIALHTLFLREHNRLVEELHllnphwgpDTLYQEARKVMGAIHQILTWDHYLPRI 342 Tetraodon nigro...
CAG08466     314 vtnnsSAQEVPCFLAGDDRVNENIALSSLHTLLLREHNRLVRALAslnpdwngERLYQEARKIMGAYFQVLTFRDYLLHI 393 spotted green p...
XP_415715    338 -----KSTNIPCFRAGDKRVTENLGLSALHTVFLREHNRLVTKLGklnphwdgEKLYQESRNIIAAMTQIITYRDYLPLL 412 chicken
NP_001081848 363 -----RSSGIPCFLGGDPRVSEQPGLTAFHTLFVRAHNNIAARLRelnprwsgETLYQEARKIIGGILQKITYKDWLPLL 437 African clawed ...
DAA19200     322 -----HLACIPCFLAGDTQSTETPKLAVMHTRLVTELRCPNPWWTr-------DKLYKEARKIVGAMVQIFTYQDFLHLF 389 cattle
Feature 1                                    #  ##   #  #                         #              
2E9E_A       317 LGSEMqkw-ippYQGYNNSVDPRISNVFTFAFRF-GHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRII-----KD 389 goat
1310918      189 LGPTAmrkylptYRSYNDSVDPRIANVFTNAFRY-GHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVV-----LE 262 human
AAH56287     451 VGTDAynrhlgpYPGYNENVDPTIANVFATAAFRfAHLTIQPFIFRLDENYKNHPQFPSVPLYEAFFSPWRVI-----FE 525 zebrafish
CAF95704     343 LGEDAaarlmppYRGYDPDVDPGIANVFATAAFRfAHVTVHPVVTRLGPGYTTNPQHPPLPLHHSLFASWRIV-----QE 417 Tetraodon nigro...
CAG08466     394 VGPDFiarqlstYPGYDEAVDPSISNVFATAAYRfAHLMVQPTIFRLDENYNEHPRHPSVELHKAFFSPWRIIyegtaRI 473 spotted green p...
XP_415715    413 LAEETskw-iplYSGYHETVDPTVSNVFSLAFRF-GHTSVQPFVSRLDDSFQPMGSLPHVPLHLTFCASWRII-----ME 485 chicken
NP_001081848 438 LGSEMaav-lpaYRSYNESVDPRVSNVFTVVFRM-GHTLIQPFIYRLADGYRPLGPEPQIPLHKTFFNSWRVV-----RE 510 African clawed ...
DAA19200     390 LGENR-------SRKALGPSQAYHASVFTLAFHC-SHTTLQPFMFHLDSQYQASAPNSQVPLSSAFFASWQIA-----YA 456 cattle
Feature 1                                                    #      #                            
2E9E_A       390 GGIDPLVRGLLAKNSKLMNQNKM-VTSELRNKLFQPTHKVHGfDLAAINLQRCRDHG-----MPGYNSWRGFCGLSQPKT 463 goat
1310918      263 GGIDPILRGLMATPAKLNRQNQI-AVDEIRERLFEQVMRIGL-DLPALNMQRSRDHG-----LPGYNAWRRFCGLPQPET 335 human
AAH56287     526 GGIDPVLRGLIGRPAKLNTQDHM-LVNALRERLFAFTSHIAL-DLASLNMQRGRDHA-----IPGYNAWRRFCGLSAPQN 598 zebrafish
CAF95704     418 GGIDPVLRGLLLSPAKLQSPGQM-MVEELTERLFQAQGGMPF-DLAALNLQRGRDHG-----LPGYGSWRRFCGLPVPNT 490 Tetraodon nigro...
CAG08466     474 GGLDPILRGLVGRKAKLNTQQHM-MHDELRDKLFEFSSKMAL-DLASLNLQRGRDHG-----LPGYNEWRKFCGLSQPNN 546 spotted green p...
XP_415715    486 GGIDPLIRGMVVDHAKLMKQNQM-LIEELQNHLFEQTEIMGL-DLAALNLQRGRDHG-----LPGYNAWRRFCGLSQPQT 558 chicken
NP_001081848 511 GGIDPLLRGLMANRAKLNRQNQL-VVDELRERLFVLFKRIGL-DLTAINMQRGREHG-----LPGYNAWRRFCGLSAPSN 583 African clawed ...
DAA19200     457 SGIDPIPGGLMATTPAKLNPQDSrLXDELQDWLFQQVKRTGL-DLAAQHAAAGEDETapalcPTGYNAWRCFCRLFQPQN 535 cattle
Feature 1                                                                                        
2E9E_A       464 LKGLQAVLKNKVLAKKLLDLYKTPDNIDIWIGGNAEPMV---ERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTeKQ 540 goat
1310918      336 VGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLK---RKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSmQQ 412 human
AAH56287     599 EQELAVVMNNTELARKLIELYGTPENIDIWLGGVAEPFA---PGGRVGSLFACLISRQFQKIRDGDRLWFESNGVFTtKQ 675 zebrafish
CAF95704     491 TTDLAEILHNLTLAHTFQLLYGTPHNIDVWVGAIAEPAV---PGGRVGPLLACLLSRQFRALRDGDRFWWEKEGVFSeAQ 567 Tetraodon nigro...
CAG08466     547 LAALAAVMNNTVLAKDLWNLYKTPDNIDVWLGGVAEPFV---PGGRVGPLFACLISTQFQRIRLGDRLWWENPGVFTpAQ 623 spotted green p...
XP_415715    559 VDELSEVLGNTELTKKLMDLYGTPDNIDLWIGAIAEPLI---PRGRVGPLLACIIGTQFRNLRDGDRFWWENPGVFTpQQ 635 chicken
NP_001081848 584 VNELAAVLNNRNLAEKFIKLYGSPENIDIWVGGVAESLV---RNGRIGKLLTCLIGNQFRRARDGDRFYYEQPSVFTnEQ 660 African clawed ...
DAA19200     536 LAQLSRVLKNEGLARKFLDLHGTPDNCHLXIGAITEPLLpgaRVGPLLACLFENRSFEFRRAQDGDRFWGQNXGVFT-ER 614 cattle
Feature 1                                                      
2E9E_A       541 RDSLQKVSFSRLICDNTHITKVPLHAFq---------ANNYPHDFV 577 goat
1310918      413 RQALAQISLPRIICDNTGITTVSKNNIf--------mSNSYPRDFV 450 human
AAH56287     676 KTALASVSMARIICDNTGILKVPRDPF----------RFRSPASFV 711 zebrafish
CAF95704     568 RERLRSVSLSRIICDNSRIARVPADPFshagkvedtlPCSHPLIPR 613 Tetraodon nigroviridis
CAG08466     624 RASLRTTSLARIICDNTNITEVPRQPFq---------YRPRGSGYT 660 spotted green pufferfish
XP_415715    636 LEELTKISMSRVICDNTRIKKLPRDMF----------RASSPENFV 671 chicken
NP_001081848 661 RASIERVTLARVICDNTKITEVPRNVFl---------GNRYPRDFV 697 African clawed frog
DAA19200     615 QHVALSHNSLSRXCDNPGITTDPRGIFraxlcpqgfvPCSYIPGLN 660 cattle

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