1A6D,1A6E,1A6D,1A6E,1Q3S


Conserved Protein Domain Family
cpn60

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cd03343: cpn60 
Click on image for an interactive view with Cn3D
cpn60 chaperonin family. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. Archaeal cpn60 (thermosome), together with TF55 from thermophilic bacteria and the eukaryotic cytosol chaperonin (CTT), belong to the type II group of chaperonins. Cpn60 consists of two stacked octameric rings, which are composed of one or two different subunits. Their common function is to sequester nonnative proteins inside their central cavity and promote folding by using energy derived from ATP hydrolysis.
Statistics
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PSSM-Id: 239459
Aligned: 28 rows
Threshold Bit Score: 696.704
Created: 6-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP/Mg bindingringstacking
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP/Mg binding site [chemical binding site]
Evidence:
  • Structure:1A6E; Thermoplasma acidophilum thermosome with bound ATP
  • Citation:PMID 9546398

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        ####                   #                       
1A6D_A        8 ILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDsiGDIIISNDGATILKEMDveHPTAKMIVEVSKA 87  Thermoplasma aci...
1A6E_A        8 ILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDsiGDIIISNDGATILKEMDveHPTAKMIVEVSKA 87  Thermoplasma aci...
AAL63957     14 VLVLKEGTQRAFGKEALRLNIMIARAIAEVMRTTLGPKGMDKMLIDslGDITITNDGATILDEMDvqHPIAKLLVEISKS 93  Pyrobaculum aero...
ZP_00869448   7 VIILKQNVERTQGYEAQRSNIAAAKALAEAVRSTLGPRGMDKMLIDgtGDVTITNDGITILDEISvqHPGAKMVIEVSRT 86  Methanospirillum...
ZP_00562398   7 PTIIDPRKEQTQGKDALHMNIAAAKAVANIVKTTLGPKGMDKMLVNgvGDIVLTNDGAMILKGMEieHPTAKMIVEVAKT 86  Methanococcoides...
Q9YA66       16 VIILKEGTQRSYGREALRANIMAVRAIAQILKTTYGPKGMDKMLVDslGDITITNNGATILDKMDvaHPAAKMLVQISKG 95  Aeropyrum pernix
AAK41152      5 VLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDsfGDVTITNDGATIVKDMEiqHPAAKLLVEAAKA 84  Sulfolobus solfa...
AAK40620     18 VIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDslGDITITNDGATILDKMDlqHPTGKLLVQIAKG 97  Sulfolobus solfa...
Q9YDK6        8 VLILKEGTQRTYGREALRANILAARVLAEMLKSSLGPRGLDKMLVDafGDITVTNDGATIVKEMEiqHPAAKLLVEVAKA 87  Aeropyrum pernix
AAM05089      8 IFIIDPNKEQTKGRDALSMNIAAAKAVATIVKSTLGPRGMDKMLVNplGDITITNDGATILHDMDieHPTAKMIVEVAQS 87  Methanosarcina a...
Feature 1             #####                                                                  #  
1A6D_A       88 QDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLAVNEARKIIDEIAEKSt--------dDATLRKIALTAL 159 Thermoplasma aci...
1A6E_A       88 QDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLAVNEARKIIDEIAEKSt--------dDATLRKIALTAL 159 Thermoplasma aci...
AAL63957     94 QEEEAGDGTTTAVVLAGALLEEAEKLLEKNIHPTVIVSGFKKALDVAAEHLRKVAIPVnr------tdVDTLRKIAMTSM 167 Pyrobaculum aero...
ZP_00869448  87 QDEEVGDGTTTAVILVGSLMEQAESLLNKKIHPTVICRGYRMGMLKALEILQSMASKTda------ynKDVMKKIVQTAI 160 Methanospirillum...
ZP_00562398  87 QENIAGDGTTSAVVLAGALLEKAEELLDTGIHPTVIIKGFLEASSKAMELLDNYAVQVtk------edRDVLVNIAKTAI 160 Methanococcoides...
Q9YA66       96 QEDEAGDGTKTTVIFAGELLKEAEKLLDINIHPTIIVEGYKEALRKASEVIESIAEPVsy------ddVEKLKLIAKTSL 169 Aeropyrum pernix
AAK41152     85 QDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLGTRIdikdlnssvaRDTLRKIAFTTL 164 Sulfolobus solfa...
AAK40620     98 QDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQEIAQPVti------ndTDVLRKVALTSL 171 Sulfolobus solfa...
Q9YDK6       88 QDAEVGDGTTSVVVLAGALLEKAEKLLDENLHPTIIIEGYTKAMEEALRLVDEAAVPVev------edDSVLRRIAETTL 161 Aeropyrum pernix
AAM05089     88 LENSAGDGTTSAVVFTGALLEKAEALIEKGVHPAVVVKGYRLAAEKAVEMFENLAVSAge------edRDLLVKTASTSI 161 Methanosarcina a...
Feature 1       #                                                                               
1A6D_A      160 Sgknt--glsNDFLADLVVKAVNAVAevrdgk-tivdtaNIKVDKKNGgsvnDTQFIsGIVIDKEKVHSKMPDVVKNAKI 236 Thermoplasma aci...
1A6E_A      160 Sgknt--glsNDFLADLVVKAVNAVAevrdgk-tivdtaNIKVDKKNGgsvnDTQFIsGIVIDKEKVHSKMPDVVKNAKI 236 Thermoplasma aci...
AAL63957    168 Ggkis--etvKEYFADLAVKAVLQVAeerngk-wyvdldNIQIVKKHGgsllDTQLVyGIVVDKEVVHAAMPKRVVNAKI 244 Pyrobaculum aero...
ZP_00869448 161 Tgksi--edvKDKISDISVEAVMKVAtkdgnk-vtvnedDVKIKKHTGgtmdDAELImGCVIDKTRVNQEMPKRVINAKV 237 Methanospirillum...
ZP_00562398 161 Agkss--eafADHISNICVDAALEVEedgk-----vdlnNIMLTQDPGqqidDTEFLeGIVVNKARLHSAMPEKVENPKI 233 Methanococcoides...
Q9YA66      170 Nskav--aeaRDYFAELAVEAVRTVAerrgdr-wyvdlnNIQIVKKHGgslrDTRLVrGIVLDKEVVHPDMPRRVENARI 246 Aeropyrum pernix
AAK41152    165 AskfiaegaeLNKIIDMVIDAIVNVAeplpnggynvsldLIKIDKKKGgsieDSVLVkGLVLDKEVVHPGMPRRVTKAKI 244 Sulfolobus solfa...
AAK40620    172 Gskav--agaREYLADLVVKAVAQVAelrgdk-wyvdldNVQIVKKHGgsvnDTQLVyGIVVDKEVVHPGMPKRIENAKI 248 Sulfolobus solfa...
Q9YDK6      162 AskfvgtgpeRDKIISMVIDAIRTVAekrpdggyevdldYVKIEKKKGgsllDSKLVrGIVLDKEVVHPAMPKRVENAKI 241 Aeropyrum pernix
AAM05089    162 Tgkas--ekyNRLVAELCVSAVLAIHeggk-----adlkHIILTKDVGrrveDTEFVeGVVIDKVALDKNSPLKIVNPNI 234 Methanosarcina a...
Feature 1                                                                                       
1A6D_A      237 ALIDSALEIkkteIEAKVQISdpskIQDFLNQETNTFKQMVEKIKkSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKS 316 Thermoplasma aci...
1A6E_A      237 ALIDSALEIkkteIEAKVQISdpskIQDFLNQETNTFKQMVEKIKkSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKS 316 Thermoplasma aci...
AAL63957    245 ALLDAPLEVekpeIDAEIRINdptqMRAFLEEEERILRGYVDKLKsLGVTVLFTTKGIDDIAQYYLAKAGILAVRRVKRS 324 Pyrobaculum aero...
ZP_00869448 238 AIVQKELEIkkteVKSKIKISsteqVEAFAEQERSALKEMADAVAkTGANVLLCQKGIADAAQFYLAKAGILAIEDVPEA 317 Methanospirillum...
ZP_00562398 234 AILASDISVkktkNKASLQIDsadkMKEFIEQEKADFEAMLDKILdTGATAIIGTKNIDQVAMDYFQKKGVYAIRRVNED 313 Methanococcoides...
Q9YA66      247 ALLDTPLEIekpeIDLEISITspeqIKALYEKQERILQEKIEKIAaTGANVVITQKGIDDVAQHFLAKKGILAVRRVKRS 326 Aeropyrum pernix
AAK41152    245 AVLDAALEVekpeISAKISITspeqIKAFLDEESKYLKDMVDKLAsIGANVVICQKGIDDIAQHFLAKKGILAVRRVKRS 324 Sulfolobus solfa...
AAK40620    249 ALLDASLEVekpeLDAEIRINdptqMHKFLEEEENILKEKVDKIAaTGANVVICQKGIDEVAQHYLAKKGILAVRRAKKS 328 Sulfolobus solfa...
Q9YDK6      242 LVLDAPLEVqkpeLTTKIRVTdiekLESFLEEETRMLRDMVEKIAaTGANVVITQKGIDEVAQHFLAKKGILAVRRVKRS 321 Aeropyrum pernix
AAM05089    235 ALIDTPMETgktaNKAKLQIStvseIENFVKQEDAALFEMADYIIrAGANAVFCSKGMDDKVAAYLQSRGIYATRRVKTD 314 Methanosarcina a...
Feature 1                                                                                #      
1A6D_A      317 DMEKLAKATGAKIVtdlDDLTPSVLGEAETVEERKIgddRMTFVMGCKnpKAVSILIRGGTDHVVSEVERALNDAIRVVA 396 Thermoplasma aci...
1A6E_A      317 DMEKLAKATGAKIVtdlDDLTPSVLGEAETVEERKIgddRMTFVMGCKnpKAVSILIRGGTDHVVSEVERALNDAIRVVA 396 Thermoplasma aci...
AAL63957    325 DIEKLVRATGARLVtsiEDLTEADLGFAGLVEERRVgdeKMVFVEQCKnpKAVSILVRGGFERLVDEAERNLDDALSVVS 404 Pyrobaculum aero...
ZP_00869448 318 DLKFAARSLGATIVtkaEDLKKSDLGVAEKAEQLDDa--DMVVITGAKnpKTVTILLRGSTYYLVDELERAVVDATRVVM 395 Methanospirillum...
ZP_00562398 314 DIKAISRATGAHIVkniMDISEKDLGTADLVEQIGAfdlGKTYIRGCKntNTITILLRGSTEHITDNLERTMDDALNVIK 393 Methanococcoides...
Q9YA66      327 DIEKIARATGARIVtdiEDLRPEDLGYAELVEERKVgedKMVFIEGAKnpKSVTILLRGGFERLVDEAERSLHDALSVVA 406 Aeropyrum pernix
AAK41152    325 DIEKLEKALGARIIssiKDATPEDLGYAELVEERRVgndKMVFIEGAKnlKAVNILLRGSNDMALDEAERSINDALHALR 404 Sulfolobus solfa...
AAK40620    329 DLEKLARATGGRVIsniDELTSQDLGYAALVEERKVgedKMVFVEGAKnpKSVSILIRGGLERVVDETERALRDALGTVA 408 Sulfolobus solfa...
Q9YDK6      322 DIEKVAKATGAKIVtslRDLKPEYLGYAELVEERKVgedKMVFIEGAKnpKSVTILLRGANDMLLDEAERNIKDALHGLR 401 Aeropyrum pernix
AAM05089    315 DMQHLADATGGRPVrniKELTEKELGHAGLLEQDRDedqGKTYLRDCKgaKSVSIVLRGGTEHVVDNLERAIDDALRVVK 394 Methanosarcina a...
Feature 1                  ##                                                                   
1A6D_A      397 ITKEDgKFLWGGGAVEAELAMRLAKYansvgGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADdekg-risVG 475 Thermoplasma aci...
1A6E_A      397 ITKEDgKFLWGGGAVEAELAMRLAKYansvgGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADdekg-risVG 475 Thermoplasma aci...
AAL63957    405 DVVEDpYILPAGGAAEIEAAKAVRAFapkvgGREQYAVEAFARALEVIPKALAENAGLDPIDILTELTHKheqtdgwkYG 484 Pyrobaculum aero...
ZP_00869448 396 DAMEDgLFVPGGGAVESELTVRLRDYavnvgGREQIAIEAYADAFAAIPITLAENSGYNPIDKLVELKKAhaeg-kknFG 474 Methanospirillum...
ZP_00562398 394 NTIEDgMIVAGGGASEIEIAQGLKSYatsvgGREQLAVSAFAEALESIPREIAINAGMDGIDTILALRAKhte--iknAG 471 Methanococcoides...
Q9YA66      407 DAIMDgKIVAGGGAVEAEVAKVLYEYasklpGKTQLAVEAFARAVEALPQALAHNAGHDPIEVLVKLRSAhekpenkwYG 486 Aeropyrum pernix
AAK41152    405 NILLEpVILPGGGAIELELAMKLREYarsvgGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARhakg-lsnTG 483 Sulfolobus solfa...
AAK40620    409 DVIRDgRAVAGGGAVEIEIAKRLRKYapqvgGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLhenetnkwYG 488 Sulfolobus solfa...
Q9YDK6      402 NILREpKIVGGGGAVEVELALKLKEFartvgGKQQLAIEAYAEALETIPTVLAESAGMDALEALLKLRSLhsqg-ykfAG 480 Aeropyrum pernix
AAM05089    395 CVVEDgKVVAGGGASEMEVALSIRSYassigGREQTAITAFAEALEEIPRTIARNAGLDAIDSILNLRAKhae--nknAG 472 Methanosarcina a...
Feature 1                     # # #                             
1A6D_A      476 VDLdnn-gvGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASK 522 Thermoplasma acidophilum
1A6E_A      476 VDLdnn-gvGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASK 522 Thermoplasma acidophilum
AAL63957    485 LDVyqg-kvVDMVSLGLVEPLTVKINALKVAVEAASMILRIDEIIAAS 531 Pyrobaculum aerophilum str. IM2
ZP_00869448 475 LNVytg-klVDMQKEGVIEPIRCKRQAIQSSEEAVEMLLRVDDMMVSQ 521 Methanospirillum hungatei JF-1
ZP_00562398 472 LDVyst-eiVDTFEKGIVDSLRVKKQAIKSASEVANMVLRVDDMLKAR 518 Methanococcoides burtonii DSM 6242
Q9YA66      487 VDLdtg-eiVDMWSRGVLEPMRVKLNALKAATEVASLILRIDDVIAAR 533 Aeropyrum pernix
AAK41152    484 VDViggkivDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAA 531 Sulfolobus solfataricus P2
AAK40620    489 LNLftg-npEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAG 535 Sulfolobus solfataricus P2
Q9YDK6      481 VNVlegkieEDMTKINVYEPVLVKKQVIKSASEAAISILKIDDVIAAA 528 Aeropyrum pernix
AAM05089    473 LNIqtg-aaEDMLEKGVVDPLRVKVNTIKAGSEAAAMVLRVDSMLRAQ 519 Methanosarcina acetivorans C2A

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