1QHW,1WAR,1UTE,2BQ8,1QFC,3TGH


Conserved Protein Domain Family
MPP_ACP5

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cd07378: MPP_ACP5 
Click on image for an interactive view with Cn3D
Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
Acid phosphatase 5 (ACP5) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Statistics
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PSSM-Id: 277324
Aligned: 29 rows
Threshold Bit Score: 245.312
Created: 9-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1QHW: Rat purple acid phosphatase binds a Zn2+, 2 Fe3+, and a S04-
  • Structure:1WAR: Human purple acid phosphatase binds 2 Zn2+ and a SO4-

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                                        
1QHW_A        28 LRFVAVGDWGgvpna-------------------------------------pfhtAREMANAKEIARTvqi-mgADFIM 69  Norway rat
ABR17561      45 LKFLVVGDWGrk------------------------------------------glFNQSQVAAQMGKIaqq-lhIDFII 81  Sitka spruce
YP_001616148  97 VRILALGDTGeg-------------------------------------------nLAQNQVADRMSEKcievggCHAVM 133 Sorangium cellu...
AAM61192      46 VSFIVIGDWGrr------------------------------------------gsFNQSLVAYQMGKIgek-idLDFVV 82  thale cress
XP_625471     31 LTVFSIGDWGek-------------------------------------------tECLVNVTTKMGSLesa-mnPKFII 66  Cryptosporidium...
EED13558      38 LTVGILGDFGwsgwspantyfcnevapvltaknitiprelqndcdagdraaaqnasAAQVSTASYIKNIctm-knCSAFI 116 Talaromyces sti...
AAT07037      52 LKFVGLGNWGsg-------------------------------------------sYGQKTVADTLKKVaan-ehISFIA 87  Toxoplasma gondii
CAR62531      27 LRFASLGDWGkd-------------------------------------------tKGQILNAKYFKQFikn-erVTFIV 62  malaria parasit...
Q9SCX8        46 VSFIVIGDWGrr------------------------------------------gsFNQSLVAYQMGKIgek-idLDFVV 82  thale cress
Q8S341        41 LSFLVIGDWGrk------------------------------------------ggFNQSLVAHQMGVVgek-ldIDFVI 77  thale cress
Feature 1           #  #                                      #                                  
1QHW_A        70 SLGDNFYFTGvhdan--dkrfqETFEDVFsdra-lrniPWYVLAGNHDHl-----GNVSAQIAYSki------------- 128 Norway rat
ABR17561      82 STGDNFYEDGlngtd--dpsfeQSFSAIYsass--lqtPWHLVLGNHDYr-----GDTLSQLDSAlkr------------ 140 Sitka spruce
YP_001616148 134 MNGDNFYDHGvvdti--dtqwgPKFEQPYdrpg-lsglPFYAVLGNHDYgps-ssGVRQAQIDYSqlpvgdg-------- 201 Sorangium cellu...
AAM61192      83 STGDNFYDNGlfseh--dpnfeQSFSNIYtaps--lrkQWYSVLGNHDYr-----GDAEAQLSSVlre------------ 141 thale cress
XP_625471     67 SVGDNFYQRGvksve--daawtEILEEPFgkls--khlKVHSCLGDHDWr-----GSTTAQIDRTnya------------ 125 Cryptosporidium...
EED13558     117 SVGDNFYDSGvgftttgvnrfqETWVDMYsqgi-yenaTWYQCLGNHDIvygqagVDFETKIAPLyddr----------- 184 Talaromyces sti...
AAT07037      88 SPGSNFLGGVsslnd---trwqSEFENVYsdangalkmPFFTVLGVDDWs-----RNYTSEALRTeltyavtseqikdgk 159 Toxoplasma gondii
CAR62531      63 SPGSNFIDGVkgldd---pawkNLYEDVYseekgdmymPFFTVLGTRDWt-----GNYNAQLLKGqgiyiekngets--- 131 malaria parasit...
Q9SCX8        83 STGDNFYDNGlfseh--dpnfeQSFSNIYtaps--lqkQWYSVLGNHDYr-----GDAEAQLSSVlre------------ 141 thale cress
Q8S341        78 SVGDNFYDDGlkgvn--dpsfeASFSHIYthps--lqkQWYSVLGNHDYr-----GNVEAQLSKVltq------------ 136 thale cress
Feature 1                                                                                        
1QHW_A       129 ----------------skRWNFPSPYYRLRFkvpr--------------------------------------------- 147 Norway rat
ABR17561     141 ---------------rdsRWNCYRTSTLRQNlplsck------------------------------------------- 162 Sitka spruce
YP_001616148 202 -----------pgmrltdKWHMPASYYDVRIg------------------------------------------------ 222 Sorangium cellu...
AAM61192     142 ---------------idsRWICLRSFVVDAEl------------------------------------------------ 158 thale cress
XP_625471    126 ---------------nntRWYLPGYWWYEKVtftsevslpslfeksglgeisannsfhfnssktenstsceidcldeivd 190 Cryptosporidium...
EED13558     185 --------------wyfgTEGLPYYTYDIVGqd----------------------------------------------- 203 Talaromyces sti...
AAT07037     160 lapadateaaaaenhgypKWTLPNWWYHYLMhfpantggaf--------------------------------------- 200 Toxoplasma gondii
CAR62531     132 -------iekdadatnypKWIMPNYWYHYFThftvssgpsi--------------------------------------- 165 malaria parasit...
Q9SCX8       142 ---------------idsRWICLRSFVVDAEl------------------------------------------------ 158 thale cress
Q8S341       137 ---------------kdwRWFCRRSFVLSSGm------------------------------------------------ 153 thale cress
Feature 1                                                                                        
1QHW_A       148 ------------------------------snitVAIFMLDTvmlcgnsddfvsq----qpemprdlgvarTQLSWLKKQ 193 Norway rat
ABR17561     163 ----------------------------garcsfLEFFFIDTtpfvdlywtyakhq-ydwrgilprerylkKQLKALNNA 213 Sitka spruce
YP_001616148 223 ---------------------------------dVHLFGIDTvdf-----------------------tsdDQARYMSAR 246 Sorangium cellu...
AAM61192     159 ----------------------------------VEMFFVDTtpfvkeyyteadghsydwravpsrnsyvkALLRDLEVS 204 thale cress
XP_625471    191 nlntmvnrnnswnedlsyktsiseyfsekqvnstAVFIYIDSwtltqdpfk------------ktsisykySQLEFIEQT 258 Cryptosporidium...
EED13558     204 --------------------------------wtATFVVVDSdcfiekyqksssvy--qngyttscykekqTQVDFVTQA 249 Talaromyces sti...
AAT07037     201 -------------------------insghkdmsVGMIFIDTwvlsssf---------------pfsnvtsRAWADLEKT 240 Toxoplasma gondii
CAR62531     166 -------------------------vktghkdlaAAFIFIDTwvlssnf---------------pykkiheKAWNDLKSR 205 malaria parasit...
Q9SCX8       159 ----------------------------------VEMFFVDTtpfvkeyyteadghsydwravpsrnsyvkALLRDLEVS 204 thale cress
Q8S341       154 ----------------------------------VDFFFADTnpfvekyftepedhtydwrnvlprnkyisNLLHDLDLE 199 thale cress
Feature 1                        #        #                             # #                      
1QHW_A       194 LAAAKe---dYVLVAGHYPIWSIAEHgpt-rcLVKNLRPLLAAYg---VTAYLCGHDHNLQYLQde-----ngVGYVLSG 261 Norway rat
ABR17561     214 LKVSKa---tWKIVVGHHPIRSIGTHddt-aeLKQQLLPILEANk---VDLYVNGHAHCLQDFKskt----ssMHFLTSG 282 Sitka spruce
YP_001616148 247 VAASDa---tWKIVFGHHPRYTSGAHasdnpsLGMSGMFAMQQAiycgTDMYMAGHDHNLEFIDkgrdegcpnTYFAISG 323 Sorangium cellu...
AAM61192     205 LKSSKa---rWKIVVGHHAMRSIGHHgdt-keLNEELLPILKENs---VDLYMNGHDHCLQHMSded----spIQFLTSG 273 thale cress
XP_625471    259 LKAAVfenvdWIILVTHYSIYSSGLHgph-trLASILLPLIKKYr---VDFIISGHDHHSEILVped----fnSYFQIVG 330 Cryptosporidium...
EED13558     250 FAKSTa---dWKFLQIHHGFLSSSTNy----tELWPLVSVAEKH----NGIVLNGHDHCAAHYVgn------kTNFVLSG 312 Talaromyces sti...
AAT07037     241 LELAPki-ldYIIVVADRAVYSSGASkgd-smLQYYLQPLLKKAn---VDAYISGYDFSLEVISdd------nISHVSCG 309 Toxoplasma gondii
CAR62531     206 LSVAKki-adFLIVVGDQPIYSSGYSrgs-syLAYYLLPLLKDAe---VDLYISGHDNNMEVIEdn------dMAHITCG 274 malaria parasit...
Q9SCX8       205 LKSSKa---rWKIVVGHHAMRSIGHHgdt-keLNEELLPILKENg---VDLYMNGHDHCLQHMSded----spIQFLTSG 273 thale cress
Q8S341       200 IKKSRa---tWKFVVGHHGIKTAGNHgvt-qeLVDQLLPILEENk---VDLYINGHDHCLQHIGsh-----gkTQFLTSG 267 thale cress
Feature 1                                                             
1QHW_A       262 AGNFMDPsvrhqrkvpngy-lrfhygsedslGGFTYVEIGskeMSITYVEASG 313 Norway rat
ABR17561     283 GGSKAWGgvssnankd-------glkffypgQGFMSMQITtmfVNAVFYDIDG 328 Sitka spruce
YP_001616148 324 AGSKTRPvassipter------gqlfftdktEGFAYLRFEgtnLLFEFIDKQG 370 Sorangium cellulosum 'So ce 56'
AAM61192     274 AGSKAWRgdinpvtinp-----kllkfyydgQGFMSARFThsdAEIVFYDVFG 321 thale cress
XP_625471    331 ASSKPRTsfgatden---------sifksntCSFASFTFSkdiAVSRIFSINS 374 Cryptosporidium parvum Iowa II
EED13558     313 AAGYPEAgdcnngvslgsfvkflgadaagagNGFVTLDISskeLVFEYYIRDM 365 Talaromyces stipitatus ATCC 10500
AAT07037     310 AGSKAAGspivkhsg---------slyyageTGFCLFELTaegLVTRLVSGTT 353 Toxoplasma gondii
CAR62531     275 SGSMSQGksgmknsk---------slffssdIGFCVHELSnngIVTKFVSSKK 318 malaria parasite P. falciparum
Q9SCX8       274 AGSKAWRgdinpvtinp-----kllkfyydgQGFMSARFThsdAEIVFYDVFG 321 thale cress
Q8S341       268 GGSKAWRghvqpwdpk-------elklyydgQGFMSLHIThskAKFIYYDVSG 313 thale cress

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