2ALE,2OZB,5EWR,2AIF,4NUT,2JNB


Conserved Protein Domain Family
SNU13

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cd21104: SNU13 
U4/U6.U5 small nuclear ribonucleoprotein SNU13
U4/U6.U5 small nuclear ribonucleoprotein SNU13, also known as NHP2-like protein 1 or U4/U6.U5 tri-snRNP 15.5 kDa protein, is a component of the spliceosome B complex, involved in pre-mRNA splicing. It binds to the 5'-stem-loop of U4 snRNA.
Statistics
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PSSM-Id: 411046
Aligned: 62 rows
Threshold Bit Score: 224.129
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingheterodimer
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2OZB; Homo sapiens SNU13-PRP31 complex with bound U4snRNA, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     ######  #   #           ##   #                    #
2ALE_A         5 NPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSR 84  baker's yeast
2OZB_A         9 NPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSK 88  human
5EWR_A        25 DPRAYPFAPADLVVEILDLVQQASHYKQIKKGLNEVLKSMNRGLAEFVVLAADTQPLEILLSAPLVAEDKAVPYVFVPSK 104 Cyanidioschyzon...
2AIF_A        14 NPKAFPLASPDLNNKIINLVQQACNYKQLRKGANEATKALNRGIAEIVLLAADAEPLEILLHLPLVCEDKNTPYVFVRSK 93  Cryptosporidium...
XP_002673437   5 NPKAYPLADDDLTVSILDLIQSSHNYNQVKRGANEVTKAVNRGIASFVILAADAEPIEILMHLPVLCEDKNIPYCFVKSK 84  Naegleria grube...
XP_002783905   7 NPKAYPLASADLTATIMDLVQQSCNYKQLRKGANEATKTLNRGTAEVIVLAADTEPLEIILHLPLVCEDKNVPYVFVKSK 86  Perkinsus marin...
XP_792122      6 NSKAYPLADGDLTKKLLNLVQQAVNYKQLKKGANEATKTLNRGISEFIILAADAEPLEILLHLPLLCEDKNVPYVFVRSK 85  Strongylocentro...
ELT99904       7 NPKAYPLADPQLTVKILDLVQQAANYKQLRKGANEATKTLNRGISEFIVMAADAEPLEILLHLPLLCEDKNVPYVFVRSK 86  Capitella teleta
XP_002741224   8 NPKAYPLADPQLTKEILDLVQQASNYKQLRKGANEATKTLNRGIAEFIVMAADTEPLEILLHLPLLCEDKNVPYVFVRSK 87  Saccoglossus ko...
XP_002607098  10 NPKAYPLADAQLTTQILDLVQQAANYKQLRKGANEATKTLNRGITEFIVMAADTEPLEIILHLPLLCEDKNVPYVFVRSK 89  Branchiostoma f...
Feature 1                ######                             
2ALE_A        85 VALGRACGVSRPVIAASITTNDa-SAIKTQIYAVKDKIETLLI 126 baker's yeast
2OZB_A        89 QALGRACGVSRPVIACSVTIKEg-SQLKQQIQSIQQSIERLLV 130 human
5EWR_A       105 AALGRACGVSRPVIACAVLRADm-SQLRNQITALRTKIEQLLL 146 Cyanidioschyzon merolae
2AIF_A        94 VALGRACGVSRPVIAAAITSKDg-SSLSSQITELKDQIEQILV 135 Cryptosporidium parvum
XP_002673437  85 TALGRACGISREVISATVINNEnnAALKKQVNSLKDAIERIIV 127 Naegleria gruberi strain NEG-M
XP_002783905  87 TALGRACGVSRPVVACSITSKEg-SQLMTQIQDLKDSIEQILI 128 Perkinsus marinus ATCC 50983
XP_792122     86 EALGRACGVSRPVISCSVTTNEg-SQLKPQILIIQQAIEKLLI 127 Strongylocentrotus purpuratus
ELT99904      87 QALGRACGVSRPVISCSVTVNEg-SYLKPQITGIQQAIEKLLI 128 Capitella teleta
XP_002741224  88 QALGRACGVSRPVIACSVTINEg-SQLKPQIQAIQQNIERLLI 129 Saccoglossus kowalevskii
XP_002607098  90 QALGRACGVSRPVIAASVTINEg-SQLKSQITTVQQAIERLLI 131 Branchiostoma floridae

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