2BIJ,2CJZ


Conserved Protein Domain Family
PTPc-N5
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cd14613: PTPc-N5 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 5
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5), also called striatum-enriched protein-tyrosine phosphatase (STEP) or neural-specific PTP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN5/STEP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. It is a CNS-enriched protein that regulates key signaling proteins required for synaptic strengthening, as well as NMDA and AMPA receptor trafficking. PTPN5 is implicated in multiple neurologic and neuropsychiatric disorders, such as Alzheimer's disease, Parkinson's disease, schizophrenia, and fragile X syndrome.
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Statistics
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PSSM-Id: 350461
Aligned: 7 rows
Threshold Bit Score: 515.567
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 15 residue positions
Conserved feature residue pattern:x x x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Structure:2CJZ: Human PTPN5/STEP binds phosphotyrosine; contacts at 4A
    - View structure with Cn3D
  • Comment:also based on the structure of human PTPN7/HePTP with bound monophosphorylated peptide substrate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #####                                              
2BIJ_A        40 FLLQAEFFEIPMNFVDPKEYDipglvRKNRYKTILPNpHSRVCLTspdp-ddpLSSYINANYIRGYGgeeKVYIATQGPI 118 human
2CJZ_A        40 FLLQAEFFEIPMNFVDPKEYDipglvRKNRYKTILPNpHSRVCLTspdp-ddpLSSYINANYIRGYGgeeKVYIATQGPI 118 human
XP_005237508 258 FILQAEFFEIPMNFVDPKEYDipglvRKNRYKTILPNpHSRVCLTsadq-ddpLSSYINANYIRGYGgeeKVYIATQGPI 336 peregrine falcon
XP_687962    262 GVLQAEFYETPMNFVDPKEYSipgvvRKNRYKTILPNtHSRVCLKakee-gdfLSTYINANYLKGYGgkeKAYIATQGPT 340 zebrafish
XP_005990583 294 FSLQTEFFEIPMNFVDPKEYDipglvRKNRYKTILPNpHSRVCLTstdq-edpLSSYVNANYLRGYGaeeKAYIATQGPT 372 coelacanth
XP_018410654 216 FTLQKEFFEIPMNFVDPKEYEilglvRKNRYKTILPNpQTRVCLIspdqeddpLSSYVNANYIRGYGeeeRVYIATQGPT 295 Nanorana parkeri
XP_007882862 222 AALHAEFLEIPMNFTDPKEFDipgfgLKNRYKTILPNpHSRVQLItes--edpLSSYINANYIRGYGgeeRVYIATQGPT 299 elephant shark

Feature 1                                                                                        
2BIJ_A       119 vstvaDFWRMVWQEHtPIIVMITNIeemNEKCTEYWPeEQVAYdgVEITVQKVIHTedYRLRLISLKsgteERGLKHYWF 198 human
2CJZ_A       119 vstvaDFWRMVWQEHtPIIVMITNIeemNEKCTEYWPeEQVAYdgVEITVQKVIHTedYRLRLISLKsgteERGLKHYWF 198 human
XP_005237508 337 vntvsDFWRMVWQERsPIIVMITNIeemNEKCTEYWPeEQVTYegIEITVNRVIQAddYRLRLITLKkgeeVRNLKHYWY 416 peregrine falcon
XP_687962    341 vntvgDFWRMVWQERcPIIVMITNIeekNEKCTEYWPeDSVTCegIEITVKQVIQAddYSLRIFTVKsegeERSLRQYWY 420 zebrafish
XP_005990583 373 vntvsDFWRMVWQQRsPIVVMITNIeemNEKCTEYWPeERVIYegIEIIVDQVIHAddYRLRHITLKsgeeERKLKHYWY 452 coelacanth
XP_018410654 296 vntvgDFWKMVWQEHsPIIVMITNIeevNEKCTEYWPeKQAVYegIEVTIKDIIPDddYVLRIMTLKsdgeERILKHFWY 375 Nanorana parkeri
XP_007882862 300 vstvcDFWRLVWQERcSIVVMITNLeekNEKCTVYWPaRQGLYggVEVTVTQELCEedYSLRLLTLRaggeERCMRHYWY 379 elephant shark

Feature 1            ##                                     #######                              
2BIJ_A       199 TSWPDQKTPdrAPPLLHLVREVEEAaqqeg----phcaPIIVHCSAGIGRTGCFIATSICCQQLrqEGVVDILKTTCQLR 274 human
2CJZ_A       199 TSWPDQKTPdrAPPLLHLVREVEEAaqqeg----phcaPIIVHSSAGIGRTGCFIATSICCQQLrqEGVVDILKTTCQLR 274 human
XP_005237508 417 TSWPDQKTPdqAPPLLQLVLEVEEAmqsae----eknaPVIVHCSAGIGRTGCFIATSVCCKQLksEGIVDILRTACQLR 492 peregrine falcon
XP_687962    421 TSWPDQKTPdkAPPLLELVQEVEEArkqap----pnsgPVIVHCSAGIGRTGCFIATSILCQQLsnEGVVDILKTTSQLR 496 zebrafish
XP_005990583 453 TSWPDQKTPdnAPPLLQLVQEVEEArqcae----enagPMIIHCSAGIGRTGCFIATSIGCKQLknEGVVDILRTTCQLR 528 coelacanth
XP_018410654 376 TSWPDQKTPdqAPALLKLVKDVEEArqkae----lddgPVIVHCSAGIGRTGCFIATTLLCKQMknGGKVNILRTTCQLR 451 Nanorana parkeri
XP_007882862 380 TSWPDQKTPdnARPLLQLVQEVEAArqqargaatashsPLIVHCSAGIGRTGCFIATSICYMELrnAAVVDILRTACQLR 459 elephant shark

Feature 1               #               
2BIJ_A       275 QDRGGMIQTCEQYQFVHHVMSLY 297 human
2CJZ_A       275 QDRGGMIQTCEQYQFVHHVMSLY 297 human
XP_005237508 493 LDRGGMIQTCEQYQFVHHVMSLY 515 peregrine falcon
XP_687962    497 LDRGGMIQTAEQYQFVHHVLSLY 519 zebrafish
XP_005990583 529 LDRGGMIQTCEQYQFVHHVLSLY 551 coelacanth
XP_018410654 452 LDRGGMIQTSEQYQFVHHVLSLF 474 Nanorana parkeri
XP_007882862 460 LDRGGMIQTVEQYQFVHHALSLC 482 elephant shark

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