Conserved Protein Domain Family
RFX_DNA_binding
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pfam02257: RFX_DNA_binding (this model, PSSM-Id:396712 is obsolete and has been replaced by 460512)
RFX DNA-binding domain
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).
Links
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Statistics
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PSSM-Id: 396712
Aligned: 68 rows
Threshold Bit Score: 90.6761
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_026690016            74 ITTEWLTKNFEENSL-TSVPRSIMFDEYQKFCRDSNT-KPFNQAVFGKIVRACFPNLTTRRLG---VRGQSR-YHYAGLS 147  vase...
XP_004995448           294 dTVTWLRANFELKTG-FTVERRLVYKAYCRHMQSMMQ-EPCNAAGFGKVIRGVFPGVTSRRLG---SRGHSK-YHYEGLR 367  Salp...
XP_002111154           456 FAHAWLNATYDCCTG-GYVPRSGMYSDYLATCNRLSItGIVNSTTFSRLIHEVFPSAEIKRV----TYGNTNqYFYTGVR 530  Tric...
XP_002416101           388 FAGTWVRAMYEPAPPgCSVARNDIYAEYVTFCSKAGRkSVISASVFANCVKAVYSQTGIRRVDn--ANGMMS-FHHDGLR 464  blac...
EEN42662               129 FTCSWLNSLYEVDSE-GSVARIDLYADYLSSCSKLARvGILTSTHFYRCVKTLFPNTGSKRVD---TNGQVV-YHISGIK 203  Flor...
XP_008257582           523 FACQWLNAHFEINLD-CSVSRAEMYSEYLSTCSKLARgGILTSTGFYKCLRTVFPNHTVRRVEdssSSGQAH-IHVVGVR 600  rabbit
XP_015208422           524 FTTQWLNAHFEVHSD-SSVSRSEMYSEYLATCSKMARgGILTSTGFYKCLRSIFPNHTVKRMEdpkTNGQAH-IHVVGIR 601  spot...
EPS95356               217 FVQAWLTANYAPYPD-GNVPRQGLYFSYRRVCDQYGI-PHINTATLGKAIRLCFPTIKTRRLG---VRGNSK-YHYCGIR 290  Fomi...
WGS:AAWC:PGTG_11391.3  427 FVQAWLNSSYISYTD-GNVSRQGLYGSYLRICQQYDI-KPINSASFGKSVRQSFPNIKTRRLG---VRGNSK-YHYCGIR 500  Pucc...
GAA96359               354 FVQAWLQQSYTTCTE-GNVSRQGLYGSYLDTCESYGI-KAVNSASFGKAVRHVFVNIRTRRLG---VRGNSK-YHYVGMR 427  Mixi...

XP_026690016           148 V 148  vase tunicate
XP_004995448           368 I 368  Salpingoeca rosetta
XP_002111154           531 K 531  Trichoplax adhaerens
XP_002416101           465 K 465  black-legged tick
EEN42662               204 K 204  Florida lancelet
XP_008257582           601 R 601  rabbit
XP_015208422           602 R 602  spotted gar
EPS95356               291 P 291  Fomitopsis pinicola FP-58527 SS1
WGS:AAWC:PGTG_11391.3  501 P 501  Puccinia graminis f. sp. tritici CRL 75-36-700-3
GAA96359               428 A 428  Mixia osmundae IAM 14324
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