Conserved Protein Domain Family
CENP-Q
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pfam13094: CENP-Q (this model, PSSM-Id:404080 is obsolete and has been replaced by 432970)
CENP-Q, a CENPA-CAD centromere complex subunit
CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 404080
Aligned: 80 rows
Threshold Bit Score: 55.7537
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ERS99257      62 VRSKLVKgIPFPPgtvhivsrrgrpstkplpdddrnglAADFNFERAVEEAHALEQQLSPLQHAVALLKRERK-HEEEAL 140 Sporothrix sche...
EFB15241      65 LLQLCET-LKVPP-------------------------KKLKDLTNVSSLLKMEKAQHRDNEEGLALLQEEID-KIVETL 117 giant panda
EGW03091     118 LLQQCGT-VKVPP-------------------------RQLNYLTNVSNLLKMETAQQRANKAELALLQEEID-KIVETT 170 Chinese hamster
Q66H02       119 FLQQCAT-LKVPP-------------------------GKLNYLRDMSKLLKVEREQERANEESLASLQEEID-KIVETT 171 Norway rat
2_pfamImport   2 LPQLCET-LKVPP-------------------------EKLKDLTRVSSLLNVE-LQERTNKERLALLLKEIE-KVVETA 53 
XP_005318648 117 LLQLCET-MKVPP-------------------------RKLKYLTNVSNLLKMEKAQETANEEGLALLQEEID-KMVETT 169 thirteen-lined ...
XP_003467922 113 LLQLCET-LKAPR-------------------------QKLTYLTNMSSLLKIERAQDRANEEGMALLQEEID-KIVQTT 165 domestic guinea...
EHB10238      31 LLQLCEI-MEAPP-------------------------RNLKYLTNVTRLLKAERAQDRDN-EGLALLQEEIDnKIVQTT 83  naked mole-rat
XP_003311370 117 FLQVCET-LKVPP-------------------------KKMEDLTNVSSLLNMERARDKANEEGLALLQEEID-KMVETT 169 chimpanzee
XP_007238307 102 FLAKCAQ-LPVPS-------------------------RKSGNMMQVSRQFHTESQKVKHGKKKIEAYEESSR-EVLNKL 154 Mexican tetra

ERS99257     141 AADYAALRQLETNAQADLRT-WRD--RTRRAHVLAPvdvgdnrslkggnddslqfvelakrapalggndhgkdenennen 217 Sporothrix sche...
EFB15241     118 ESMTGNIQSLRNKVQVLTSEvEAEeeKVKQ---MFQidssgvlc------------------------------------ 158 giant panda
EGW03091     171 ESMTETIQSLKHQIEILTNEvEEEeqQVKE---KFHvdsnrvls------------------------------------ 211 Chinese hamster
Q66H02       172 ESMTENIESLKTKIEILTNEvEKEeeEMKE---VFHidsnkvla------------------------------------ 212 Norway rat
2_pfamImport  54 ELMTENIQSLKNKIEILAREvEEEekTLKQ---VLQmdsrsvfs------------------------------------ 94 
XP_005318648 170 ESMTENIHRLKNKIQIVAHE-VEE--EEEKVKQMLQmdssgvls------------------------------------ 210 thirteen-lined ...
XP_003467922 166 ESVTGNIKSLKNKIEILTHE-IEE--EEEKAKEVLQldrhnvls------------------------------------ 206 domestic guinea...
EHB10238      84 ESVTGNIQSLKNKTDILTHEiEEEeeKAKE---TLQldrrntls------------------------------------ 124 naked mole-rat
XP_003311370 170 ELMTGNIQSLKNKIKILASE-VEE--EEERVKQMHQinssgvls------------------------------------ 210 chimpanzee
XP_007238307 155 EQLQGQRDSLEDKCRIMRDK-LED--EEENAQELTQmseqavln------------------------------------ 195 Mexican tetra

ERS99257     218 gqsrdksqngglfEHL----DKDLSTVAA---QLSNHMDSLkSNLQQIAGVLPAMTQTKAALQ 273 Sporothrix schenckii ATCC 58251
EFB15241     159 ------lpelsqkSLKaptlQKEILTLIPnhnALLKDLHVL-HNSSQMKNMLTFIEEAYKRLD 214 giant panda
EGW03091     212 ------lpelpqkSLKapilQKEILAVIPnqkALLKDLDVL-HNSSPVKNMSAFIQEAYKKLD 267 Chinese hamster
Q66H02       213 ------lpelsqkSLKapilQKEILTLIPnqnALLKDLDVL-QNSAPGKNMAAFIQEAYMKLN 268 Norway rat
2_pfamImport  95 ------ltelsqkSLKaptlQKEILTLIPnqnALLQDLDAL-HNSSQIKNMVTFIEEAFKKLD 150
XP_005318648 211 ------lpelsqnSLKaptlHKEILMLIPnqnALLKDLDVL-HSSSQMKNLSMFIEEAYKKLD 266 thirteen-lined ground squirrel
XP_003467922 207 ------lpelsqnSLKtptlQKEMLMLIPnqkVLLKDLDIL-HNSSQMKNMAMFIEEAYKKLN 262 domestic guinea pig
EHB10238     125 ------lpelsrhSLEaptlQKEGLMLTLnqnVLLKDLDVL-HNSSQMKNMSVFIEEAYKKLN 180 naked mole-rat
XP_003311370 211 ------lpelsqkTLKaptlQKEILALIPnqnALLRDLDIL-HNSSQMKSMSTFIEEAYKKLD 266 chimpanzee
XP_007238307 196 ------lpavsayRDDeptlQEQMMNMVP---NPEAVMKTL-QNCRVMRNTTAFLELAHKqad 248 Mexican tetra
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