1RG9,1O9T,5A1I,3TDE,3SO4,4LE5


Conserved Protein Domain Family
S-AdoMet_synt
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cd18079: S-AdoMet_synt 
S-adenosylmethionine synthetase
S-adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase, catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP in two steps, the formation of AdoMet and hydrolysis of the tripolyphosphate, which occurs prior to release of the product from the enzyme, which consists of three structural domains that have a similar alpha+beta fold.
Links
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Statistics
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PSSM-Id: 350837
Aligned: 227 rows
Threshold Bit Score: 412.952
Created: 23-Jun-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1RG9: Escherichia coli S-adenosylmethionine synthetase binds SAM (S-adenosylmethionine) and PPNP (imido-triphosphate), contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #     ###                       #              #                            
1RG9_A         4 LFTSESVSEGHPDKIADQISDAVLDAILEQDpkARVACETYVKTGMVLVGGEITTSawvDIEEITRNTVREIGYVHsdmg 83  Escherichia coli
Q9PQ77         6 IITSESVGAGHPDKICDQISDAILDECLAQDknSRVACEVLACNRLIVIAGEITTHayvDVVKTAWEIIKPLGYNEnd-- 83  Ureaplasma parvum
Q6KHY1         5 IFTSESVGKGHPDKICDQISDRILDSILKKDcnARVACEVMASNKLIVIGGEIKTNsyiDVVKEAWNILLKLGYDEnd-- 82  Mycoplasma mobile
WP_014335537   9 LSVSESVGKGHPDKICDQISDSILDAILAKDpnARVAVEVMASNRLIIIGGEVSTKayvDVVKTAWKVVFAIGYNEnd-- 86  Mycoplasma hyor...
WP_012751580   8 LSIAESVGKGHPDKICDQISDAILDNILKQDsnARVAIETMASNRLIIIAGEIKTHsyvDFVQIAWNIVKSLGYSEnd-- 85  Mycoplasma conj...
Q8EWV5         6 IMTSESVGKGHPDKICDQISDAVLDECLKQDpnSKVACEVFAANRLIVIGGEITTAgyvDVVKMAWNVLIPLGYDEsd-- 83  Mycoplasma pene...
Q4A9N7         5 ISVAESVGKGHPDKICDQISDAILDEILKQDehARVAVETMASNRLIIIGGEISTSgyvDLVKIAWEILFEIGYNEnd-- 82  Mycoplasma hyop...
Q7NB16        22 VYTAESVGSAHPDKLCDQIADAILDACLKQDqnSRVACEVMACNHLIIIAGEISTKasvDYVGTAWKVVNQFGYDRsd-- 99  Mycoplasma gall...
P47293        12 RFVSESVGLGHPDKICDQIADSILDQCLLQSktSHVACEVFASKNLILIGGEISTSgyvDVVQTAWRILRNLGYNEtd-- 89  Mycoplasma geni...
AEG73813       3 LRTSEAVGTGHPDKIADRVAEEIVEEVLKQDvrGRVACEVLVSRNLVAIAGEITTKaevNYEEVARKCLQGQGYDPse-- 80  Mycoplasma haem...

Feature 1                      #  ##              ##                                            #
1RG9_A        84 fdanscAVLSAIGKQSPDInqgvdradpleqgaGDQGLMFGYATNETdvLMPAPITYAHRLVQRQAEVRkngtlpwLRPD 163 Escherichia coli
Q9PQ77        84 -----fTIISNVNKQSVDIaqsvnkankdligaGDQGIVFGYACDETpqYMPLTTVLAHELLKEIEKQRrnkefvkIQAD 158 Ureaplasma parvum
Q6KHY1        83 -----fTIISNINKQSSDIsfgvdks-ngsiaaGDQGIVFGYATNETeqFLPLNFVIAHEILKIAEKKRlnktfqnAKSD 156 Mycoplasma mobile
WP_014335537  87 -----fTIISNVNTQSADIakkvdk--sdtlgaGDQGVVYGYACSETknFYPLSASLAHALTKYAEELRskkkfpyAKAD 159 Mycoplasma hyor...
WP_012751580  86 -----fTIISNVNSQSADIaqgvdke-sgligaGDQGIVYGYASKETtsYMPLAHTIAHELLKLAEKLRvsgdflwAKAD 159 Mycoplasma conj...
Q8EWV5        84 -----fTIISNVNSQSNEIfnavek--dnqigaGDQGVVYGYATDECenFMPLPINIAHDLVKCAEQVIwntkidfIKHD 156 Mycoplasma pene...
Q4A9N7        83 -----fTIISNVNRQSGEIaslvdqk-ngtigaGDQGIVYGFATNECpnFMPLAQNLANFLVKKAEELRkigefqfACAD 156 Mycoplasma hyop...
Q7NB16       100 -----fTIIANINQQSSEIaqsvdqk-nhkigaGDQGITVGYACDETknQMPLAVMMAHDLVRLAKELIdnktfnhAKYD 173 Mycoplasma gall...
P47293        90 -----fSFLSCINNQSLEInqavlk--nneinaGDQGITVGYAVNETkqLMPLGVLLAHSFLKQAEKLTkqf--dfLKND 160 Mycoplasma geni...
AEG73813      81 -----fRFAVDIKRQSPDIekasla---griksGDQCVVYGFAVDETdeLMPIAHSVARDLIIKTEDLIdkgklkwAKKD 152 Mycoplasma haem...

Feature 1         #                    #                                                # ## #   
1RG9_A       164 AKSQVTFQYddgkiVGIDAVVLSTQhse----eidQKSLQEAVMEEIIKPILpaew----ltsaTKFFINPTGRFVIGGP 235 Escherichia coli
Q9PQ77       159 MKSQVSIDYsn-ctPVIETMLVSIQhdedynieyfNKKVSTIMDQIAIKYGLnt---------dFKKIINSSGRFVIGGP 228 Ureaplasma parvum
Q6KHY1       157 MKSQVTMDYsdpknPKLVTIIVAIQhek----nidKDEFEKFIKDEIIYVVTdkyk----lnrnFEILINTAGDFTIGGP 228 Mycoplasma mobile
WP_014335537 160 MKSQVEVDFsnweqPKIVKMIMSVQhea----kidDKKFKQFIHKDIMQKIAqdyg----lnldFETIINPGGQFVIGGT 231 Mycoplasma hyor...
WP_012751580 160 MKSQVEIDFsn-qkPKINKIIMSVQhda----nydHQLFVSFIKEKIMKKVAvsfg----lntdFETLINTTGKFVIGGP 230 Mycoplasma conj...
Q8EWV5       157 MKSQVTIDYadsqnPKIDQIIMSVQhsqna-tkesIESFCNAIIDFVVKKYNln--------sdFKRIINNSGKFTIGGP 227 Mycoplasma pene...
Q4A9N7       157 MKSQVEIHYdqnskPKVKSMLMSIQhqq----nfnYHNFVEFVINKIMIPAAkkyn----lnidFEKKVNKSGDFTIGGP 228 Mycoplasma hyop...
Q7NB16       174 MKAQVSLNYldnnqVELKTILMSIQhee----nvdLSVFKLFVKKFIMDEVAtkyg----fnknYEALINPSGLFVSGGP 245 Mycoplasma gall...
P47293       161 MKSQVVLNYsl-nqVECEEVLLSIQhtn----aisLTELRKVIENNVILPVLnqygf---qdkkPTCLVNPGGSFVLGGP 232 Mycoplasma geni...
AEG73813     153 MKALVSIGMen-edYKLRSLLFSIQhte----dvdLEQIREDIFMKVLVPVVegnyslmmdrvsVWGNINRSGRFVIGGL 227 Mycoplasma haem...

Feature 1          #     ##             ###   #   # #                              #             
1RG9_A       236 MGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGlaDRCEIQVSYAIGva--ePTSIMVE 313 Escherichia coli
Q9PQ77       229 IGDTGLTGRKIIVDTYGGIGHHGGGAFSGKDPTKVDRSASYFARWIAKNVVAAKlaKQCEIQLAFAIGep--qPVAMFVN 306 Ureaplasma parvum
Q6KHY1       229 IGDTGLTGRKIIVDTYGGWARHGGGAFSGKDYTKVDRSGAYFARWVAKNLVAAEvaDKVEIQFAFAIGke--mPIAININ 306 Mycoplasma mobile
WP_014335537 232 IGDTGLTGRKIIVDSYGDRAHHGGGAFSGKDYTKVDRSGAYFARWIAKNLVAAGvaKELEIQLSFAIGia--ePISISVE 309 Mycoplasma hyor...
WP_012751580 231 IGDTGLTGRKIIIDSYGDRAHHGGGAFSGKDYTKVDRSGAYAARWVAKNLVAAGvaDEIEVQLSYAIGlp--ePTSIAIS 308 Mycoplasma conj...
Q8EWV5       228 IGDTGLTGRKLMVDTYGSLAKHGGGAFSGKDCTKVDRSGAYFARYIAKNIVAAKlaKKCEVQLSFAIGas--kPIAFAVD 305 Mycoplasma pene...
Q4A9N7       229 IGDTGLTGRKLIIDTYGDAAKHGGGAFSGKDYTKVDRSGAYIARWIAKNLVAAGvaAEIELQFAYAIGne--yPELINVT 306 Mycoplasma hyop...
Q7NB16       246 TADTGLTGRKLLVDSFGIYAHHGGGAYSGKDYTKVDRSGAYYARWIAKHIVKAKlaSQCEVIISWAIGlt--kPLDIVVN 323 Mycoplasma gall...
P47293       233 MADTGLTGRKIIVDTYGPYAHHGGGSFSGKDPSKVDRTGAYFARFIAKHIVSLGwaSECEVSISWVFSkp--nPQSITVK 310 Mycoplasma geni...
AEG73813     228 DADTGVSNRKIVVDTYGANTKHGGGGLCGKDLSKIDRVGAYYARWICKNFVAAGvcRMMELQLAYSFGaerpeIISIVVD 307 Mycoplasma haem...

Feature 1                                                                      
1RG9_A       314 Tfgt-ekvPSEQLTLLVREFFdlrPYGLIQMLdll-hpIYKETAAYGHFgr--ehFPWEKTD 371 Escherichia coli
Q9PQ77       307 Tfkt-nlvDEKKIFEAINKSFnfdIKTFINDLelw-ttKYLPVATYGHFgrddlnLSWEKLN 366 Ureaplasma parvum
Q6KHY1       307 Vtne--kyKIELIEKVVKNLFnfnVGEIIEKLdlk-kpIYEQVASFGHFgrndldLSWEKLD 365 Mycoplasma mobile
WP_014335537 310 Qiqa-gkfSEEQIVQCIKNVFntsVKGFVEDLelr-kpIYKQTATYGHFgrndidLPWERLN 369 Mycoplasma hyorhinis
WP_012751580 309 Qsge-rlfEESKLIDVVKKVFnlsVVNVINELglk-apIYQQTATYGHFgrddlnLPWESLN 368 Mycoplasma conjunctivae
Q8EWV5       306 Tfgt-skySDEQIYEIIVNTFdfsIKSFIEKFnmr-spIYSPFSTYGHFgrtelnPGWEQLD 365 Mycoplasma penetrans
Q4A9N7       307 Ylkn-akiPTVKIIEIIKNVFnlrLVSLISRLnlr-kpIYRNLAVYGHFgrdeldLPWEKLD 366 Mycoplasma hyopneumoniae J
Q7NB16       324 Cfnt-htvELDLINQIVKKIFnhdLATIIELLklk-ttNYSGLAVYGHFgksekqYRFEDTI 383 Mycoplasma gallisepticum
P47293       311 CfntniqyDEVLINRVVNNYFnwsITKIIDKLklldfvKYSDYAVYGHFgn--dlSPWEQPT 370 Mycoplasma genitalium G37
AEG73813     308 Sd-----eEEKEIRGAIEVIFpftVSELVDRFcfa-kfPCKDLVKNGHFgd--esLPWEKTD 361 Mycoplasma haemofelis Ohio2

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