Conserved Protein Domain Family
P2X

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TIGR00863: P2X 
cation transporter protein
ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273307
Aligned: 13 rows
Threshold Bit Score: 597.481
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q99571     1 MAG--CCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKVKGVAVTNTS 77  human
P51576     1 MARr-LQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSS-GLISSVSVKLKGLAVTQLQ 78  house mouse
P47824     1 MARr-LQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSS-DLISSVSVKLKGLAVTQLQ 78  Norway rat
P51575     1 MARr-FQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSS-GLISSVSVKLKGLAVTQLP 78  human
P51577     1 MAG--CCSVLGSFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKAKGVAVTNTS 77  Norway rat
CAA65993   1 MGQa-AWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLIILLYLLIWVFLIKKSYQDIDtSLQSAVVTKVKGVAYTNTT 79  Norway rat
AAB08577   1 MGQa-GCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDtSLQSAVITKVKGVAFTNTS 79  human
P51579     1 MASavAAALVSWGFLDYKTEKYVMTRNCWVGISQRLLQLGVVVYVIGWALLAKKGYQEWDmDPQISVITKLKGVSVTQVK 80  Norway rat
O54803     1 MASaaAAALVSWGFLDYKTEKYVLTRNCRVGVSQRLLQLAVVVYVIGWALLAKKGYQERDlAPQTSVITKLKGVSVTQVK 80  house mouse
O15547    11 MGS--PGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDlEPQFSIITKLKGVSVTQIK 88  human
AAC08993  10 TAQr-LRQG-WSAFWDYETPKVIVVRNRPLGVVYRAVQLLILLYFVWYVFIVQKSYQDSEtGPESSIITKVKGITQS--- 84  domestic guinea pig
CAA71499   1 MVRr-LARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSEtGPESSIITKVKGITMS--- 76  Norway rat
P56373     1 -------MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDtAIESSVVTKVKGSGLY--- 70  human
Q99571    78 KLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATt-VCKSDASCTAGSAGTHSNGVSTGRCVA-FNGS 155 human
P51576    79 GLGPQVWDVADYVFPAHGDSSFVVMTNFIMTPQQAQGHCAENPEGG--ICQDDSGCTPGKAERKAQGIRTGNCVP-FNGT 155 house mouse
P47824    79 GLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGG--ICQDDSGCTPGKAERKAQGIRTGNCVP-FNGT 155 Norway rat
P51575    79 GLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGG--ICKEDSGCTPGKAKRKAQGIRTGKCVA-FNDT 155 human
P51577    78 QLGFRIWDVADYVIPAQEENSLFIMTNMIVTVNQTQSTCPEIPDKTs-ICNSDADCTPGSVDTHSSGVATGRCVP-FNES 155 Norway rat
CAA65993  80 MLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPdgECSEDDDCHAGESVVAGHGLKTGRCLR-VGNS 158 Norway rat
AAB08577  80 DLGQRIWDVADYVIP------------------------AENEGIPdgACSKDSDCHAGEAVTAGNGVKTGRCLR-RENL 134 human
P51579    81 ELEKRLWDVADFVRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPlaNCWADEDCPEGEMGTYSHGIKTGQCVA-FNGT 159 Norway rat
O54803    81 ELENRLWDVADFVKPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPlaNCWADEDCPEGETGTYSHGIKTGQCVV-FNGT 159 house mouse
O15547    89 ELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPlaNCWVDEDCPEGEGGTHSHGVKTGQCVV-FNGT 167 human
AAC08993  85 --EHKVWDVEEYVKPPEGGSVFSIITRIEVTPFQTLGACPESIRVPntTCHLDADCTAGELDMLGNGLRTGRCVPyYHGE 162 domestic guinea pig
CAA71499  77 --EDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHssTCHSDDDCIAGQLDMQGNGIRTGHCVPyYHGD 154 Norway rat
P56373    71 --ANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESE--EkyRCVSDSQC--GPERLPGGGILTGRCVN-YSSV 143 human
Q99571   156 VK-TCEVAAWCPVEDDThVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGK 234 human
P51576   156 VK-TCEIFGWCPVEVDDkIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKILHPLCPVFSLGY 234 house mouse
P47824   156 VK-TCEIFGWCPVEVDDkIPSPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKIQHPLCPVFNLGY 234 Norway rat
P51575   156 VK-TCEIFGWCPVEVDDdIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGY 234 human
P51577   156 VK-TCEVAAWCPVENDVgVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAQTDPFCPIFRLGT 234 Norway rat
CAA65993 159 TRgTCEIFAWCPVETKS-MPTDPLLKDAESFTIFIKNFIRFPKFNFSKANVLETDNKHFLKTCHFSST-NLYCPIFRLGS 236 Norway rat
AAB08577 135 ARgTCEIFAWCPLETSS-RPEEPFLKEAEDFTIFIKNHIRFPKFNFSN-NVMDVKDRSFLKSCHFGPK-NHYCPIFRLGS 211 human
P51579   160 HR-TCEIWSWCPVESSA-VPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNALDTWDNTYFKYCLYDSLSSPYCPVFRIGD 237 Norway rat
O54803   160 HR-TCEIWSWCPVESGA-VPRKPLLAQAKNFTLFIKNTVTFSKFNFSRSNALLTWDNTYFKHCLYDPLSSPYCPVFRIGD 237 house mouse
O15547   168 HR-TCEIWSWCPVESGV-VPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGD 245 human
AAC08993 163 AK-TCEVSGWCPVEDGA-AVSHFLGKMAPNFTILIKNSIHYPKFQFSKGNIAH-RDMTYLRRCTFDQGFDPYCPIFRLGF 239 domestic guinea pig
CAA71499 155 SK-TCEVSAWCPVEDGT-SDNHFLGKMAPNFTILIKNSIHYPKFKFSKGKIAS-QKSDYLKHCTFDQDSDPYCPIFRLGF 231 Norway rat
P56373   144 LR-TCEIQGWCPTEVDT-VETPIM-MEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGD 220 human
Q99571   235 IVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTrdvEHNVSPGYNFRFAKYYRDLaGNEQRTLIKA 314 human
P51576   235 VVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQFHGLYG---EKNLSPGFNFRFARHFVQN-GTNRRHLFKV 310 house mouse
P47824   235 VVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYG---EKNLSPGFNFRFARHFVQN-GTNRRHLFKV 310 Norway rat
P51575   235 VVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYE---EKNLSPGFNFRFARHFVEN-GTNYRHLFKV 310 human
P51577   235 IVEDAGHSFQEMAVEGGIMGIQIKWDCNLDRAASLCLPRYSFRRLDTrdlEHNVSPGYNFRFAKYYRDLaGKEQRTLTKA 314 Norway rat
CAA65993 237 IVRWAGADFQDIALKGGVIGIYIEWDCDLDKAASKCNPHYYFNRLDNk-hTHSISSGYNFRFARYYRDPnGVEFRDLMKA 315 Norway rat
AAB08577 212 VIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNk-lSKSVSSGYNFRFARYYRDAaGVEFRTLMKA 290 human
P51579   238 LVAMTGGDFEDLALLGGAVGINIHWDCNLDTKGSDCSPQYSFQLQE---------RGYNFRTANYWWAAsGVESRSLLKL 308 Norway rat
O54803   238 LVAMAGGDFEDLALLGGAVGISIHWDCNLDTKGSDCCPQYSFQLQQ---------KGYNFRTANHWWAAsGVETRSLLKL 308 house mouse
O15547   246 LVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQE---------KSYNFRTATHWWEQpGVEARTLLKL 316 human
AAC08993 240 IVEQAGENFTELAHRGGVIGVIINWDCDLDLPSSHCNPKYSFRRLDp--kHVPASSGYNFRFAKYYRVN-STTTRTLIKA 316 domestic guinea pig
CAA71499 232 IVEKAGENFTELAHKGGVIGVIINWNCDLDLCESECNPKYSFRRLDp--kYDPASSGYNFRFGKYYKINgTTTTRTLIKA 309 Norway rat
P56373   221 VVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSvseKSSVSPGYNFRFAKYYKMEnGSEYRTLLKA 300 human
Q99571   315 YGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKY 372 human
P51576   311 FGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368 house mouse
P47824   311 FGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368 Norway rat
P51575   311 FGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368 human
P51577   315 YGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCMKKKYYYRDKKY 372 Norway rat
CAA65993 316 YGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKF 373 Norway rat
AAB08577 291 YGIRFDVMVN---GK-------------------GASFCDLVLIYLIKKREFYRDKKY 326 human
P51579   309 YGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKY 366 Norway rat
O54803   309 YGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKY 366 house mouse
O15547   317 YGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKY 374 human
AAC08993 317 YGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKVYSHKKF 374 domestic guinea pig
CAA71499 310 YGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKF 367 Norway rat
P56373   301 FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 358 human
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