1EFP,1T9G,1EFV,1O94


Conserved Protein Domain Family
ETF_beta
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cd01714: ETF_beta (this model, PSSM-Id:238847 is obsolete and has been replaced by 467487)
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The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.
Links
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Statistics
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PSSM-Id: 238847
Aligned: 63 rows
Threshold Bit Score: 170.035
Created: 2-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Ligand binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:Ligand binding site [chemical binding site]
Evidence:
  • Structure:1094_c, FAD binding sites defined by 3.5A distance
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ##                            #  #                           #              
1EFP_B        2 KVLVPVKRLIdynvkarvksdgsgvdlaNVKMSMNPFDEIAVEEAIRlkek----gqaeEIIAVSIGVkQAAETLRTALA 77  Paracoccus denit...
NP_737938     5 TIVVLVKNVPdtwskrtle-adftldreGVDEVLDEINEFALEQALRlrea----npghKVVALSAGPeSADEALRKALS 79  Corynebacterium ...
NP_377775     2 NIVTCFKIVPddtliki----vgdkldlNVPPKISTYDKNAIEEAVRikek-----yggKAIGVTAGN-TDRKSIREALA 71  Sulfolobus tokod...
P64097        3 NIVVLIKQVPdtwserkltdgdftldreAADAVLDEINERAVEEALQirekeaadgiegSVTVLTAGPeRATEAIRKALS 82  Mycobacterium tu...
NP_344084     2 NIIVGFKIVPddqmikv----vgdklntDAPLKVSTYDKNAIEEAIRlkek-----fggKVTGITVGN-NDRKSIREALA 71  Sulfolobus solfa...
AAD37460     19 RIVVCVKYVPdatgdrrfa-ddltldreDVDGLLSELDEYAVEQALQiadg----addaEITVVTVGPeDAKDALRKALS 93  Streptomyces gri...
NP_393689     4 NVAVLIKQIIdidqmktd--segkpiltGIPYRLENLSKNAIEAAVRikek-----yggKVTGIIFGTeAGTSAMKESYA 76  Thermoplasma aci...
ZP_00306268   2 DIAVLVKQTVdmdqikln--denepimdNLPLKMDILSKNAIEAAVQlkek-----ysgKVTGFIFGTeKSTSTMKEAYA 74  Ferroplasma acid...
1O94_C        2 KILVAVKQTAaleedfeiredgmdvdedFMMYDLNEWDDFSLEEAMKikess---dtdvEVVVVSVGPdRVDESLRKCLA 78  Methylophilus me...
ZP_00298397   2 QIVVLAKVVPdyevpsadfelvgnrahpRYTRMIGLYDENAVELGVQlkek-----lgaDLTVVSYGRnDDVQFLRKALA 76  Geobacter metall...

Feature 1                                                 ## ##    ####                         
1EFP_B       78 MGADRAILVVaaddvqqdIEPLAVAKILAAVARAEg-TELIIAGKQAiDNDMNATGQMLAAILGWAQATFASKVEieg-- 154 Paracoccus denit...
NP_737938    80 MGADEAILLTdga--lagSDLLGTAWALNNAINTIpdVSLIVAGAASsDGSMGALPGVLAEYRQVPALTGLSRVAieg-- 155 Corynebacterium ...
NP_377775    72 MGLDEVIAINmk-----ePDVMTTAEAIAETISPIk-PDIILTGESTtDSSTSVFSSYLASLLNYPVVTYAKSITieg-- 143 Sulfolobus tokod...
P64097       83 MGADKAVHLKddg--mhgSDVIQTGWALARALGTIegTELVIAGNEStDGVGGAVPAIIAEYLGLPQLTHLRKVSieg-- 158 Mycobacterium tu...
NP_344084    72 MGVDEVIAILvk-----dPDVYVTAMAIAENVKTLn-PDIILFSEMTtDSGTSALPAYVSELLGLPYISNVKSLKieg-- 143 Sulfolobus solfa...
AAD37460     94 MGADKAVHVEddd--lhgSDVMGTSLVLAKAVEKAg-YDLVICGMAStDGVMGVLPALLAERLGVPQVTLLSEVAvdg-- 168 Streptomyces gri...
NP_393689    77 MGVDEGILITgy----kgNNPQVTAKAILNYLKQIp-FDLVILGDQSaDSYTGMLPGLISAGLGIPLLGNANNIVvdg-- 149 Thermoplasma aci...
ZP_00306268  75 MGVDEGTVIKgy----qkSDPLVTAGVIAAELKKAk-YDIIILGDQSsDSYSGLLAGLLASELDLNVITNAINIEvkd-- 147 Ferroplasma acid...
1O94_C       79 KGADRAVRVWdda--aegSDAIVVGRILTEVIKKEa-PDMVFAGVQSsDQAYASTGISVASYLNWPHAAVVADLQykpgd 155 Methylophilus me...
ZP_00298397  77 MGADKVVLVEgd-----sDDPYVIAANLKDAIDRQgtVDLILAGRQSsDMDRGVVPGVLAGMLDLPFVPQACSVEsvd-- 149 Geobacter metall...

Feature 1                                                              
1EFP_B      155 akAKVTREv-dGGLQTIAVs-LPAVVTADLRLNEPRYAsLPNIMKAkKKPLDEKT 207 Paracoccus denitrificans
NP_737938   156 adVTGTRVd-hRGSFELKAa-LPAVVSITDKADKPRFPnFKGIMAAkKATIARLN 208 Corynebacterium efficiens YS-314
NP_377775   144 nkVRVERNl-tTFQEIVETd-LPAIISVVGEINTPRIPsVKQILESsKKPVKNID 196 Sulfolobus tokodaii str. 7
P64097      159 gkITGEREt-dEGVFTLEAt-LPAVISVNEKINEPRFPsFKGIMAAkKKEVTVLT 211 Mycobacterium tuberculosis
NP_344084   144 nkVVADRGm-vSYLETVESs-LPIIVSVGGEINTPRIPsVKQIMESsKKPVKEVK 196 Sulfolobus solfataricus P2
AAD37460    169 gvVTGRRDg-dTASEQLEAs-LPAVVSVTDQSGEARYPsFKGIMAAkKKPVESLD 221 Streptomyces griseus subsp. griseus
NP_393689   150 ktVRITQVg-eTENAEMESe-MPAVVSVKQEINEPRLPpVLQIMAAgRKPIRTEK 202 Thermoplasma acidophilum DSM 1728
ZP_00306268 148 kiANVTVEs-eNEDVTVETg-LPAVVSVAQEINEPRLPkVMQIMMAgKKNINIVD 200 Ferroplasma acidarmanus
1O94_C      156 nkAVIRRElegGMLQEVEIn-CPAVLTIQLGINKPRYAsLRGIKQAaTKPIEEVS 209 Methylophilus methylotrophus
ZP_00298397 150 ggWKISQIt-eTGKRLLKLsgKGVLSITSVPENVPRIPaVKAIFAAkKKPVEKLP 203 Geobacter metallireducens GS-15

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