4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.
Feature 1: putative active site [active site], 4 residue positions
Conserved feature residue pattern:d d d d
Evidence:
Comment:based on homology modeling using structures of trans prenyltransferases that are helical enzymes containing two D-rich motifs in the active site
Jiyao W et al.(2023). "The conserved domain database in 2023.",