Conserved Protein Domain Family
GP41
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pfam00517: GP41 
Retroviral envelope protein
This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).
Links
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Statistics
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PSSM-Id: 395415
Aligned: 4 rows
Threshold Bit Score: 182.875
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P18094       528 MGARSLTLSAQSRTLLAGIvqqQQQLLDVVKRQQEMlrltvwgTKNLQARVTAIEKY----------LKHQAQLNswgC- 596 Human immunodef...
P04578       530 MGAASMTLTVQARQLLSGIvqqQNNLLRAIEAQQHLlqltvwgIKQLQARILAVERY----------LKDQQLLGiwgC- 598 HIV-1 M:B_HXB2R
Q85646       477 VATTALVKEMQTATFVNNL---HRNVTLALSEQRII-------DLKLEARLNALEEVvldlgqdvanLKTRMSTR---Ch 543 Mouse mammary t...
XP_012023049 399 TASVSLAQSIQAAHTVDSL---SYNVTKVMGTQEDI-------DKKIEDRLSALYDVvrvlgeqvqsINFRMKIQ---Ch 465

P18094       597 -AFRQVCHTTVPW---------VNDSLSPDWKNMtwqewekQVRYLEANISQSLEEAQIQQEKNMYELQKLNSWD-ILGN 665 Human immunodef...
P04578       599 -SGKLICTTAVPWna-----swSNKSLEQIWNHTtwmewdrEINNYTSLIHSLIEESQNQQEKNEQELLELDKWA-SLWN 671 HIV-1 M:B_HXB2R
Q85646       544 aNYDFICVTPLPYnase-swerTKAHLLGIWNDN-------EISYNIQELTNLIGDMSKQHIDTVD----LSGLAqSFAN 611 Mouse mammary t...
XP_012023049 466 aNYKWICVTKKPYntsdfpwdkVKKHLQGIWFNT-------NVSLDLLQLHNEILDIENSPKATLNIADTVDNFLqNLFS 538

P18094       666 WFDLTS---WVKYiqygvhIVVGIIALRIAIYVVQLLsrfrkgyrPV-FssppgylqQIH-------IHKD------RG 727 Human immunodefi...
P04578       672 WFNITN---WLWYiklfimIVGGLVGLRIVFAVLSIVnrvrqgysPLsF--------QTH-------LPTP------RG 726 HIV-1 M:B_HXB2R
Q85646       612 GVKALNpldWTQY------FIFIGVGALLLVIVLMIF--------PIvFqclaksldQVQsdlnvllLKKK------KG 670 Mouse mammary tu...
XP_012023049 539 NFPSLHs-lWRS-------IIAMGAVLTVVLIIICLA--------PClIrsivkeflHMRvlihknmLQHQhlmellKN 601
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