5I08,5XLR


Conserved Protein Domain Family
Spike_NTD
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pfam16451: Spike_NTD (this model, PSSM-Id:406771 is obsolete and has been replaced by 465119)
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Spike glycoprotein N-terminal domain
The N-terminal domain of the coronavirus spike glycoprotein functions as a receptor binding domain. It binds carcinoembryonic antigen-related cell adhesion molecule 1.
Links
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Statistics
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PSSM-Id: 406771
Aligned: 30 rows
Threshold Bit Score: 183.688
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5I08_A         28 DVSLGLG--TYYVLNRVY-LNTTLLFTGYFPksGANFRDLalk------gsiYLSTLWYKPPFlsdFNNGIFSKVKNTKL 98   Human coronav...
ADM33558       39 KVTR-------LVPDPYVaYSGQTIRQSLYYadTSNVTVYpvtp-----yaaPDKTSIYNTSFv-mVNDGLFVHTYMYLN 105  Bat coronavir...
ADM33566       36 DMSAVSR--VF--PDPFVaYSGQTLKQSLYIadTSNTTVYpvtp-----pavNGKPGIYNLTIl-pVGDGFLVQTYMYKD 105  Bat coronavir...
YP_009273005   45 YVSVPLNklSCLLPDPYMaHSGQTVRQKLYMgnTSNTLVYpvtppmfnltygNVTPGVYNTSFlpvFD-GLLVHTYMNRF 123  Rousettus bat...
ANA96027       34 ISSGSRG--VYY-PDDIFrSNVSVLVTGRFLrfNTTLTWY------------NSWNQAYSSPVl-pFGHGVYFSTIDKSN 97   Bat coronavirus
5XLR_C         33 HTSSMRG--VYY-PDEIFrSDTLYLTQDLFLpfYSNVTGF------------HTINHTFGNPVi-pFKDGIYFAATEKSN 96   Severe acute ...
AGC74165       31 YSSTFRG--VYY-NDDIFrSDVLHLTQDYFLpfNTNVTRYlsl------naaQNTIVYFDNHVi-pFYDGIYFAATERSN 100  Bat coronavir...
AKZ19076       33 VSSSRRG--VYY-NDDIFrSDVLHLTQDYFLpfHSNLTQYfsl------siqSDKIVYFDNPIl-kFGDGIYFAATEKSN 102  Bat SARS-like...
ADE34779       33 VSSSRRG--VYY-NDDIFrSDVLHLTQDYFLpfDSNLTQYfsl------nvdSDRYTYFDNPIl-dFGDGVYFAATEKSN 102  Bat SARS coro...
AGC74176       33 FSSSKRG--VYY-NDDIFrSDVLHLTQDYFLpfHSNLTQYfsl------nvdSDRQVYFDNPTl-nFGDGVYFAATEKSN 102  Bat coronavir...

5I08_A         99 Yvnnt---lysEFSTIVIGSVFVNTS-YTIVVQPHN------------GILEITACqytmceyph--tvckskgsIR-NE 159  Human coronav...
ADM33558      106 Qpsnm---ycqDPFGVAFGTTFEQDHiAIVVIAPDNrgswtaaskrnvTTVHILVCsnatlcaypafnrwgpassIYaSD 182  Bat coronavir...
ADM33566      106 Qpsdt---ycqEPFGVAFGTTFEYDRiAIVTIVPGYkgswsavqkqttTNVNILVCsnatlcaypafnrwgpagtIYtTN 182  Bat coronavir...
YP_009273005  124 AhldnpnrtcqEPFGVVFGTTFEQDRiAMVIIAPGEfgmwgqvnrpntTFVHVVACsnaticaypmfnrwgpagsIHaEN 203  Rousettus bat...
ANA96027       98 Vvr-----------gWIFGTTLDNTT-QSALLVNNG------------SAITIEVCyfqfcdnp---afiisggaQTnTA 150  Bat coronavirus
5XLR_C         97 Vvr-----------gWVFGSTMNNKS-QSVIIINNS------------TNVVIRACnfelcdnpf-favskpmgtQThTM 151  Severe acute ...
AGC74165      101 Vir-----------gWIFGSTFDNRS-QSAIIVNNS------------THILVKVCnfvlcte-----pmftvsrNQhYK 151  Bat coronavir...
AKZ19076      103 Vir-----------gWVFGSTFDNTT-QSAIIVNNS------------THIIIRVCyfnlckdp---mytvsagtQI--S 153  Bat SARS-like...
ADE34779      103 Vir-----------gWIFGSSFDNTT-QSAVIVNNS------------THIIIRVCnfnlckep---mytvsrgtQQ--N 153  Bat SARS coro...
AGC74176      103 Vir-----------gWIFGSTMDNST-QSAIIVNNS------------THIIIRVCnfnlckep---mftvsrgvHF--S 153  Bat coronavir...

5I08_A        160 SWHIDsSEPLCLFKKn-fTYNVSAD---------WLYFHFYQERGVFYAYYA--------------DVGMPTTF-LFSLY 214  Human coronav...
ADM33558      183 AFVD--HGNSCFVNNs-fDIPINTS---------RINLAFRFLDGNLLLYHSrwlpg----sglnlATDYPLHF-FMSVG 245  Bat coronavir...
ADM33566      183 DFVV--YGDSCFINNt-fTISINTS---------RLNLGFRFNDGNLYLYHSkwlpm----qglnlMVDYPLHF-LMSVG 245  Bat coronavir...
YP_009273005  204 SFVE--HNSSCFLNDt-fEIPMGTS---------RVNLAFRFQDGNLLLYHTawlpt----enytlSGDYPLRY-ARSVG 266  Rousettus bat...
ANA96027      151 IYI---NLRNCTYVDtlrDLPLSFEdvdg-gfkhLREFVFKNSDGFLHIYGAyqpydlaigataalPAQFLPLKpLWKLP 226  Bat coronavirus
5XLR_C        152 IFD---NAFNCTFEYisdAFSLDVSeksg-nfkhLREFVFKNKDGFLYVYKGyqpid----vvrdlPSGFNTLKpIFKLP 223  Severe acute ...
AGC74165      152 SWVYQ-HARNCTYDVaypSFQLDVSlknnvnfqhLREFIFKNVDGFLKIYSSyepin----vvsgiPSGFSVLKpVMSLP 226  Bat coronavir...
AKZ19076      154 SWVYQ-NAFNCTYDRvekSFQLDTApksg-nfiaLREFVFKNRDGFFTVYQDytpvn----llrglPAGLSVLKpILKLP 227  Bat SARS-like...
ADE34779      154 AWVYQ-SAFNCTYDRvekSFQLDTTpktg-nfkdLREYVFKNRDGFLSVYQTytavn----lprglPTGFSVLKpILKLP 227  Bat SARS coro...
AGC74176      154 SWVYQ-SAFNCTYDRvekSFQLDTApktg-nfkdLREYVFKNRDGFLSVYHSytpvd----iirgiPVGFSVLKpILKLP 227  Bat coronavir...

5I08_A        215 LGTILSHYYVMPLTCN----Aissntdnet------leywvtplSRRQYLLNFDEHGVITNAVDCSSSFLSEIQCKTQSF 284  Human coronav...
ADM33558      246 VGANLPNAQFFQSVVR----Ynrgvdearcht--fqnnlyiaplSLREVLVSYSDSGLPLKVADCAADAGDELFCVTGSF 319  Bat coronavir...
ADM33566      246 VGANLPNMQFYQAVVRqgtpPvtgadkndanclafqnnlylayiSKRDLLVSYDDNGLPIAVADCSQNAGDELYCVTGTF 325  Bat coronavir...
YP_009273005  267 VGSNLPFAQFFQSVAR----Ardsacaflh------nnlyiapvQPKELLVKYNDQGMPVEIADCSADSTQELYCITGTF 336  Rousettus bat...
ANA96027      227 LGLNITNYKVVTTL-K----Ptnqafqa---------ayivgnlKHTTMMLSFNENGTMSNAIDCSQDPLAELKCTLKQF 292  Bat coronavirus
5XLR_C        224 LGINITNFRAILTAFS----Paqdiwgtsa------aayfvgylKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSF 293  Severe acute ...
AGC74165      227 LGINITGMRVVMTMFS----Ntqanflten------aayyvgylKPRTFMLQFNTNGTIVNAVDCSQDPLSELKCTLKNF 296  Bat coronavir...
AKZ19076      228 FGINITSFRVVMAMFS----Kttsnyvpes------aayyvgnlKQSTFMLSFNQNGTITDAVDCSQNPLAELKCTTKSF 297  Bat SARS-like...
ADE34779      228 FGINITSYRVVMAMFS----Qttsnflpes------aayyvgnlKYSTFMLRFNENGTITDAVDCSQNPLAELKCTIKNF 297  Bat SARS coro...
AGC74176      228 IGINITSFKVVMTMYS----Qttsnflses------aayyvgnlKYVTFMFQFNENGTIADAVDCSQNPLAELKCTLKNF 297  Bat coronavir...

5I08_A        285 APNTGVYDLSgfTVKPVATVYrRIPNLP-DCD 315  Human coronavirus HKU1 (isolate N5)
ADM33558      320 EPAIGVYPLSryRAQVSDYVHiTQQSQAcKLP 351  Bat coronavirus HKU9-5-1
ADM33566      326 SPQVGVYPLSryRALVSDYVQiSQQGSIcSLP 357  Bat coronavirus HKU9-5-2
YP_009273005  337 TPSVGVYQLSryRAEAKKLVQvTQQEDScAIP 368  Rousettus bat coronavirus
ANA96027      293 DVGKGIYQTSnfRVQPTVDVA-RFPNITnVCP 323  Bat coronavirus
5XLR_C        294 EIDKGIYQTSnfRVVPSGDVV-RFPNITnLCP 324  Severe acute respiratory syndrome-related coronavirus
AGC74165      297 NITKGIYQTSnfRVSPTQEVV-RFPNITnRCP 327  Bat coronavirus Rp/Shaanxi2011
AKZ19076      298 NVSKGIYQTSnfRVAPVTEVV-RFPNITnLCP 328  Bat SARS-like coronavirus YNLF_31C
ADE34779      298 NVDKGIYQTSnfRVSPTQEVI-RFPNITnRCP 328  Bat SARS coronavirus HKU3-9
AGC74176      298 NVSKGIYQTSnfRVSPSTEVI-RFPNITnRCP 328  Bat coronavirus Cp/Yunnan2011
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