Conserved Protein Domain Family
ICMT
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pfam04140: ICMT (this model, PSSM-Id:367837 is obsolete and has been replaced by 427740)
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.
Links
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Statistics
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PSSM-Id: 367837
Aligned: 12 rows
Threshold Bit Score: 90.4661
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P91402       171 WIGTlgCIIGEIFRKVGMVHAGLAFTHRLAMtkRSDHRLVKDGIYAYLRHPGYFGwFLWAVSTQIILCNP--ICCVVYAY 248 Caenorhabditis ...
Q9EWQ7        75 MLAL--ALSAQALRWWCIATLGPYWNTRVIV--VPGTRPVGAGPYRFLRHPNYLA-VVVEVAALPLVHSAwlTAAVFTAA 149 Streptomyces co...
Q9KF68        72 AIPFawFLFAQILRLWALSSLGRFWNTRIMI--LPDANVIASGPYRYIKHPNYAV-VIIEIAMLPLFFKAyvTAFLFSLL 148 Bacillus halodu...
O60725       161 VTGLlmVVFGECLRKAAMFTAGSNFNHVVQNekSDTHTLVTSGVYAWFRHPSYVGwFYWSIGTQVMLCNP--ICGVSYAL 238 human
P87014       121 ALGFl--CLGQYLRSSAMVQAGQSFSHIVASkrNKDHLLVTDGIYAYVRHPSYVGfFIWALGTQMLLGNF--VSTLLFSL 196 Schizosaccharom...
P32584       123 VLGCllVILGQYTRTIAMHTAGHSFSHIVKTkkESDHVLVKTGVYSWSRHPSYLGfFWWAIGTQLLLLNP--LSLVIFIF 200 Saccharomyces c...
Q9CM58        75 LAIL---VFAIAMLFYVIYELKEIWTVKLYI--LPEHHINRSFLFKYVRHPNYFLnIIPELIGLSLFCQAkyTALIGLPI 149 Pasteurella mul...
Q2G1E3        99 lV-I--LIFAYIMLFMVIKTLGGIWTLKLFI--LPNHPIIKSGLYKITKHPNYFLnIIPELIGVLLLTHAtyTTILLVP- 172 Staphylococcus ...
Q99YI2        81 LLLM---LLSVAVLYEVTRILGDIWTVKLML--AKDHKYVDHWLFKTIKHPNYFLnIAPELVGIALLCHAkiTAMLLFPC 155 Streptococcus p...
ACI98676      72 lLAL--FVLLQAGRVWVVASLGPYWTTRIIT--LPGAPLIRRGPFRHVRHPNYLV-VTGEIAVLPLAFGAweIALVFSFL 146 Rhodospirillum ...
Q9RTL5        91 ALLL--FLALQPLRYWVMHTLGRYWNTRILI--VPGGQRVTSGPFRFLGHPNYTV-VALELAAAPLAVGAwrTAVAFSLL 165 Deinococcus rad...
XP_002933887 169 gLIM--VLFGELLRKCAMLTAGSNFNHIVQNekSDSHTLVTSGVYSWFRHPSYVGwFYWSIGTQVLLCNP--LCLFGYTF 244 tropical clawed...

P91402       249 VTWHFFaSRIYDEEKDLIS 267 Caenorhabditis elegans
Q9EWQ7       150 NAMLLT-VRLRCENTALAQ 167 Streptomyces coelicolor
Q9KF68       149 NAIVLY-IRIHTEEEALQA 166 Bacillus halodurans
O60725       239 TVWRFFrDRTEEEEISLIH 257 human
P87014       197 VLWKFFsQRITTEEAYLVS 215 Schizosaccharomyces pombe 972h-
P32584       201 VLWKFFsDRIRVEEKYLIE 219 Saccharomyces cerevisiae S288C
Q9CM58       150 YLLILG-VRIKQEESAMAH 167 Pasteurella multocida
Q2G1E3       173 YAYFLY-VRIKQEEKLMNi 190 Staphylococcus aureus subsp. aureus NCTC 8325
Q99YI2       156 YIVVIY-LRIREENKLLAE 173 Streptococcus pyogenes serotype M1
ACI98676     147 NAALLF-HRIRQEERALAp 164 Rhodospirillum centenum SW
Q9RTL5       166 NAALLLgVRIPAEDRALAE 184 Deinococcus radiodurans
XP_002933887 245 ASWRFFrERIEEEEFSLIH 263 tropical clawed frog
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