?cl15079: PDS5 Superfamily (this model, PSSM-Id:417587 is obsolete)
Sister chromatid cohesion protein PDS5 Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",