1QLS,1NSH,1NSH


Conserved Protein Domain Family
S-100A11

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cd05023: S-100A11 
Click on image for an interactive view with Cn3D
S-100A11: S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins exhibit unique patterns of tissue- and cell type-specific expression and have been implicated in the Ca2+-dependent regulation of diverse physiological processes, including cell cycle regulation, differentiation, growth, and metabolic control . S100 proteins have also been associated with a variety of pathological events, including neoplastic transformation and neurodegenerative diseases such as Alzheimer's, usually via over expression of the protein. S100A11 is expressed in smooth muscle and other tissues and involves in calcium-dependent membrane aggregation, which is important for cell vesiculation . As is the case for many other S100 proteins, S100A11 is homodimer, which is able to form a heterodimer with S100B through subunit exchange. Ca2+ binding to S100A11 results in a conformational change in the protein, exposing a hydrophobic surface that interacts with target proteins. In addition to binding to annexin A1 and A6 S100A11 also interacts with actin and transglutaminase.
Statistics
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PSSM-Id: 240150
Aligned: 13 rows
Threshold Bit Score: 147.607
Created: 29-Dec-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1QLS_A, pig S100c bound with calcium ions, contacts at 3.5 A
  • Comment:the N-terminal EF hand is a S100 specific feature while the C-terminal canonical EF hand is similar to the EF hands in calmodulin, troponin C, and parvalbumin
  • Comment:the second binding site (C-terminal EF hand) has a greater affinity for Ca2+ than the first (N-terminal EF hand)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #  # #  #    #                                          # # # 
1QLS_A         5 PTETERCIESLIAIFQKHAGRDGNNTKISKTEFLIFMNTELAAFt--------qNQKDPg-----VLDRMMKKLDLDSDG 71  pig
1NSH_A         3 PTETERCIESLIAVFQKYAGKDGHSVTLSKTEFLSFMNTELAAFt--------kNQKDPg-----VLDRMMKKLDLNSDG 69  rabbit
1NSH_B         3 PTETERCIESLIAVFQKYAGKDGHSVTLSKTEFLSFMNTELAAFt--------kNQKDPg-----VLDRMMKKLDLNSDG 69  rabbit
P24480         4 PTETERCIESLIAVFQKYAGKDGHSVTLSKTEFLSFMNTELAAFt--------kNQKDPg-----VLDRMMKKLDLNSDG 70  rabbit
NP_005611      7 PTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMNTELAAFt--------kNQKDPg-----VLDRMMKKLDTNSDG 73  human
2827763        6 PTETERCIESLLAVFQRYAGREGDNLKLSKKEFRTFMNTELASFt--------kNQKDPa-----VVDRMMKRLDINSDG 72  chicken
O60417         7 PTETERCIESLIAVFQKYAGKDGYNRNLSKTEFLSFMNTELAAFt--------kNQKDP------GVLDHMKKLDVSSDG 72  human
XP_001108328   7 PTETEWCIKSLIAVFQKYAGKDGYNCSLSKTEFLSFMNTELFSFlntelaaftkNHKDP------SVLDRMKKLDVNSDG 80  rhesus monkey
XP_575255      2 PTETERCIESLIALFQKYNGKDKNSCQLSKTEFLSFMNTELATIr--------kNQKDPs-----VFDCMMNKLDLNSDG 68  Norway rat
XP_621386      2 PTETERCIESPIAVFQKCSRKEEKSYQLSKTESLSFMNIEMATTm--------nKQKDPg-----ALDQMMKKLNLNRDW 68  house mouse
BAD24044     117 PTDMESSMENIIRIFQKYAGKGGDKYQMDYKEFESFMKTELKTFt--------eGQKDPniv-qnLMKQMDGSVDDKKDG 187 African clawed ...
BAA34388       9 PTEMERSMEKIITVFQRYAGKEGNTTSMNFKEFEQFMNAELGSFt--------kNQKDPqailrkIMKSVDGGVDGKQDG 80  bullfrog
NP_001016706 116 PTEMETAMESIVRSFQKYAGKGGDKCQMDYKEFEGFMKTELKSFt--------eHQKDPnal-rsLMKTVDGSVDDKQDG 186 western clawed ...
Feature 1        #    #                
1QLS_A        72 QLDFQEFLNLIGGLAIACHDSF 93  pig
1NSH_A        70 QLDFQEFLNLIGGLAVACHESF 91  rabbit
1NSH_B        70 QLDFQEFLNLIGGLAVACHESF 91  rabbit
P24480        71 QLDFQEFLNLIGGLAVACHESF 92  rabbit
NP_005611     74 QLDFSEFLNLIGGLAMACHDSF 95  human
2827763       73 QLDFQEFLNLIGGIAVACHDAL 94  chicken
O60417        73 QLDFPKFLNLIGGLAVACHDSF 94  human
XP_001108328  81 QLDVPEFLNLIGGLAVACHDSF 102 rhesus monkey
XP_575255     69 HLDSQEFPNFIGGLAIACHESF 90  Norway rat
XP_621386     69 QLDFQEFLNLIDGLAIAWHEFF 90  house mouse
BAD24044     188 QINFQEFMNLVGGIMVSCQEAM 209 African clawed frog
BAA34388      81 ELDFQEFLNLIGGMMVACHEAL 102 bullfrog
NP_001016706 187 QLNFQEFMNLVGGIMVSCQHAM 208 western clawed frog

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