1K3R_A 1 MNRVDLSLFIPDSLTAETGDLKIKTYKVVLIARAASIFGVKRIVIYHDDADGE----------------ARFIRDILTYM 64 Methanothermobacter... 11499510 1 ----MLSIAIPSSALINERDEKIKTYKVGLIARAAAVFRVDEIIIYYDPILDE----------------SDFIAEILEYL 60 Archaeoglobus fulgidus 14600544 21 RRHNPLAVALPSSILRVEPTLLLKTLKAGQIGRVAAIYRVDEIAVFEDPDSSPr--------------lSRLLQLLLNYQ 86 Aeropyrum pernix 20093577 1 ----MVAVAFPWSLFSEETDPKIYAYRVGTLARALAIYRVEEVYLYGDGVGTRr--------------nAERLRKLLEYQ 62 Methanopyrus kandle... 14520559 1 ---MSWHVFIPDSLLEETNDPKLKAYKVGQIARACAIFGVEHIWIYKAGGRD-----------------GRLIKTLLEYA 60 Pyrococcus abyssi 18314060 1 ----MFSIAIPHDFLSEIPDEAGKVRKLGYLARAAAIFKAEYIIIYHYGTPRRe--------------dIDFAKTVLEYL 62 Pyrobaculum aerophilum 14591536 1 ---MSWHVFIPDSLLEETSDLKLKAYKVGQIARACAIFGVEHIWIYKAGGRD-----------------GRLIKTLLEYV 60 Pyrococcus horikoshii 19112370 13 TRRYTISLALPISSLNVAYNLQLKTSFVWKISRIVSLYGIDEIILLEDPEYVQntqvhtlssdaylkdpTKFLTDLLCYF 92 fission yeast 15897624 22 PRYKPLNVVLFLSIFDVENSLLEVTLKLSFILRVTTTFRVNKIYWITDSLNSRk--------------lEKIITDITKYA 87 Sulfolobus solfatar... 15790631 1 ---MTRSVLVPSSLVREAEDKREATRKLGYVARAAAVFRIDRVVVFPDEDGERqw-------------gGGFVETVLRYA 64 Halobacterium sp. N... 1723785 35 SNVVKYSICIPTTVIDNCNNLEQVTFTAYQIARTAVLFNVQEIIVLDQSKDKKhekksrs---ketisdCLLLATLLQYF 111 baker's yeast 2497224 15 SQTRHYSLCIPTTLVSDCRNLSQITHKVYQVAKFASLFNVSEVVILEDNSQVDatkk--------kistAKLILALLQYF 86 baker's yeast
1K3R_A 65 DTPQYLRRKVFPIMRELKH--VGILPPLRTPHHPTG-KPVTGEYRQGLTVKRVKKG-------------TLVDIGADKLA 128 Methanothermobacter... 11499510 61 ETPQYLRKHIFPLKKSLKY--AGLLPPLAIPSHRSK-HLKVGELREGVVRHVAPDGt------------RWVDVGIDALA 125 Archaeoglobus fulgidus 14600544 87 ATPPHLKKRVFPLRRELKY--ASLMPPLKIPSHTVPaEPKVGAILDGYVESCSGKS-------------CRVFLGSMGYG 151 Aeropyrum pernix 20093577 63 ECPQYLRKRVFRLDRDLRY--AGVMPPLRAPHHKVH-SPKEGEVREGYVVRRSRNG-------------ALVDVGADRLA 126 Methanopyrus kandle... 14520559 61 ETPQYLRKRLFPIMPELRY--AGVMPPLQIPSHKEKgSPRIGEIREGFAFRRGKK--------------LFADIGLDRPA 124 Pyrococcus abyssi 18314060 63 VTPPYLRKKVYKIDNRLKL--AGLLPPLKIPSHTVPvEPRIGEIREGIVERWDGYY-------------SLIYIGGGKYA 127 Pyrobaculum aerophilum 14591536 61 ETPQYLRKRIFPIMPELRY--AGVMPPLQIPSHKEKtSPRIGEIREGFAFRRGKK--------------IFADIGLDRPA 124 Pyrococcus horikoshii 19112370 93 ETPFFMRKELFPLNPHLKY--TSCFPLLPLRNDKAStVNIEFPYREGIVTHPSPQAkn----------kYIINAGLSHNV 160 fission yeast 15897624 88 LLPPYLKK-YVPISRNLKK--VGLMSPLGIPYHFIFkQAVEGEIRLGYKGDFGLN----------------K-------- 140 Sulfolobus solfatar... 15790631 65 ATPPYLRKEAFDTRDELAY--AGVLPPLRLSSWTGSdSSGSGSLRQGIVTQVGSEGr------------VRVNCGMQHPI 130 Halobacterium sp. N... 1723785 112 VTPPNLLDTTFKKKNKLYLkcASTFPPLNQLPFMNA--SAEQHYKEGLSIARDSSKgksd-----daltNLVYIGKNQII 184 baker's yeast 2497224 87 VTPPYLRNTVFNEKFRPYLtaASKLPRLSTLPFTRYqKQDHGRYREGLTIKMQKPTlarkkigkvfkqtKYINIGKSKAL 166 baker's yeast
1K3R_A 129 LCREK----LTVNRIMSFRVVRLG-----KEIL------IEPDEPEDrYWGYEVLDTRRn-LAESLKTVGAD--VVVATS 190 Methanothermobacter... 11499510 126 PMKSD----AEKGARVTVRICSK------TPLR------VEEAEPQE-YWGYRVKKLR---LEELVKRKNL----VV-TS 180 Archaeoglobus fulgidus 14600544 152 VLRGR----ARPGDVVTVRIGEISg----GRIV------LEKASWGElYYGFSVSRFKR--LEEAVTSFRRRgyRVVATD 215 Aeropyrum pernix 20093577 127 RTRWR----FKPHERVTVRIVSE------DPLE------VEPAEPEE-YWGYRVRIVNe--LNEVLREFKEG---IIVTS 184 Methanopyrus kandle... 14520559 125 LVKGI----ADEG-RGTFKIISV------KPLR------VVPAEPPG-YWGYKVHWSRKs-LVKTLKNADLD--VVIATS 183 Pyrococcus abyssi 18314060 128 KVPKP----YPIGTRLLVRIEGTTsrpdtYRAA------VYRGAPPD-YWGYKIDVRP---LQNLSEGFDT----VILTG 189 Pyrobaculum aerophilum 14591536 125 LVKGI----AEEG-RGTFKIISV------KPLR------VVPAEPPG-YWGYKVHWSKKs-LAKTLKNADLD--VVIATS 183 Pyrococcus horikoshii 19112370 161 IVSSPs--vLAPRTRVTVRLKAQSpn-eeGQLQgdivsfSAPREKGGhYWGYKVRSCLSsqLCKSSPYKGGYdfVVQINS 237 fission yeast 15897624 141 KLNSS----SK-----TILITDS-----------------LKAGYID-YRGFYYTGVKNe-FIDFKKVFNFDn--LIIAS 190 Sulfolobus solfatar... 15790631 131 SLHEPpgmaVSEGERVTIRVSSR------RPVR------AKLVDDPL--PGFSVERTG---LGDALDRSDAG--VRIATS 191 Halobacterium sp. N... 1723785 185 TLSNQn---IPNTARVTVDTERKev---vSP--------IDAYKGKP--LGYHVRMAST--LNEVSEGYTKIvwVNSGDF 246 baker's yeast 2497224 167 ALQSQl---VPINARVTIDTITRki---vSPQEa-----YGDFTGLDsQYGYYTRIASS--FTDLFMKGPLKe-gYTQSV 232 baker's yeast
1K3R_A 191 RNAspitsILDEVKTRMR----GAREAAILFGGPYKGLPEI---------------------DADIWVNTLPGQCTETVR 245 Methanothermobacter... 11499510 181 RK-------CEVVKPPA-----LRRDVTLVFGNPEEGVFEIakrl-------------gvemEAE-CWNVVPNQGTKTVR 234 Archaeoglobus fulgidus 14600544 216 KNGl---cPPESWKILAEi---PSAKTLVVFGGPYKGVLEYtn-----------------pyLYDGVVNVIPRQGTETVR 272 Aeropyrum pernix 20093577 185 RYG------EDVREVEF-----KSPVKCLVFGSSEVSVLDVdpg---------------vrdEYP-VINFVPNQGVQVVR 237 Methanopyrus kandle... 14520559 184 RRG------VDVRDAEVP----LEGEVGIVFGSPRKGVFEIlkef-------------neryEFDLVLNTIPGQKTKTVR 240 Pyrococcus abyssi 18314060 190 KEG------KSICEAKPK----IGKKTLVVFGGPRKGVDEIfrea-------------glepPGE-LINFAPGQGVETIR 245 Pyrobaculum aerophilum 14591536 184 RRG------VDVRDAEVP----LEGEVGIVFGSPRKGVFEIleef-------------kekyEFDLVLNTIPNQKTRTVR 240 Pyrococcus horikoshii 19112370 238 QTS-----AITSKELEAS----LPSSFRHAVLVLQDNVVQKelv---------------dstAKSISFNPFPVSFLNDPI 293 fission yeast 15897624 191 RSGk---nPLQAKEQLTNl--yNKYGLTLMIGPPTGNLLQRlg-----------------kqYLDKSYNFVIKQGVSDIR 248 Sulfolobus solfatar... 15790631 192 RHGe----PLSVASLGGYreriARDGVTVAFGAPERGLPPMlgvsadavnesvtdssadapaRFDAWLNTIPDQGSEVVR 267 Halobacterium sp. N... 1723785 247 HYDee-lsKYHKVETKLPy--iAKLKKSSTSEKPCNILLIFgkwghlkr------cfrrsdlESSSLHHYFSGQLQFPAS 317 baker's yeast 2497224 233 YVP------LTTRDTSIP----ELSSLPTAETNPHILLVFStwdtla----------rafklDQDQFVDCQGPQEFFDAQ 292 baker's yeast
1K3R_A 246 TEEAVLATLSVFNMLTQIDEKD 267 Methanothermobacter thermautotrophicus 11499510 235 LEEAIFATLSLVNFADYWGGLE 256 Archaeoglobus fulgidus 14600544 273 TEEALLATLEAISVLESLRQSS 294 Aeropyrum pernix 20093577 238 TEEAVHTTLAVLNYLGLI---- 255 Methanopyrus kandleri AV19 14520559 241 TEEAVLATLAIFNFMRRD---- 258 Pyrococcus abyssi 18314060 246 TEEAVFIVLSILNYIAKCSYKR 267 Pyrobaculum aerophilum 14591536 241 TEEAVLATLAIFNIMRRD---- 258 Pyrococcus horikoshii 19112370 294 PEEILLAAMTRLSDMLLMHGRR 315 fission yeast 15897624 249 AEEALAYSLSILNLLLS----- 265 Sulfolobus solfataricus 15790631 268 TEEAVLATLGSLTLTE------ 283 Halobacterium sp. NRC-1 1723785 318 VPQGNIPIQDSLPIALTMFQRW 339 baker's yeast 2497224 293 LPCPVSNSDVADAIPMTLTTLS 314 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",