pfam15427: S100PBPR (this model, PSSM-Id:373837 is obsolete and has been replaced by 464711)
S100P-binding protein
S100PBPR is a family of proteins found in eukaryotes, and localized to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.
Jiyao W et al.(2023). "The conserved domain database in 2023.",