2IXN,2IXO


Conserved Protein Domain Family
PTPA

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pfam03095: PTPA 
Phosphotyrosyl phosphate activator (PTPA) protein
Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognized phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1.
Statistics
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PSSM-Id: 460802
Aligned: 247 rows
Threshold Bit Score: 258.553
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IXN_B                3 PEKRLLTPDDMKLWEESPTRAHFTKFIIDLAESVKGHENsqykepiSES-----------INSMMNLLSQIKDIT----- 66  baker's ...
XP_003245316         43 VCQRVREPRDMFDWERSEARADLLVFVRHMNDVAKryp-----aaaAARrrrrprpfddnVDRAMAVLRTVGEWAvkrcg 117
ETN57795             17 PEKKIKSAMDMAKWEKSEAYYDLLGFISSMSVALQGTRAsqn-levSPV-----------VEKLMNAIDRLEQLA----- 79 
Q17M03               15 PEKLIKTRADMELWERSEAYYDVFGFISSMCVALQGTKQsqp-lelSPI-----------IEKLIEALKRLEQLA----- 77  yellow f...
EDW35372             30 PKRQVLCLEDMDDWVRSQAYKDTIAYINNTSMAIQGKKLsse-fpvSEK-----------VRRLCDIFDGLEILL----- 92 
WGS:AAPP:GF19862-PA  27 PVKQVRSLEDLDRWVRSQAFYDTIAYISNTSMAIQGRRLtre-fpiSEQ-----------MRKLCQIFDGLEHLL----- 89 
XP_002044198         27 PVKQVRSLEDLDRWVRSQAYYDIIAYISNTSKAIQGHRLtqa-fpvTEQ-----------MRRLGEIFDGLEQLI----- 89 
XP_002073342         33 AVTRVRKLSDVEVWKRSVGYHKLIAYINNTSSVIQGIRQsdd-ypvSET-----------MSRLLTIFDKLENLL----- 95 
Q9VNG7               23 PVCRVQSSSDMEAWLASRAYFTLITYLNDVSAEIQGIRNtdl-fpiSKN-----------IKRLTTIFEQLDSMI----- 85  fruit fly
XP_001955226         25 PHNRVETPADMEFWQQSKAYVILTTYLFDVSSHVQGVRTtdp-fpvSRS-----------IKRLLGIFDALDVLI----- 87 
2IXN_B               67 ----QKHPVI-K-Dad------sSRFGK------------VEFRDFYDEVSRNSRKILRS--EFPslTdeQLEQLSIYLD 120 baker's ...
XP_003245316        118 pagqDDRPESaA-----------ERFCH-----------------FHSQLRADGRCLLNRtyGGRgraeyRDVMLPAYLE 169
ETN57795             80 ----VETPPIdQ-P---------ARFGN------------AAFKTWFQKMRSESTQLIADalPETakE--AVKELQVYFE 131
Q17M03               78 ----IETPPVdQ-P---------ARFGN------------IAFRSWFQKMQGETAKLIEQaiPEHlkD--AVPELNVYFQ 129 yellow f...
EDW35372             93 ----SENTP---------------KFESahswltaqqgnaNAYRNWMRLMHQFVFSVLDEavQPEck---hINELGQYLR 150
WGS:AAPP:GF19862-PA  90 ----VEHSP---------------KSEDydtsisisqvksRAYRVWMRHMFQHVFFKLDEaiKAKck---hINELGQYLR 147
XP_002044198         90 ----VEHTP---------------KMEDsnlalpfgqvrsKAYRTWMRQMYQHVFSKLDEaiNVNck---hINELGQYLR 147
XP_002073342         96 ----AANPPIyM-AgsikgsldkDRRGN------------PAYRNWSRHMLRDIFPILEQavSNKnc--ihINELGQYLC 156
Q9VNG7               86 ----VANSPApLvLgan----mdSRT--------------KSYRRWAHGMLRDIYKIVEKavPSSkc--rhVNELGVYLS 141 fruit fly
XP_001955226         88 ----VANPPVvTgEpkt----smTESGN------------RAFRKWARCMLRDIYYMVEKavPTKkc--qhVNELGQYLS 145
2IXN_B              121 ESWGNKRRIDYGSGHELNFMCLLYGLYSYGIFNlSNDSTNLVLKVFIEYLKIMRILETKYWLEPAGSH-----GVWGLDD 195 baker's ...
XP_003245316        170 RSFGDPVTMAYGPAHELSFCAFLVSLFKLHHLtw-aDEPFVVTVIFDKYLDVVDYVIRSYQLYPSSSEyggnlGNWCLSG 248
ETN57795            132 ESFGNSTRIDYGTGHELAFVMFLMCLFKIGAIE-RKDEVAVGLKLFDKYIILVRKLQVTYRMEPAGSH-----GVWSLDD 205
Q17M03              130 ESFGNATRIDYGTGHELSFIMFLMCLFKIGAIE-RKDEVAVGLRLFVQYLNFVRKLQVTYRMEPAGSH-----GVWSLDD 203 yellow f...
EDW35372            151 RSFGCSSSLEFGPGNELMFLFFLCGLFRAGILfa-dDTVAAALLLFHRYIRLVRRLILTYSLSLTKD------SRFSMDD 223
WGS:AAPP:GF19862-PA 148 RSFGNATSLDFGPGNELMFLFFLCGLFRSGILla-kDTVAAALMLFGRYIHLVRRLVTTYALPIAKNP-----RSF-IDD 220
XP_002044198        148 RSFGNANTLDFGPANELMFLFFLCGLFRAGILla-kDTVAAALMLFNRYVNVVRRLISTYGLTIAKDP-----ACT-IED 220
XP_002073342        157 ESFGNSTRMSYGTGHELSFLFFLCALFEAEILde-dDLAASALLLFDRYLKFVRRLQVLYNLYAAGRH-----GAYSLDD 230
Q9VNG7              142 GSFGSSAKIEYGTGHELSFLFFVCALFKAEILdkeQDLAASALVLFDRYLHFVRRLQVTYSVNSSNWH-----GGYSLDK 216 fruit fly
XP_001955226        146 SSFGNSTKIEYGTTHELNFLFFVAGLFQARILnkeEDLAASGLILFVRYLKLVRRLQITYSMVPPANH-----GAYSLDK 220
2IXN_B              196 YHFLPFLFGAFQLTTH------------KHl-kPISIHNNELV-EMFAHRYLYFGCIAFIN-KVKSsasLRWHSPMLDDI 260 baker's ...
XP_003245316        249 YQFVGFLWGSAQLAGScgdgdgsapdgiPSlssPTAVISDAYAcRRHRDDYVFAKCMDAVYrRARKdvpLWYHSYQLWNL 328
ETN57795            206 FQFVPFIWGSAQLAVN------------SPi-ePAQFVEDKSI-DKYRKELMFVGCIDYIR-QVKTg-hFAEHSNQLWSI 269
Q17M03              204 FQFVPFIWGSAQLAVR------------SPi-ePAQFIEDNII-DVYRKEYMFVSCIDYIR-QVKTg-hFAEHSNQLWSI 267 yellow f...
EDW35372            224 YYVIPYIWGSAQLSLDa-----------PFs--PMESEMQLIM-EAHRQDYMLLEVIDHLR-KTRGl-qLNQVAFQLWCI 287
WGS:AAPP:GF19862-PA 221 YYVLPYLWGAAQLSSEe-----------LFs--PIQCEQPKLI-ENYRQDYMMMELIEHLQ-KTRGg-qLSHVAFQLWCI 284
XP_002044198        221 YYFLPYLWGAAQLSLNs-----------PFs--PMQCEQGKIM-DSYRQDYMMLEIIDHLQ-KTRRg-pLSRVALQLWSI 284
XP_002073342        231 FQFVPFLWGCAQLSYN------------APf-vPNRMLDADVV-SEYKKDYMLMGCVGHIS-DTKDg-tFAMHSSQLWCI 294
Q9VNG7              217 FQFVPFVWGFAQLCHEa-----------PFs--PKKMLDEDTI-AKYRDAYMLINCVGHMA-TTNVg-tFARHSSQLWSL 280 fruit fly
XP_001955226        221 FQFIPFIWGAAQLCYDa-----------PFs--PRKMLDEDTV-AKYKNSYLLADCVGHIM-MTNIg-pFAGHSSQLWCL 284
2IXN_B              261 SGVKTWSKVAEGMIKMYKAEVLSKLPIMQHFYFSEFLPC 299 baker's yeast
XP_003245316        329 TALPRWDRVNGCLITAYQRDVLGRFEVIRQLAFCELFKF 367
ETN57795            270 SAVPQWSKISTGLLKMYQKEVLSKFPVIQHVFFGSILTL 308
Q17M03              268 SAVPSWAKISTGLIKMYQKEVMSKFPVIQHVYFGSILTL 306 yellow fever mosquito
EDW35372            288 LSVPTWPEVYGAIERAYVSNVLSSFETVENAIFCELMSF 326
WGS:AAPP:GF19862-PA 285 LSIPSWSQVYRGLERNYISHVLSSFETVENAIFCELMSF 323
XP_002044198        285 LSIPTWPQVYRGLNRNYVDHVLSSFGTVEQAIFCELMSF 323
XP_002073342        295 ASLSSWNELYGGLLDMYDKVVLRQFDLMQLARFGQLISF 333
Q9VNG7              281 AALSSWTKIHRSLMFMYMEDILMDIDNLNALRFGELMSF 319 fruit fly
XP_001955226        285 AALSQWPDIYRGLIFRYTEDIVVDFDLIQPMRFGALMPF 323
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