5B5K


Conserved Protein Domain Family
IZUMO
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pfam15005: IZUMO (this model, PSSM-Id:405662 is obsolete and has been replaced by 464437)
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Izumo sperm-egg fusion, Ig domain-associated
This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilisation. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.
Links
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Statistics
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PSSM-Id: 405662
Aligned: 33 rows
Threshold Bit Score: 124.672
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5B5K_A         1 CIKCDQFVTDALKTFENTYLNDHLphDIHKNVMRMVNHEVSSFG---VVTSAEDSYLGAVDENTLEQATWSFLKDLKRIT 77  house mouse
A6QL94        23 CLECDPKFIEEVKSLLGKLVPPEV--PGRTHMLERQMKEMIRLS---FKVSHRDKMLRVLAVQKVVDLRTWLKIELDKLS 97  cattle
A6PWV3        23 CLECDPKFTEDVRTLLGNLVPLEV--PDRNQLLDRQHKEITHIS---SKVSHKDKMLRLLAVRNVIKLREWLKDEFYRLG 97  house mouse
XP_021588020  23 CLECDPKFIEDIRTLLTNLVPSEV--PGRNQLLERQFKETIHLS---SKVSHGNKMLRVLAVQKVVKLRTWLKNEFYRLG 97  thirteen-lined ...
Q5VZ72        21 CLECDPKFIEDVGSLLGNLIPSEV--PGRTQLLERQIKEMIHLS---FKVSHSDKRLRVLAVQQVVKLRTWLKNEFYKLG 95  human
XP_006908406  23 CLECDPKFIEDIKSLLAKLVPSEI--PGQTHLLERQIKEMINLS---FKVSHGNKMLRVLAVEKAVNLRIWLKNELSKLG 97  black flying fox
EGW13441      20 CLHCDQSVLHALRQLREATVPKRF---HLEGLQARAQALLLGMEgpfFRDYAVNAFVGKVEEDQLEDVATSFKNQTRYIR 96  Chinese hamster
XP_006229025  21 CLQCDQSVLEALHQLREAIIPKRF---HVEGLQARAQALLLSMEgpfFRDYAMNAFVGKVVLDQLETVVTSFKNQTQYIQ 97  Norway rat
XP_010586350  23 CLECDPKFIEDVRTLIENMVPPEV--PGRNYLLERQIKEMTHIS---SKFSHRDKMLRVLDVQNVVNLRSWLIQQFETLG 97  African savanna...
XP_006093586  23 CLECDPRFIKDIQSLLAKLVPSEV--PGRTELLDRQIKAMTNLS---FKVSHRNKMLRVLAVQRVVYLRTWLKNELYKMS 97  little brown bat

5B5K_A        78 DSDLKGELFIK-ELLWMLRHQKDIFNNLARQFQKEVLCPNKCGVMSQTLIWCLKCEKQLHICRKSLDC 144 house mouse
A6QL94        98 KEKWKGVFILQgRLLDIRKNLDSKLEKLLKKFSE-VACSEDCVVTEGPILDCWTCLRITSRCFRGEYC 164 cattle
A6PWV3        98 NETWKGVFIIQgNLLEIRQNLEKKLTQIIKNFSE-VACSEDCIVIEGPVLDCWNCLRMTTRCFKGDYC 164 house mouse
XP_021588020  98 NETWKGVFIFQgKLLEIRQKLEPKVKETLTAFSEV-------VVTEGPVLDCWTCLRITTRCFRGEYC 158 thirteen-lined ground squirrel
Q5VZ72        96 NETWKGVFIYQgKLLDVCQNLESKLKELLKNFSE-IACSEDCIVVEGPILDCWTCLRMTNRCFKGEYC 162 human
XP_006908406  98 NETWKGGFILQgKLLDVRQNLESKLKEILKKFSEV-------VVIEGPILDCWTCLRITTRCFKGEYC 158 black flying fox
EGW13441      97 TSSLTDGPLLE-ELVNLREHGIKTLKKALKAYEVK-------GFLKEEVLDCLHCKKITPKCIKEKYC 156 Chinese hamster
XP_006229025  98 ANSRTDGPLLE-ELVSFREHAIKELKKALRDYEIKACDHKTCHSFKEDILDCFYCKKTIAKCVKKKSC 164 Norway rat
XP_010586350  98 EGTWKGAFILQgKLLEIRQNLESKMKETLKTFSE-V------VVTEGPVLDCWTCLRITTHCFRGEYC 158 African savanna elephant
XP_006093586  98 NKTWKGVFILQgKLLDVRQSLESKLKEVLKHFSE-A------VLNEGPILDCWSCHQITTHCFKGEYC 158 little brown bat
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