3C2E,4KWW,1QPR


Conserved Protein Domain Family
nadC

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TIGR00078: nadC 
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nicotinate-nucleotide pyrophosphorylase
Synonym: quinolinate phosphoribosyltransferase (decarboxylating) [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Statistics
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PSSM-Id: 272894
Aligned: 18 rows
Threshold Bit Score: 333.839
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3C2E_A        16 DVTNWLSEDVP-----SFDFGg---yVVGSDLKEANLYCKQDGMLCGVPFAQEVFNQCe----LQVEWLFKEGSFLEPSK 83  baker's yeast
AAK41267       9 RLLDYLEEDVM-----PEDITt---kFLEGIRARGIVRCKDSGILAGNRFIVPFLKYLg----FSNINGEKDGREVKKGD 76  Sulfolobus solf...
P74301        24 WLQQWLAEDIG-----RGDWStqglgLQHRGQAR--WVAKENGVIAGLPMAARIFQLLdp--sMEFQVLAGEGQAVTAST 94  Synechocystis s...
WP_010897387   9 ALDRFFLEDGF-----NGDITtt-aiFPPSEKCVAHVKAKARGIVSGLSLLEIGYSLLdd--hIHVEERVKDGQEVRPGD 80  Bacillus halodu...
WP_012560417  16 TLKAALREDVH-----SEDYStn-aiFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFdxevtFQNPHQFKDGDRLTSGD 89  Streptococcus p...
WP_005874560  11 LIDLAIAEDIA-----DGDISsn-aiIPQSEGAAATMVMKADGIISGMEVARRVFERFe---aVTWTPYVSDGGSVKRGQ 81  Porphyromonas g...
WP_010880528   9 kLKEFLLEDIG-----TGDITte-giYRGE-KAKAVIKTKEEGVLAGAPFVEMVFEILg---gVSVEFKKREGEVFEKGE 78  Aquifex aeolicus
O27860         4 IIREMIRADVG-----FEDITte-alIDRGTRVVADIVSREEGVVAGVEVAEMMAREFs----ISIIRWKDDGDPLSGGE 73  Methanothermoba...
WP_001307569  40 AVAQALREDLGgtvdaNNDITak--lLPENSRSHATVITRENGVFCGKRWVEEVFIQLag-ddVTIIWHVDDGDVINANQ 116 Escherichia coli
WP_010884131   9 YLLRFVYEDSP-----YGDVTse-aiIPEDMNAEAVIIAKQDGVIAGVEEARVLFEHFg----VKVNVLKKDGEYVKKGE 78  Pyrococcus hori...
3C2E_A        84 ndsgkiVVAKITGPAkNILLAERTALNILSRSSGIATASHKIISLARSTGykGTIAGTRKTTPGLRRLEKYSMLVGGCDT 163 baker's yeast
AAK41267      77 ------IVLNFEGDA-DILTVERLILNFLGKLSGIATITNLMVKKAKEVNpyVRIAGTRKTTPGFRLFEKYAIEVGGGDP 149 Sulfolobus solf...
P74301        95 ------VVATMAGNLgSLLTGERVALNLVMGLSGIATMTRQYVQAIADYP--TRFVDTRKTTPGLRVLEKYASRLGGAMN 166 Synechocystis s...
WP_010897387  81 ------VIATIQGPVhHVLFGERVLLNLIQRMSGIATVTRKAIDTLNDPS--IRICDTRKTTPGLKLFEKYAVRSGGGYN 152 Bacillus halodu...
WP_012560417  90 ------LVLEIIGSVrSLLTCERVALNFLQHLSGIASMTAAYVEALGDDR--IKVFDTRKTTPNLRLFEKYAVRVGGGYN 161 Streptococcus p...
WP_005874560  82 ------VILRVEGSYrALLQAERLALNFLQRMSGIATMTARYAEALKGTA--VRLLDTRKTAPGMRITDKMAVRHGGGHN 153 Porphyromonas g...
WP_010880528  79 ------ILAILEGDAkSLLIGERLSLNILQRLSGIATTARKFVEKLKGTN--VKILDTRKTTPGFRYFEKYAVRIGGGTN 150 Aquifex aeolicus
O27860        74 ------RVLTLEGDAmDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNegIRIAATRKTTPGLQWFEKQAVRIGGGDT 147 Methanothermoba...
WP_001307569 117 ------SLFELEGPSrVLLTGERTALNFVQTLSGVASKVRHYVELLEGTN--TQLLDTRKTLPGLRSALKYAVLCGGGAN 188 Escherichia coli
WP_010884131  79 ------VIAEVKGNArAILLVERTALNIIGRMSGIATETRKLVEKVRKVNprVKVAGTRKSL--LRLIDKRAIMIGGGEP 150 Pyrococcus hori...
3C2E_A       164 HRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAVKIEVECLSEDEATEAIEAGADVIMLDNFKGDGLKMCAQS---- 239 baker's yeast
AAK41267     150 HRYNLSDAVLIKDNHITLYGNLEELIKRVKFSVSFTKIIEVEVSSYEDAIRAFKAGADVILLDNMKPYEILPIVNE---- 225 Sulfolobus solf...
P74301       167 HRLGLDDAVMVKDNHIQAAGSITKAVQTLRQNLPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKL---- 242 Synechocystis s...
WP_010897387 153 HRLNLSDMVLIKDNHIAQAKGIRQAVTQARSVIGHSLKIEVEVENREQLEEAVDAGVDIIMFDNMPPHIIKEYVAL---- 228 Bacillus halodu...
WP_012560417 162 HRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITL---- 237 Streptococcus p...
WP_005874560 154 HRMGLYDMIMLKDNHIKVAGGIPQAIEAARRALPLSIKLEVETSNLAEVEEAVRYGADIIMLDNMDNDTMCEAVRL---- 229 Porphyromonas g...
WP_010880528 151 HRFGLYDMVLIKDNHKRVAGSIKEAVKRVRERISPVYKIEVEVENLEEVEEALSAGVDVIMLDNFTPEEVKRAVEI---- 226 Aquifex aeolicus
O27860       148 HRFRLDDCAMIKDNHIAIVGNIEDAVRRVRDHVSFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEE---- 223 Methanothermoba...
WP_001307569 189 HRLGLSDAFLIKENHIIASGSVRQAVEKA-SWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETEQMREAVKR---- 263 Escherichia coli
WP_010884131 151 HRFSLSDAILIKDNHLALVP-LEEAIKRAKE-FSVYKVVEVEVENLEDAVKAAKAGADVIMLDNMKPQEIKEVIEKlrel 228 Pyrococcus hori...
3C2E_A       240 -LKNKwngkkhFLLECSGGLNLDNLEEYLCDDIDIYSTSSIHQGTPVIDFSLKL 292 baker's yeast
AAK41267     226 -LKSK------VLLEASGGITPDNVIDYAKTGVDVISSGYITHSYRSLDFSLDV 272 Sulfolobus solfataricus P2
P74301       243 -IRQAnp---lIRIEASGNVTLANLTAIASTGVDFISSSAPITRSPWLDLSMQI 292 Synechocystis sp. PCC 6803 substr. Kazusa
WP_010897387 229 -VPDG------IVTEASGGISLQTIASYRGCGVDYLSLGFITHSAPILDFTLLI 275 Bacillus halodurans
WP_012560417 238 -IAGR------SRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKg 284 Streptococcus pyogenes
WP_005874560 230 -IAGR------ARTEASGNMTLERLQSVAETGVDYISVGALTHSVTAMDISMNF 276 Porphyromonas gingivalis
WP_010880528 227 -IKGR------ALVEVSGNITLDNVLDYAVEGVDFISSGAIVHSSRWLDISLKF 273 Aquifex aeolicus
O27860       224 -LERRglr-dnVIVEASGGIKPDNIELYASTGVEVISMGFITASAHPVDLSLEI 275 Methanothermobacter thermautotrophicus st...
WP_001307569 264 -TNGK------ALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRF 310 Escherichia coli
WP_010884131 229 gLRDG------VKIEVSGGITPENIEEYAKLDVDVISLGYLTHSVRNFDVSLEI 276 Pyrococcus horikoshii
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