1BYQ,4IPE,2IOP,1AM1


Conserved Protein Domain Family
HATPase_Hsp90-like
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cd16927: HATPase_Hsp90-like 
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Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains
This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Links
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Statistics
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PSSM-Id: 340404
Aligned: 55 rows
Threshold Bit Score: 209.685
Created: 29-Feb-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on structures of the HATPase domain of human Hsp90, Escherichia coli DNA gyrase B, and other related proteins, bound with ATP, ADP or their analogs; contacts at 4A
  • Structure:1AM1: Saccharomyces cerevisiae Hsp90 HATPase domain binds ADP, contacts at 4A
  • Comment:in this structures of the yeast Hsp90 HATPase domain the ATP-lid is open exposing the ATP binding site
  • Citation:PMID 9230303
  • Structure:1BYQ: human Hsp90 HATPase domain binds ADP, contacts at 4A
  • Comment:in this structure of the human Hsp90 HATPase domain the ATP-lid is open exposing the ATP binding site
  • Structure:4IPE: Danio rerio mitochondrial Hsp90 (TRAP1) homodimer binds ADP, contacts at 4A
  • Citation:PMID 9817749
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #   ## ##  #                                   # # # ##     
1BYQ_A        19 AQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYETLTDPskld---sgkeLHINLIPNKqdRTLTIVDTGIGMTKADL 95  human
1AM1_A        12 TQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPkqle---tepdLFIRITPKPeqKVLEIRDSGIGMTKAEL 88  baker's yeast
YP_001086742  13 ENIFPIIKKWLYSDKDIFIRELISNGCDAVSKHKRLVSLGEisen---kssdYKITVSVNKgeGTLKFIDNGIGMTEEEI 89  Peptoclostridiu...
WP_012266721  14 ENIFPIIKKSLYTDHEIFLRELISNSVDAISKLKMASLAGEarge----vpePEINLAIDKenRTLSITDNGIGMTGEEI 89  Microcystis aer...
NP_625688     22 RGLVDLLSHHLYSSPRVYLRELLQNAVDALTARHSLEPAAPag--------sFGIRLYADG--SVVRVEDDGVGLTEADV 91  Streptomyces co...
P0C938        12 DNIFPVIKKFLYSDHEIFLREIVSNAVDATQKLKTLTSVGEfkge----tgdLRVTVSVDEvaRTITVSDRGVGMTEEEV 87  Porphyromonas g...
O33012        15 RQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKdldprtvdtsdLHIEIEVDKntRILTVRDNGIGMTRAEV 94  Mycobacterium l...
Q8RGH4        13 KELLNLMIHSIYTNKEIFLRELISNANDAIDKLKFQSLTDTdilk---dndkFRIDISVDKdnRTLTISDNGIGMTYEEV 89  Fusobacterium n...
P61184        13 KQLLDIVIHSLYSHKEIFLRELLSNASDAIDKLKFNSLTHPsllp---enwqPAIRLEPNSetKTLKIIDNGIGMTQEEV 89  Bdellovibrio ba...
P46208        11 KRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYYKALTDDaltf---dkdsYYIKVAADKdaRTLTISDTGIGMTKDEL 87  Bacillus subtil...

Feature 1          ## #######                       #######           # #                        
1BYQ_A        96 INNLGTIAKSGTKAFMEALQaga-------disMIGQFGVGFYSAYLVAEKVTVITKhn---ddEQYAWESSAGGSFTVR 165 human
1AM1_A        89 INNLGTIAKSGTKAFMEALSaga-------dvsMIGQFGVGFYSLFLVADRVQVISKsn---ddEQYIWESNAGGSFTVT 158 baker's yeast
YP_001086742  90 KKYINQVAFSGAEDFFNKYKdkme-----esndIIGHFGLGFYSAFMVSKKVQIDTLsyt-egaTPVRWISEGGTEYEIS 163 Peptoclostridiu...
WP_012266721  90 KKYINQVAFSSAEEFINKYQksa--------ndLIGHFGLGFYSAFMVAKKVEIDTLsyq-egaTPVHWSCDGSPEFELT 160 Microcystis aer...
NP_625688     92 HAFLATIGRSSKRAEQVAEQrg----------dFIGQFGIGLLSCFLVADEIHVVSRsartpdaPAVEWRGRGDGSYTVR 161 Streptomyces co...
P0C938        88 EKYINQIAFSSAEEFLEKYKddk--------aaIIGHFGLGFYSAFMVSERVDVITRsfr-edaTAVKWSCDGSPEYTLE 158 Porphyromonas g...
O33012        95 VDLIGTLAKSGTAKLRQKLHaaknlkdtaasegLIGQFGIGFYSSFMVANKVELLTRkag--etAATRWSSDGEATYTIE 172 Mycobacterium l...
Q8RGH4        90 DDNIGTIAKSGSKLFKEQLEeakk-----gdidIIGQFGVGFYSGFIVADKITLETKspy--seNGVKWISSGDGNYEIE 162 Fusobacterium n...
P61184        90 VEFIGTIARSGAKAFMQMNAemkt------kpeLIGQFGVGFYSAFMVADRVTLHTQkag--snDGTVWESMGDGTYSLD 161 Bdellovibrio ba...
P46208        88 EQHLGTIAKSGSLAFKKENElkd-------ghdIIGQFGVGFYAAFMVADVVTVISKalg--seEAYKWESAGADGYTIE 158 Bacillus subtil...

Feature 1                  ## #                                 
1BYQ_A       166 TDtgep-mgrGTKVILHLKe-----DQTEYLeerRIKEIVKKHSQFI 206 human
1AM1_A       159 LDevnerigrGTILRLFLKd-----DQLEYLeekRIKEVIKRHSEFV 200 baker's yeast
YP_001086742 164 ESdar--ndrGTTITLFIDd-----DSKEFLdefTVRGIINKYCSFL 203 Peptoclostridium difficile 630
WP_012266721 161 DSsrs---qiGTTITLTLMd-----EEGEYLepaRIRQLVKTYSDFM 199 Microcystis aeruginosa
NP_625688    162 TLrasarprpGTTVTLTPRa-----DAGEWTrpaQVWALAGHFGSLL 203 Streptomyces coelicolor A3(2)
P0C938       159 PAdka---drGTDIVMHIDe-----ENSEFLkkeKIEGLLGKYCKFL 197 Porphyromonas gingivalis W83
O33012       173 SVdea---pqGTSVTLHLKpedfedELHDYTsewKIRELVKKYSDFI 216 Mycobacterium leprae TN
Q8RGH4       163 EIakq---drGTKITLHLKdg---dEYNEFLedwKIKDLVKKYSNYI 203 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
P61184       162 SVprp--egtGTTITLHMKdfkeedEVQNFTdkwVLKSLVKKYSDFI 206 Bdellovibrio bacteriovorus HD100
P46208       159 PCekd---svGTDIILKIKenteddSYDEFLeeyRLKAIIKKYSDFI 202 Bacillus subtilis subsp. subtilis str. 168

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