4EGC


Conserved Protein Domain Family
SIX1_SD
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pfam16878: SIX1_SD 
Transcriptional regulator, SIX1, N-terminal SD domain
SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.
Links
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Statistics
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PSSM-Id: 465293
Aligned: 53 rows
Threshold Bit Score: 122.264
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EGC_A       379 FTQEQVACVCEVLQQGGNLERLGRFLW-SLPA-C-D-------HlhkNESVLK----------------AKAVVAFHRGN 432
XP_003112448   1 --mNQMEVICTSLFQTRDGERLVRFFD-QVESvYgVnsl-erfG---SEPMVV----------------AYAYALFHSNN 57 
EGT34079     116 YSIEQMEAIATSLFQARDGERLVSFFN-QLKAiYgAtal-nqiV---SEPILV----------------AYTYALYHSND 174
CAP25296      93 YNLDQMEAICTSLFQARDGERLVAFFN-QMKEmYgSnal-dhfG---SESIVV----------------AYTYALYHSND 151
XP_003112454 120 nyqfQMEAICTSLFQARDGERLVAFFN-QLKTvYgSnal-dhfG---SEAIVVgeespvkmelrvddlyAYTYALYHSND 194
O17894        97 YSMEQMEAISTSLFQARDGDRLVAFFK-QLESlYgPnav-dhlR---SEAIIV----------------AYTYALYHSNE 155 Caenorhabditis ...
5_pfamImport   1 YSLAQIETICIALFQAKDGRKLVSFFE-DLKMaNqCval-enwG---HETIIV----------------AYTYALYHSND 59 
2_pfamImport   1 YTLEQMEAICKSLFQARDGDRLVAFFK-QLEDrYgSfqldnwrF---SETVVV----------------AYTYALYHSND 60 
KRY32759      18 YTDEQLMCICETLCQAKDYPSICRLFDyLYPNeYlHs------T---HPSLMR----------------ARLLYLLMKCR 72 
XP_009012183   4 FTKEQLMCICEVLLKECKYDKLRELLV-SNEFrTyE-----------NDIFVL----------------VRIKVHLHYSE 55 

4EGC_A       433 FRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLR--GRPLGAVGKYRVRRKFPLP 488
XP_003112448  58 FTKLYNLLSTRNFDKKYFDDLTKIWYEAKYKEAQLNRksGEELTAVERHRLRKRTELP 115
EGT34079     175 FEQLFNLLATHSFQHIYFNDLQDIWHHARYRESQLKR--GKELNPVEKYRLRRKFPPP 230
CAP25296     152 FERLFHLLSTRHFHATFFADLQEIWHYARYKESQLKR--GKELNPVEKYRLRRKFPPP 207
XP_003112454 195 FERLFHLLSTRHFQQIYFTDLQEIWHYARYKESQLKR--GKELNPVEKYRLRRKFPPP 250
O17894       156 FETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKR--GKELNPVEKYRLRRKFPAP 211 Caenorhabditis elegans
5_pfamImport  60 FDTLFQLLSTRPFHQSHFKELQDIWTDAKCKESELKR--GKRLTAVERYRLRQKSTFP 115
2_pfamImport  61 FETLFQLLSSRPFHHSHFSDLQEIWHHARYKESQLKR--GKELNPVEKYRLRRKFPPP 116
KRY32759      73 FKEIYDLLSSSVFDSRYHEELQEIWWQAHYAELEQAR--CKPLGAVEKYRLRKKHPPP 128
XP_009012183  56 YDSVYHLIMNRLFNKCYHKELQMLWDEAHYRQYQTKK--GL-LMTTDKFRIRKKHPYP 110
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