5AMR


Conserved Protein Domain Family
Bunya_RdRp

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pfam04196: Bunya_RdRp 
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Bunyavirus RNA dependent RNA polymerase
The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encode on the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment.
Statistics
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PSSM-Id: 282102
Aligned: 8 rows
Threshold Bit Score: 753.153
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AMR_A  597 LDKERCQRIVSSPG----LFl----T-TCLLFKHDNpt----------lVMSDIMN---FSIYTSLSITK-SVLSLTEPA 653 
P20470  597 LDKERCQRIVSSPG----LF-----IlSSMLLYNNNpe----------vNLVDVLN---FTFYTSLSITK-SMLSLTEPS 653  Bunyamwera virus
Q8JPR2  596 LDKERCQRIVSSPG----LF-----LtTCLLFKHDNpt----------lVMSDIMN---FSIYTSLSITK-SVLSLTEPA 652  La Crosse virus L78
P23456  562 IDLNRLLALNIAFEk--aLIa----TaTWFQYYTEDqgqf-----plqyAIRSVFA---NHFLLAICQKM-KLCAIFDNL 626  Hantaan virus 76-118
Q66431 2129 VSFTKEEILVKRLEk---GFl---nKyKKEVMEAVNlify------cclTAPWCLH---YKSLEAYLVRHpEILETECIK 2193 Dugbe virus (isolat...
Q85431 1066 VNWVRCEAMMLAQR----GFw----ReFYAVAPSIEeqdgm----aepdSVCQMMS----WTLLILLNDKhQLEEMITVS 1129 Rice stripe virus (...
P33453  609 TNVVKCLSTGFNLF----WFw----RdYYEVPFWAGnek-------dfqTGKQRANkmfKFCLLMLLEDKaRTEEIATLS 673  Uukuniemi virus S23
P28976  823 LNQVRLLRLFKTPSkvpvCFpqfskKaNEIGKSLKNkdiekvnlfsmtmTVKQILInivFSSVMIGTVTKlSRMGIFDFM 902  Tomato spotted wilt...
5AMR_A  654 R-YMIMNSLAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIKDNRELT-SI 731 
P20470  654 R-YMIMNSLAISSHVRDYIAEKFSPYTKTLFSVYMVNLIKRGCASANEQSSKIQLRNIYLSDYDITQKGVNDGRNLD-SI 731  Bunyamwera virus
Q8JPR2  653 R-YMIMNSLAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIKDNRELT-SI 730  La Crosse virus L78
P23456  627 R-YLIPAVTSLYSGFPSLIEKLFERPFKSSLEVYIYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGVYP-SF 704  Hantaan virus 76-118
Q66431 2194 EnDIPLLDLTVTSLIRSLIDDIEGESSFNDSSDIKVRFAVKYLITLFTANGEPFSLSLNDGGLNDDLQLTTDEKLLY--Q 2271 Dugbe virus (isolat...
Q85431 1130 R-FVHMEGFVTFPAWPKPY-KMFDKLSVTPRSRLECLVIKRLIMLMKHYSENPIK--FMIEDEKKKWFGFKNMFLLDcNG 1205 Rice stripe virus (...
P33453  674 R-YVMMEGFVSPPCIPKPQ-KMIEKLPNLARTKFQVWLISRMLQTIIRVSDYPFK--ITAGHKSANWTGMFNWVTGE--- 746  Uukuniemi virus S23
P28976  903 R-YAGFLRLSDYSNIKEYIRDKSDPDITNCGRYLFRNGIKKLLFRMEDLNLSTNAKPVVVDHENDIIGGITNLNIKC-PI 980  Tomato spotted wilt...
5AMR_A  732 WFPGSVT-LKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILEIECEQRENIke-----iwSTNCTK--Qt---VNLKIL 800 
P20470  732 WFPGKVN-LKEYINQIYLPFYFNAKGLHEKHHVMIDLAKTVLEIEMNQRSDNlg-----iwSKAEKK--Qh---VNLPIL 800  Bunyamwera virus
Q8JPR2  731 WFPGSVT-LKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILEIECEQRENIke-----iwSTNCTK--Qt---VNLKIL 799  La Crosse virus L78
P23456  705 MSRIVYKhYRSLISEVTTCFFLFEKGLHGNMNEEAKIHLETVEWALKFREKE---------EKYGES------------- 762  Hantaan virus 76-118
Q66431 2272 TKKVFAK--LGLSGNNYDFIWTLQMIANSNFNVCKRLTGRTTG-ERLPRSVR----------SKVIY-----------EM 2327 Dugbe virus (isolat...
Q85431 1206 KLADLSD-QDQMLNLFYLG-YLKNKDEEVEDNGMGQLLTKILGFESAMPKTR----------DFLGMkdP----EYGTIK 1269 Rice stripe virus (...
P33453  747 --PIEST--QKLISLFYLG-YLKNKEESPERNASIGMYKKILEYEDKHPGRY----------TYLGLgdP----PSDDTR 807  Uukuniemi virus S23
P28976  981 TGSTLLT-LEDLYNNVYLAIYMMPKSLHNHVHNLTSLLNLPAEWELKFRKELgfnifediyPKKAMFddKdlfsINGALN 1059 Tomato spotted wilt...
5AMR_A  801 IHSLCKNLLADTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLK---IGDFRKEKELQSVKQKKILEVQS-RKMRLAN 876 
P20470  801 IHSIAKSLILDTSRHNHLRNRVESRNNFRRSITTISTFTSSKSCIK---IGDFREIKDKETEKSKKSTEKFD-KKFRLSN 876  Bunyamwera virus
Q8JPR2  800 IHSLCKNLLADTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLK---IGDFRKEKELQSVKQKKILEVQS-RKMRLAN 875  La Crosse virus L78
P23456  763 --LVENGYMMWELRANAEL--AE-QQLYCQDAIELAAIELNKVLAT-----KSSVVAN--SILSKNWEEPYF-SQTRNIS 829  Hantaan virus 76-118
Q66431 2328 VKLVGETGMAILQQLAFSQ-ALNYDHRFYAVLAPKAQLGGSRDLLVq--ETGTKVIHATTEMFSRNLLKTTS-DDGLTNP 2403 Dugbe virus (isolat...
Q85431 1270 KHEFSISYVKDLCDKFLDR--LKKTHGIKDPITYLGDKIAKFLSTQf--IETMASLKAS-SNFSEDYYLYTPsRRLKNQE 1344 Rice stripe virus (...
P33453  808 FHEYSISLLKHLCIHAEHDLRRNWGESFKAMISRDIVDAIASLDLEr-----LATLKAS-SNFNEEWYQKRG-------D 874  Uukuniemi virus S23
P28976 1060 VKALSDYYLGNIENVGLMRSEIENKEDFLSPCYKISTLKSSKKCSQsniISTDEIIECLQDAKIQDIENWKG-NNLAIIK 1138 Tomato spotted wilt...
5AMR_A  877 ---PMFVTDEQVCLEVGHCN-------YEMLRNAMPny-----------------tdYISTKVFDRLYELLDKKVLTDKP 929 
P20470  877 ---PLFLEDEEANLEVQHCN-------YRALIQKIPny-----------------kdYISVKVFDRLYELLKNGVLTDKP 929  Bunyamwera virus
Q8JPR2  876 ---PMFVTDEQVCLEVGHCN-------YEMLRNAMPny-----------------tdYISTKVFDRLYELLDKGVLTDKP 928  La Crosse virus L78
P23456  830 --------LKGMSGQVQEDG--------H-LSSSVT---------------------IIEAIRYLSNSRHNPS-LLKLYE 870  Hantaan virus 76-118
Q66431 2404 -------HLKETRLNIGLDM--------LSTARALD---------------------GKQVSDDSNLLNFFKTVCISGDN 2447 Dugbe virus (isolat...
Q85431 1345 qsrSKHVIDAGGNISASVKGk------LYHRSKVIE---------------------KLTTLIKDETPGKELKIVVDLLP 1397 Rice stripe virus (...
P33453  875 ----------------G-KT--------YHRSKVLE--------------------------KVSKYVKKSSSHVHHIME 903  Uukuniemi virus S23
P28976 1139 gliRTYNEEKNRLVEFFEDNcvnslylIEKLKEIISsgsitvgksvtskfirnnhplTVETYLKTKLYYRNNVTVLKSKK 1218 Tomato spotted wilt...
5AMR_A  930 VIEQIMDMMidH-----KKFYFT-FFNKGQKTSK--DREIFVGEYEAKMCMYA-VERIAKERCKLNPDEMISEPGDGKLK 1000
P20470  930 FIELAMEMM--Kn---hKEFSFT-FFNKGQKTAK--DREIFVGEFEAKMCMYV-VERISKERCKLNTDEMISEPGDSKLK 1000 Bunyamwera virus
Q8JPR2  929 VIEQIMDMM--Vd---hKKFYFT-FFNKGQKTSK--DREIFVGEYEAKMCMYA-VERIAKERCKLNPDEMISEPGDGKLK 999  La Crosse virus L78
P23456  871 ETREQKAMA--R---------IV---RKYQRTEA--DRGFFITTLPTRCRLEI-IEDYYDAIAKNISEEYISYGGEKKIL 933  Hantaan virus 76-118
Q66431 2448 TKWGPIHCC--S-----FFSGMMqQLLKDVQDWSsfYKLTFIKNLCRQIEIPApSIRKILNVLRFKLSDKGGVEKLSEEA 2520 Dugbe virus (isolat...
Q85431 1398 KAMEVLNKN--E--------CMHiCIFKKNQHGG--LREIYVLNIFERIMQKT-VEDFSRAILECCPSETMTSPKNK--F 1462 Rice stripe virus (...
P33453  904 ECLRKVESQ--G--------CMHvCLFKKPQHGG--LREIYVLGFEERVVQLV-IETIARQICKRFKSETLTNPKQK--L 968  Uukuniemi virus S23
P28976 1219 VSEELYDLV--KqfhdmMEIDLDsVMNLGKGTEG--KKLTFLQMLEFVMSKAK-NVTGSVDFLVSVFEKMQRTKTDREIY 1293 Tomato spotted wilt...
5AMR_A 1001 VLEQKSEQEIrFLVETTRQKNREIDEaiealategyes----------nlgkieklslgKaKGLKMEINADMSKWSAQDV 1070
P20470 1001 ILEKKAEEEIrYIVERTKDSIIKGDP---------------------------------S-KALKLEINADMSKWSAQDV 1046 Bunyamwera virus
Q8JPR2 1000 VLEQKSEQEIrFLVETTRQKNREIDEaiealaaegyes----------nlekieklslgKaKGLKMEINADMSKWSAQDV 1069 La Crosse virus L78
P23456  934 AIQGALEKALrWASGESFIELSNHKFir--------------------------------mKRKLMYVSADATKWSPGDN 981  Hantaan virus 76-118
Q66431 2521 IRSELINNLAeWEGNDTVKFLITTYIsk-----------------------------giMaMNSYNHMGQGIHHATSSLL 2571 Dugbe virus (isolat...
Q85431 1463 RIPELHNMEArKTLKNEYMTISTSDDas--------------------------------kWNQGHYVSKFMCMLLRLTP 1510 Rice stripe virus (...
P33453  969 AIPETHGLRAvKTCGIHHETVATSDDaa--------------------------------kWNQCHHVTKFALMLCHFTD 1016 Uukuniemi virus S23
P28976 1294 LMSMKVKMML-YFIEHTFKHVAQSDPseaisisgdnkiralstlsldtitsyndilnknSkKSRLAFLSADQSKWSASGL 1372 Tomato spotted wilt...
5AMR_A 1071 F--YKYFWLIALDPILYPQEKERILYFMCNY-MDKELILPDELLFNLLDQKVAYQN--DIIATMTNQLNSNTVLIKRNWL 1145
P20470 1047 F--YKYFWLIAMDPILYPAEKTRILYFMCNY-MQKLLILPDDLIANILDQKRPYND--DLILEMTNGLNYNYVQIKRNWL 1121 Bunyamwera virus
Q8JPR2 1070 F--YKYFWLIALDPILYPQEKERILYFMCNY-MDKELILPDELLFNLLDQKVAYQN--DIIATMTNQLNSNTVLIKRNWL 1144 La Crosse virus L78
P23456  982 SakFRRFTSMLHNGLPNNKLKNCVIDALKQV--YKTDFFMSRKLRNYIDSMESLDP--HIKQFLDFFPDGHHGEVKGNWL 1057 Hantaan virus 76-118
Q66431 2572 T--SMMAETFEELAVDYMKKHFPGLTVNVDHaGSSDDYAKCIIVSGLVSKDMYKRY--DGVFWRHMCRLKNFLAAVRRCC 2647 Dugbe virus (isolat...
Q85431 1511 T--YYHGFLVQALQLWHHKKIFLGDQLLQLFn-QNAMLNTMDTTLMKVFQAYKGEI--QVP-WMKAGRS--YIETETGMM 1582 Rice stripe virus (...
P33453 1017 P--LFHGFIIRGCSMFMKKRIMIDQSLIDIId-SHTTLETSDAYLQKIHRGYHGSLd-DQPRWISRGGA--FVQTETGMM 1090 Uukuniemi virus S23
P28976 1373 Tt-YKYVLAIILNPILTTGEASLMIECILMYvKLKKVCIPTDIFLNLRKAQQTFGEneTAIGLLTKGLTTNTYPVSMNWL 1451 Tomato spotted wilt...
5AMR_A 1146 QGNFNYTSSYVHSCAMSVYKEILk----EAITLLDg------sILVNSLVHSDDNQTSITI---VQDKMENDKII----- 1207
P20470 1122 QGNFNYISSYVHSCAMLVYKDILk----ECMKLLDg------dCLINSMVHSDDNQTSLAI---IQNKVSDQIVI----- 1183 Bunyamwera virus
Q8JPR2 1145 QGNFNYTSSYVHSCAMSVYKEILk----EAITLLDg------sILVNSLVHSDDNQTSITI---VQDKMENDKII----- 1206 La Crosse virus L78
P23456 1058 QGNLNKCSSLFGVAMSLLFKQVWt----NLFPELD--------CFFEFAHHSDDALFIYGYlepVDDGTDWFLFVsqqiq 1125 Hantaan virus 76-118
Q66431 2648 Q-MKDSAKTLVGDCFLEFYSEFMmg--nRVTPAVIk------fIFTGLINSSVTSPQSLVQachVSSQQGMYNSVp---- 2714 Dugbe virus (isolat...
Q85431 1583 QGILHYTSSLFHAIFLDQLAEECrrdinRAIKTINnkenekvsCIVNNMESSDDSSFIISIpnfKENEAAQLYLL----- 1657 Rice stripe virus (...
P33453 1091 QGILHYTSSLLHTLLQEWLRTFSqr-fiRTRVSVDqr----pdVLVDVLQSSDDSGMMISFp--STDKGATGKYR----- 1158 Uukuniemi virus S23
P28976 1452 QGNLNYLSSVYHSCAMKAYHNTL-----ECYKNCD--------FQTRWIVHSDDNATSLIAsgeVDKMLTDFSSS----- 1513 Tomato spotted wilt...
5AMR_A 1208 -----------DFAMKEFERACLTFG--CQ--ANMKKTYVTN-CIKEFVSLFN--LYGEPFSI-YGRFLLTSVGDCAYIG 1268
P20470 1184 -----------QYAANTFESVCLTFG--CQ--ANMKKTYITH-TCKEFVSLFN--LHGEPLSV-FGRFLLPSVGDCAYIG 1244 Bunyamwera virus
Q8JPR2 1207 -----------DFAMKEFERACLTFG--CQ--ANMKKTYVTN-CIKEFVSLFN--LYGEPFSI-YGRFLLTSVGDCAYIG 1267 La Crosse virus L78
P23456 1126 aghlhwfsvntEMWKSMFNLHEHILLlgSIk-ISPKKTTVSP-TNAEFLSTF---FEGCAVSIpFVKILLGSLSDLPGLG 1200 Hantaan virus 76-118
Q66431 2715 -----------LVTNAAFTILRQQIFynHVedFIRRYGLITLgAVSPFGRLFLprFSGLVSSS-VALEDSETISKAAAEI 2782 Dugbe virus (isolat...
Q85431 1658 -----------CVVNSWFRKKEKLGTylGIy-KSPKSTTQTL-FVMEFNSEFF--FSGDVHRP-TFRWVNAAVLIGEQET 1721 Rice stripe virus (...
P33453 1159 -----------YLSALIFKYKKVIGKylGIy-SSVKSTNNTL-HLLEFNSEFF--FHINHNRP-LLRWITACDTISEQES 1222 Uukuniemi virus S23
P28976 1514 -----------SLPEMLFRSIEAHFKsfCIt-LNPKKSYASS-SEVEFISERI--SKWSDYSS-LLQAFSKLLHRIFAYK 1577 Tomato spotted wilt...
5AMR_A 1269 PYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYN-MLPGQSNDPIDYFPAENR----KDIPIELNGVLDAPLS 1343
P20470 1245 PYEDLASRLSAAQQSLKHGCPPSLVWLAISCSHWITFFTYN-MLDDQINAPQQHLPFNNR----KEIPVELNGYLNAPLY 1319 Bunyamwera virus
Q8JPR2 1268 PYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYN-MLPGQSNDPIDYFPAENR----KDIPIELNGVLDAPLS 1342 La Crosse virus L78
P23456 1201 YFDDLAAAQSRCVKALDLGASPQVAQLAVALCTSKVERLYG-TAPGMVNHPAAYLQVKHT-----DTPIPLGGNGAMSIM 1274 Hantaan virus 76-118
Q66431 2783 NSNDIFFNTSSLSNLDKLEQSPDSSGLDDDSVVSTTTVESS-DSKGSSSSFTFDLNRPLSe---TEVKFLKLLRELTSTT 2858 Dugbe virus (isolat...
Q85431 1722 LSGIQEELSNTLKDVIEGGGTYALTFIVQVAQAMIHYRMLGsSASSVWPAYETLLKNSYD-------PALGFFLMDNPKC 1794 Rice stripe virus (...
P33453 1223 LASRQEEMYNNLTSVLEGGGSFSLVSFCQFGQLLLHYTLLGmTVSPLFLEYIKLVSEIKD-------PSLGYFLMDHPFG 1295 Uukuniemi virus S23
P28976 1578 LFDDLMSLSIHVTMLLRKGCPNEVIPFAYGAVQVQALSIYS-MLPGEVNDSIRIFNKLGVslksNEIPTNMGGWLTSPIE 1656 Tomato spotted wilt...
5AMR_A 1344 MISTVGLESGN 1354
P20470 1320 LIALVGLEAGN 1330 Bunyamwera virus
Q8JPR2 1343 MISTVGLESGN 1353 La Crosse virus L78
P23456 1275 ELATAGIGMSD 1285 Hantaan virus 76-118
Q66431 2859 ACEMLQEKINT 2869 Dugbe virus (isolate ArD44313)
Q85431 1795 AG-LLGFNYNV 1804 Rice stripe virus (isolate T)
P33453 1296 SG-LSGFKYNV 1305 Uukuniemi virus S23
P28976 1657 PLSILGPSSND 1667 Tomato spotted wilt virus (strain Brazilian BR-01)
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