2C9W,1HV2,1VCB,2FNJ,4B9K,4JGH


Conserved Protein Domain Family
BTB_POZ_EloC

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cd18321: BTB_POZ_EloC 
Click on image for an interactive view with Cn3D
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.
Statistics
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PSSM-Id: 349630
Aligned: 50 rows
Threshold Bit Score: 105.748
Created: 16-Oct-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:elongin B interface [polypeptide binding site]
Evidence:
  • Comment:Elongin regulatory subunits B and C form a complex (BC) that functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes
  • Structure:2C9W: Homo sapiens elongin-C in complex with elongin-B; contacts at 4A
  • Structure:1VCB: Homo sapiens elongin-C in complex with elongin-B; contacts at 4A
  • Structure:4JGH: Mus musculus elongin-C in complex with elongin-B; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #      ########                                   ###  #  ##  ##  ##          ##
2C9W_C         3 YVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFaen--etNEVNFREiPSHVLSKVCMYFTYKVRYTNSs---tEIPE 77  human
1HV2_A         5 FVTLVSKDDKEYEISRSAAMISPTLKAMIEGPFREs-----kGRIELKQfDSHILEKAVEYLNYNLKYSGVsedddEIPE 79  Saccharomyces c...
XP_003082270  11 PITLVSREGVEFTVTLGALRVSGVLSRLFASADARdfeeqrtRTVRLRDvSTAIVRKIVEYCEYRQTYEGSn---kAPPP 87  Ostreococcus tauri
CBQ70381      13 WVTLVSEDGYRFLVDNTTVMASPTIKTMLSTGEGGgfaeaesNTARLQI-RGEVLEKVIEYLHFKTKYGAAadmdvPDFK 91  Sporisorium rei...
CCJ30536       7 FLKLISSDGFIFLIKRSQACISGTIREMLNESNNFlen--knNEINFKTiNAKLLDIVCQYLYFHEKYKNAe----CVPE 80  Pneumocystis ji...
ELQ76938       4 IVTLISSDNKKYEIPEHIANESKTLRVFFDSNRPFiea--ieRKVVLPM-NSKLLIRAIEYMKYKYQYRGKka--hEAPE 78  Trachipleistoph...
XP_005702814  19 YVLLKSSDGFEFYVAEECAKVSKFLKTTLESDFSEak----tGQMILNEiPGHLLEKVCEYFYYHIMYEQTe---gNLPP 91  Galdieria sulph...
KUI53278       6 YITLVSADGFEYVLPREACYASPMLKRTINPDGGFmes--rtGVVRMEDmSAVILEKVVEYLLYWYRYQDKe----DVPD 79  Valsa mali var....
OHT06201      29 ALTLVSNDGYEFVIDKQTAMISLTIRNMLYGGANFees--etKIIRLPI-RAIILERIIEYWHYRSQYSDHl---dQLPK 102 Tritrichomonas ...
Q751F9         6 HVTLVSSDGKSFEVPRERAMLSPTLAKMLDSSFAEak----eAKVTLPTiESSMLAKVVEYLEYLEEYKHKdd-geDIPQ 80  Ashbya gossypii...
Feature 1        #   ### ##          
2C9W_C        78 FPIAPEIALELLMAANFLDC 97  human
1HV2_A        80 FEIPTEMSLELLLAADYLSI 99  Saccharomyces cerevisiae S288c
XP_003082270  88 FEIAGEDAIELLMTANFLDV 107 Ostreococcus tauri
CBQ70381      92 NRIPPEIALELLMAADFLEL 111 Sporisorium reilianum SRZ2
CCJ30536      81 FPIEPDTAIELLMISDFLDG 100 Pneumocystis jirovecii
ELQ76938      79 FHITDEEALDLLDASVYLKI 98  Trachipleistophora hominis
XP_005702814  92 FEFPPEMAVELLMVANFLDT 111 Galdieria sulphuraria
KUI53278      80 MEIPVDMCLELLTAADYLQL 99  Valsa mali var. pyri
OHT06201     103 FDIDPKMAIELLQGAEYLQT 122 Tritrichomonas foetus
Q751F9        81 FEVPPEISLELLLAADYLQI 100 Ashbya gossypii ATCC 10895

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