1P0R,3PLU,4PYU,1M94,1UH6


Conserved Protein Domain Family
Ubl_UBL5

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cd01791: Ubl_UBL5 
Click on image for an interactive view with Cn3D
ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins
UBL5, known as Hub1 in yeast, is an atypical ubiquitin-like (Ubl) post-translational modifier that contains a conserved Ubl domain with a beta-grasp Ubl fold. At the C-terminal end of its Ubl fold is a di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other Ubl modifiers, and thus UBL5 does not form covalent conjugates with cellular proteins. The yeast Hub1p binds non-covalently to the HIND element of spliceosomal protein Snu66p (Snu66p is termed SART1 in mammals) and modifies the spliceosome by this unconventional Ubl modifier. In higher eukaryotes, UBL5/Hub1 plays a role in modulating pre-mRNA splicing. It also is required for signaling in the mitochondrial unfolded protein response, through interaction with the transcription factor DVE-1 and upregulation of chaperone genes in response to mitochondrial stress. Moreover, UBL5 functions as a factor that directly binds to and stabilizes FANCI, and promotes the functionality of the Fanconi anemia (FA) DNA repair pathway.
Statistics
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PSSM-Id: 340489
Aligned: 45 rows
Threshold Bit Score: 114.338
Created: 9-Jun-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:HIND interaction site [polypeptide binding site]
Evidence:
  • Comment:Ubl-HIND element interaction site
  • Comment:Hub1 binds non-covalently to a spliceosomal protein Snu66p HIND element
  • Structure:3PLU; Saccharomyces cerevisiae Ubl domain of Hub1p interacts with HIND element, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #             # ###  #   #  ##  ##                                     
1P0R_A        21 MIEVVCNDRlGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHvslgdyEIHDGMNLELY 91  human
3PLU_A        21 MIEVVVNDRlGKKVRVKCLGEDSVGDFKKVLSLQIGTQPNKIVLQKGGSVLKDHisledyEVHDQTNLELY 91  baker's yeast
XP_005705263   1 MIEVICNDRlGRKIRVKCNPDDTIGDLKKLIAAQTGTRPEKIRIQKWYTVYKDHisladyEIHDGMGLELY 71  Galdieria sulphuraria
XP_002773563   1 MIEVVCNDRlGKKIRVKCNPDDTIGDLKKLLAAQIGTRPEKIRIQKWYNVYKDHitladyEIHDGMGLELY 71  Perkinsus marinus ATCC 5...
KDD76987       1 MIEVVLNDRlGKKIRVKCNEDDTVGDLKLLVAAQTGTRPEKIRIQKWHNVFKDHitladyEIHDGMSLELY 71  Helicosporidium sp. ATCC...
CDI78983       1 MIEVILNDRlGRKIRVKCNPDDTVGDLKKLVAAQCGTRPDKIRIQKWYTVYKDHitledyEIHDGMGLELY 71  Eimeria acervulina
XP_004335785 176 MIEITLNDRlGKKVRVKACSNDTVGQLKKMVAAQTGTKAEKIRIQKWYTIYKDNisladyEVRDGMNLELY 246 Acanthamoeba castellanii...
EJY72701     148 MMEVIVNDRlGQKVRIKCMPDDTIFNLKQLISGHTGIRAEKIRLQKQHQIYKDQitledyEVKEGMMLEMY 218 Oxytricha trifallax
XP_648708      7 MIEVILNDRlGKKFRVKVHEDDTVMDLKIVAGAKTGTRPDKIKIQRGNNVYQDHislesyEVVDGMSLEMY 77  Entamoeba histolytica HM...
CEF99305       1 MIEITLNDRlGKKIRVKCNEDDTIGDLKKLVAAQTGTRAEKIRIQKWYTIYKDHitledyEVHDGANLELY 71  Ostreococcus tauri

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