4DWN


Conserved Protein Domain Family
CARD_BinCARD_like
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cd13785: CARD_BinCARD_like 
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BinCARD (Bcl10-interacting protein with CARD)
BinCARD was ubiquitously expressed CRAD (Caspase activation and recruitment domain) protein in all tissues. CARD proteins play important role in apoptosis by functioning as direct regulators of death-inducing caspases. BinCARD interacts with apoptosis inducer CARD protein Bcl10 through CARD. It inhibits Bcl10-mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation. Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. In general, DDs domains are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Links
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Statistics
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PSSM-Id: 260079
Aligned: 6 rows
Threshold Bit Score: 146.461
Created: 14-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative Bcl10
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Bcl10 interaction site [polypeptide binding site]
Evidence:
  • Comment:These residues on the helix 2-3 surface of BinCARD form an acidic patch; it has been suggested that the helix 2-3 surface may interact with a complementary surface on Bcl10.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #   #                   #                                        
4DWN_A        11 LVQDTPFLTghgrlsEQQVDRIILQLNRYYPQILTNKEAEKFRNPkaslrVRLXDLLSHLQrSGERDCQEFYRALYIHaq 90  human
EMC84000       7 LQHDMYFLTsnsrlnEQVVDKIILQLNRVYPQILTNAEAEKFRNPkaslhTRLADLLKHLQkKGDRHCQEFYRALQINae 86  domestic pigeon
XP_002941782  10 LLQDTPYLTrigrlsERVTDRIILQLNRVYPQILSNKEAERFRNPqtplrTRLSDLLTHLHrKGDRECQEFYRALRNNad 89  western clawed ...
ACI68861       9 LLEDSRFLRtdrrldTELVDKLILQLNRIYPQILTDKEATKFRDLdvptcVRLAELLAHLQgKGEEACREFYRALHLHve 88  Atlantic salmon
XP_004070832  10 LQNDAPFLCsdqrmdAALVDRLVLQLNRVYPQILSDKEAGKFRSLsvptkVQLHQLLKHLCeKGEESCLEFYGALHIHae 89  Japanese medaka
Q96LW7        10 LVQDTPFLTghgrlsEQQVDRIILQLNRYYPQILTNKEAEKFRNPkaslrVRLCDLLSHLQrSGERDCQEFYRALYIHaq 89  human

Feature 1              
4DWN_A        91 PLHSRL 96  human
EMC84000      87 QLYNDL 92  domestic pigeon
XP_002941782  90 KVYATL 95  western clawed frog
ACI68861      89 EVYFSL 94  Atlantic salmon
XP_004070832  90 DIYRDL 95  Japanese medaka
Q96LW7        90 PLHSRL 95  human

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