6S1Y,5AMB


Conserved Protein Domain Family
Peptidase_M2

?
pfam01401: Peptidase_M2 
Angiotensin-converting enzyme
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
Statistics
?
PSSM-Id: 460196
Aligned: 54 rows
Threshold Bit Score: 765.973
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6S1Y_A                   9 APSETEISQIVEWIEQRYQQTKAHQTLAAWEYGSNLTEFNLSKKTKAAADFAEVAKAVAEELQQFKTDQLT-NATLKRRI 87   Afri...
PDM63802               307 VKDESEAREWMKGYAEEARKMLHLVTKSGWMYFTDASPTLNRALNEAEEVMARFVRATAQQAKQFDTSAFA-DEALKKQF 385 
Q2WG88                  19 STTEDLAKTFLEKFNYEAEELSYQNSLASWNYNTNITDENIQKMNIAGAKWSAFYEEESQHAKTYPLEEIQ-DPIIKRQL 97   dome...
PRJNA194094:J421_0092   42 TPTAAAARLFVDSVERRLDALSVTVNQAEWVAATYITDDTEALSADAQQRYDAAAQRFALAARRFD--GVTvPPDLRRKL 119 
ASGPB:GKIL_2224         33 VQSVAEAQKFMQRAEGELAELNVKANRASWVGATYITDDTEALSADAQTNLNSAIQRFAIEAKRFD--NLQmPPELARKF 110 
BAK67040                32 APDSAQADAFVAAAEKEAFDYSVDASRIMWVNATHITDDTDALAAQAGAKGTEMAVRFALEAAKYEQVPGL-SFDTKRKL 110 
WP_012048875            42 APTTAEADAFVADAEKQLADLGIYGAQVAWINATYITDDTDAVNARVGAEFTEMQVRYASGAARFDGLKGL-SYDTRRKL 120  Rhiz...
WP_015456931            30 APTAADADRFVAAAEKELFDLSIPTAQVAWVNATYITDDTDALNTLFGAKNTEASVRLAKEAARYDKVAGF-SFDTRRKL 108  Sphi...
Q8EE93                  43 TPDKAQAIAFIQDAEAQMAQLSIEANRAEWIYSNFITEDTAALSAAVGEKVSAASVKFATEAAKYA--NVElDPANARKL 120  Shew...
WP_013051597            36 SSKTSEAKQFLIQSEQTLSDLSIEINRAEWIYSNFITDDTAALSASAAEKLTATSVRLATQAAQYT--DLAlDDTSLRKL 113  Shew...
6S1Y_A                  88 KKLAKLGYA-ALPAD-QFKELLGAIASMESNYAKAKFCA------YGDA---TKCdLSLDPELTEIFAN-HREPEELKYY 155  Afri...
PDM63802               386 GYVTFEGMS-TLNVA-DAEAFSTANSNMNKMAADVTVCD------LDLP---PPC-ALKKIDLESIART-DKDANRLGHL 452 
Q2WG88                  98 RALQQSGSS-VLSAD-KRERLNTILNAMSTIYSTGKACN------PNNP---QEC-LLLEPGLDDIMEN-SKDYNERLWA 164  dome...
PRJNA194094:J421_0092  120 TLLKLAFTApPPSDPaKGAELVRLTTGMEGAYGRGTYCRrgalgqPAATtgdSTC-YQIN-DLSRALAE-SHDPAVLLDA 196 
ASGPB:GKIL_2224        111 KLLKLNLIApPPSDSkEQQELTRLTVGMESEYGKGTYCR-------SPVdgkQEC-LQLN-DLERILRT-SRDPKELLDV 180 
BAK67040               111 DIMRSGIVLpAPTKPgAAAELNEIATRLQSTYGKGRGTL------DGKE-------LTGS-DIEAEMANlSHTPAQFSEM 176 
WP_012048875           121 DILKQSIVLpAPATPgAAKELNDLATRLQSAYGKGKGTL------RGEE-------INGS-DIEAAMGT-NRNPAELKEM 185  Rhiz...
WP_015456931           109 DILRQGIVLpAPATEgAATELNALSTRMSSTYGKGRGTL------AGKE-------INGS-DIEEKMGT-VRNPDQLKEM 173  Sphi...
Q8EE93                 121 NILRSALVLpAPLDPaKNAELAQISSELNGLYGKGKYCF---------Ad--GKC-MTQP-ELSSLMAE-SRDPAKLLEA 186  Shew...
WP_013051597           114 NILRSSLVLpAPLDPeKNAELAGISAQLNGLYGKGKYCF---------Dd--GRC-LTQP-ELSAIMAE-SSDPKLLLEV 179  Shew...
6S1Y_A                 156 WVQWYNATGAPVRESFQKYVELNRQAALRNNFSSGAAVWLNEYD----------DSTFEQQVDDVIEQIRPLYEQLHAYV 225  Afri...
PDM63802               453 YTTFNQNVAA-LKGNYQKIIELTNKGAKMNGFGSGSSMWLSSFDlstk--dtppQFDVMKKLNEVFKQVSPFYKQLHAYM 529 
Q2WG88                 165 WEGWRSEVGKQLRPLYEEYVALKNEMARANNYEDYGDYWRGDYEeewadgysysRNQLIEDVEHTFTQIKPLYEHLHAYV 244  dome...
PRJNA194094:J421_0092  197 WRGWHA-IGAPLRPKYERFVALSNEGARELGFADLGAMWRANYDm--------pADQFPREVERLWKQVEPLYVALHAYV 267 
ASGPB:GKIL_2224        181 WQGWHQ-IARPLRPRYERFVQLSNKGARELGFADTGAMWRSNYDm--------sPAQFSAEVERLWQQVRPLYLSLHAYV 251 
BAK67040               177 WTSWHDRVGAPMKADYVRLVDIANEGAKELGFADAGAMWRSGYDm--------pPDEFAALTEALWQEVKPLYDALHCYT 248 
WP_012048875           186 WVSWHDNVGRPMRGDYAKLVEIANKGAVDLGYKDLGAMWRAGYDm--------pADDFAKMMDRLWTQVKPLYDALHCYT 257  Rhiz...
WP_015456931           174 WASWHDNVGKPMKADYARMVEIANQGAKELGYKDLGAMWRSNYDm--------sPDEFARLTDKLWLQVKPLYDQLHCYT 245  Sphi...
Q8EE93                 187 WKGWRE-IAKPMRPLFQREVELANEGAKDLGYANLSELWRSQYDm--------kPDEFSQELDRLWSQVKPLYESLHCYV 257  Shew...
WP_013051597           180 WQGWRE-IAKPMRPLFQREVELANEGAKDLGYADLSVLWRSQYDm--------kPDEFSNELDRLWGQVKPLYDSLHCYV 250  Shew...
6S1Y_A                 226 RYKLRQKYG-DKLVSPTGPIPMHLLGNLWAQTWDNIADFTTPFPE-KK--LLDVTDEMIRQ------------------- 282  Afri...
PDM63802               530 RRQIAGLYKnPEGLTKDLAIPAHLFGTLEGGDWSAHYLDTRPYDD-EDsvPEEILAAFHGQ------------------- 589 
Q2WG88                 245 RAKLMDAY--PSRISPTGCLPAHLLGDMWGRFWTNLYPLMVPFRQ-KP--NIDVTDAMVNQ------------------- 300  dome...
PRJNA194094:J421_0092  268 RTRLNQQYG-DAVVAKDGMIPAHLLGNMWAQEWGNVYPIVAPPNA-SP--TYDLTALLKAK------------------- 324 
ASGPB:GKIL_2224        252 RTKLGEQYG-TQLVPADGPIPAHLLGNMWAQEWGNIYPLAAPAND-QR--GYDLTQLLTAK------------------- 308 
BAK67040               249 RTKLNEKYG-DAVQSPTGPIRADLLGNMWAQEWGNIYPIVAPAGTgDL--GYDIGDLLRAKgfvqttpqtidtpdtpetq 325 
WP_012048875           258 RTKLNEKYG-DAVQAKTGPIRADLLGNMWAQEWGNIYDIVAPKGAgDL--GFDIGDLLVAK------------------- 315  Rhiz...
WP_015456931           246 RTKLNEKYG-DGVQPRTGPIRADLLGNMWAQEWGNIYDVVAPAGAgDL--GYDTTDLLKAK------------------- 303  Sphi...
Q8EE93                 258 RGELNKEYG-DAIAPKTGPIPAHLLGNMWAQQWGNVYDLVAPENA-DP--GYDVTELLAQK------------------- 314  Shew...
WP_013051597           251 RGELNEEYG-DEVVPANGPIPAHLLGNMWAQSWGNVYDKVSPQDA-DP--GYDLTQLLAEH------------------- 307  Shew...
6S1Y_A                 283 --GYTPIKMFQMGDDFFTSLNMTKLPQTFWDKSILEKPTDGRDLVCHA-SAWDFFAIDDVRIKQCTRVNMREFFVVHHEL 359  Afri...
PDM63802               590 --NITQKEMFVKAYRYFKAVGFPKLPKSFWTNSVFARVWS-KDMICNPpAAIDMRDGEEFRVKMCAQLGDTDFKQAHSLL 666 
Q2WG88                 301 --SWDARRIFEEAETFFVSVGLPNMTEGFWQNSMLTEPGDNRKVVCHP-TAWDL-GKRDFRIKMCTKVTMDDFLTAHHEM 376  dome...
PRJNA194094:J421_0092  325 --NVDAKGMAKYAEGFFTSMGFAPLPATFWERSMLVKPRD-REVVCHA-SAWTIDNKNDVRIKACLEPTADDFVTIHHEE 400 
ASGPB:GKIL_2224        309 --KVDEREMFRYGERFFTSLGFAPLPKTFWERSMLTKPRD-RDVVCHA-SAWDIDNLDDVRIKMCAEVTDSDFVTIHHEL 384 
BAK67040               326 rrGYWEKQMFRIGEGFYSSLGFDPLPETFWQRTQFIAPRD-REVVCHA-SAWDVDNRNDIRVKMCTKVNSDDFVTIHHEL 403 
WP_012048875           316 --QYDPVKMVKAGEGFYTSLGFDKLPDSFWTRSQITKPRD-REVVCHA-SAWDIDNVDDLRIKMCTKVNSDDFVTIHHEL 391  Rhiz...
WP_015456931           304 --GYDALKMVKGGENFFSSLGFAPLPDSFWQHSQFTKPAD-REVICHA-SAWDVDNKDDLRIKMCIKVNGDDFTTIHHEL 379  Sphi...
Q8EE93                 315 --GYDEHRMVKQAESFFTSLGFAPLPDSFWSRSLFLQPKD-RDVVCHA-SAWDLDNLDDIRIKMCIQKTAEDFTVIHHEL 390  Shew...
WP_013051597           308 --DYDEVKMVKQAESFFSSLGFDELPDSFWERSLFVQPKD-RDVVCHA-SAWDLDNLDDIRIKMCIQKTAEDFTVIHHEL 383  Shew...
6S1Y_A                 360 GHIQYYLQYQHQPVEFRGGANPGFHEAVGDVLSLSVSTPKHLKKVGLL--KDYEEDEQVKINQFYRAGVTKLVFLPFAYT 437  Afri...
PDM63802               667 AQTFYQFLYRKQPFSFREAANPSFNEAIANVFSILSSNTDYLFSQSLIapDSLVPKESQVINRLYKEALTHFVKLPFDLA 746 
Q2WG88                 377 GHIQYDMAYAEQPFLLRNGANEGFHEAVGEIMSLSAATPNHLKNIGLLp-PDFSEDSETDINFLLKQALTIVGTLPFTYM 455  dome...
PRJNA194094:J421_0092  401 GHNFYQRAYSSQPYLFQNGANDGFHEAIGDAIALSI-TPGYLQQAGLL---ATPPSAAADTALLLRQALDKVAFLPFGLM 476 
ASGPB:GKIL_2224        385 GHNFYQRAYKTQPPLFQNSANDGFHEAVGDTIALSV-TPDYLVKVGLL---GKAPGPESDTGFLLKQALDKVAFLPFGLL 460 
BAK67040               404 GHNYYQRAYQKHGYLYLNGANDGFHEAIGDFIALSI-TPQYLVQIGLLd-PAKVPSADKDIGLLLRQAMDKVAFLPFGLL 481 
WP_012048875           392 GHNFYQRAYNKQPYLYLNGANDGFHEAIGDFIALSV-TPDYLVRIGLLd-PAKVPSADKDIGLLLRQAMDKVAFLPFGLL 469  Rhiz...
WP_015456931           380 GHNYYQRAYNKQPYLYLNGANDGFHEAIGDAIALSI-TPDYLVRIGLLd-PAKVPPADKDIGLLLRQAMDKVAFLPFGLL 457  Sphi...
Q8EE93                 391 GHNFYQRAYKQQPFLFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---EEVPDASKDIGLLLKQALDKIAFLPFGLM 466  Shew...
WP_013051597           384 GHNYYQRAYKNQPFIFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---DEVPDASKDIGLLLKQALDKVAFMPFGLM 459  Shew...
6S1Y_A                 438 LDKYRWGVFRGDIKPREYNCKFWEMRSRYSGVEPPVV-RTEQDFDPPAKYHVSA-DVEYLRYFVSYVIQFQFHRAACALA 515  Afri...
PDM63802               747 ADEWRIEYFNGKTVPSKLNERWWQLRERYEGVRHVSPtVNASTLDALINTAIVQeHSPATRQMITYVMQFQILKALCPEG 826 
Q2WG88                 456 LEKWRWMVFKGEIPKEQWMQKWWEMKRDIVGVVEPLP-HDETYCDPAALFHVAN-DYSFIRYYTRTIYQFQFQEALCQIA 533  dome...
PRJNA194094:J421_0092  477 IDQWRWGVFSGAIKPSEYNKAWWDLRARYQGVVPPVA-RSEADFDPGAKYHVPA-NTPYMRYFLARVLQFQFYRAMCRAA 554 
ASGPB:GKIL_2224        461 IDQWRWKVFSGETQPKDYNKSWWELRERYQGIAPPLA-RSEADFDPAAKYHVAA-NTPYIRYFLARILQFQFHRALCREA 538 
BAK67040               482 IDRWRWGVFDGSIRPADYNKAWTDMRLRYQGIVPPTD-RPADSFDPGAKFHVPG-NTPYTRYFLARILQFQFYEAACRQA 559 
WP_012048875           470 MDKWRWGVFSGQISPASYNKAWTDLRLQYQGIVPPEA-RDEGDFDPGAKYHIPG-NTPYARYFLARILQFQFYKAACEQA 547  Rhiz...
WP_015456931           458 VDKWRWGVFDGSIAPQDYNKAWTALRLQYQGITPPVE-RGADAFDPGAKYHVPA-STPYTRYFLARILQFQFYKAACDQA 535  Sphi...
Q8EE93                 467 IDQWRWKVFSGEITPAQYNQAWWELREKYQGVKAPTP-RSETDFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKALCETA 544  Shew...
WP_013051597           460 IDQWRWKVFSGEITPDQYNQAWWDLREKYQGVKAPIE-RSEADFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKSLCETA 537  Shew...
6S1Y_A                 516 GEYVKgdpektLNNCDIYQSTAAGNQLKEMLALGSSKPWPDAMEVLTGERKMSADAILEYFDPLYQWLLEENkrLGAHVG 595  Afri...
PDM63802               827 SI---------LSEGCIL-SEDTTGKLREAMEKGSSINWLEALKIVTGKGELDVAPLLEYYEPLINWLQNTNevDQVIVG 896 
Q2WG88                 534 KHEGP------LYKCDISNSSEAGQKLHEMLSLGRSKPWTFALERVVGAKTMDVRPLLNYFEPLFTWLKEQN--RNSFVG 605  dome...
PRJNA194094:J421_0092  555 GHTGP------LYRCSFYGSKEAGAKLARMLEAGQSKPWQETLYEMTGERDMDAGAMLEYFAPLKAWLDRQN--AGHPVG 626 
ASGPB:GKIL_2224        539 GYTGP------LHRCSIYANRAAGTKLAAMLAAGQSQPWPDTLYAMTGERQMDASAMLDYFAPLKSWLDAQN--QGKKVG 610 
BAK67040               560 GWKGP------LHRCSFYGNKEVGKRLNAMLEMGASKPWPDALEAFTGSRKMSGKAMLAYFAPLGKWLDQQN--KGKQCG 631 
WP_012048875           548 GWKGP------LHRCSFYGNKEVGAKLDAMLKMGASKPWPDALQAFTGSREIDGSAMIAYFKPLMTWLEKQN--KGQRCG 619  Rhiz...
WP_015456931           536 GWKGP------LHRCSFYGNKEVGANLNKMLEMGMSKPWPDALQAFTGSREMDGTAMIAYFKPLMTWLEQQN--KGKTCG 607  Sphi...
Q8EE93                 545 GDKGP------VHRCSIYGNQAAGEKLNRMLELGSSQPWPMALKEVTGTETMDANAVLDYFAPLKTWLDEQNkaANRQCG 618  Shew...
WP_013051597           538 GDTGP------VHRCSIYGNKAAGSKLNTMLEMGLSRPWPDALKVVTGSPEMDASAVLDYFAPLQVWLNEQNtqAKRQCG 611  Shew...
6S1Y_A                 596 W 596  African malaria mosquito
PDM63802               897 W 897 
Q2WG88                 606 W 606  domestic ferret
PRJNA194094:J421_0092  627 W 627 
ASGPB:GKIL_2224        611 W 611 
BAK67040               632 W 632 
WP_012048875           620 W 620  Rhizorhabdus wittichii
WP_015456931           608 W 608  Sphingomonas sp. MM-1
Q8EE93                 619 W 619  Shewanella oneidensis
WP_013051597           612 W 612  Shewanella violacea
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap