1URZ,1K4R,1K4R,1N6G,1OKE,1PJW,1SVB,2H0P,2I69,2JQM,3IRC


Conserved Protein Domain Family
Flavi_E_C

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cd12149: Flavi_E_C 
Click on image for an interactive view with Cn3D
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.
Statistics
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PSSM-Id: 213392
Aligned: 26 rows
Threshold Bit Score: 128.191
Created: 16-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1OKE: Dengue virus 2 Envelope protein in complex with N-octyl-beta-D-glucoside, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ## ##      ##                                              #               
1URZ_A        311 KFTWKRAPTDsgHDTVVMEVTFSg-tKPCRIPVRAVAhgspdVNVAMLITPNPTIen---ngGGFIEMQLPpGDNIIYVg 386  Tick-borne en...
1OKE_A        305 KFKVVKEIAEtqHGTIVIRVQYEgdgSPCKIPFEIMDle-krHVLGRLITVNPIVtek--dsPVNIEAEPPfGDSYIIIg 381  Dengue virus 2
1PJW_A         16 KFSFAKNPADtgHGTVVIELSYSgsdGPCKIPIVSVAslndmTPVGRLVTVNPFVatssansKVLVEMEPPfGDSYIVVg 95   Japanese ence...
2H0P_A         17 KFSIDKEMAEtqHGTTVVKVKYEgagAPCKVPIEIRDvn-keKVVGRIISSTPLAent--nsVTNIELEPPfGDSYIVIg 93   Dengue virus 4
2I69_A        308 AFKFLGTPADtgHGTVVLELQYTgtdGPCKVPISSVAslndlTPVGRLVTVNPFVsvatanaKVLIELEPPfGDSYIVVg 387  West Nile virus
3IRC_A         14 SFKLEKEVAEtqHGTVLVQVKYEgtdAPCKIPFSTQDek-gaTQNGRLITANPIVtdk--ekPVNIEAEPPfGESYIVVg 90   Dengue virus 1
AAV34154      589 AFTMKKDPTDtgHGTVVMELTYKgidVPCRVPITIARspndgEMVGRMVSVNPLAmtt--ssVFMVEVEPPyGDSNIIVg 666  Iguape virus
YP_001040004  602 TFKMEKHPADtgHGTVVLDVSYQgddAPCKIPIVITSnlaevEPVGRLVSAHPVItak--nvRTMLEVEPPyGDSYIVIg 679  Aroa virus
ABI54475      595 AFTFTKVPAEtlHGTVTVEVQYAgtdGPCKVPAQMAVdmqtlTPVGRLITANPVItestensKMMLELDPPfGDSYIVIg 674  Zika virus
ABI54477      593 KFSFHRNPAPtqHGTVTVDIGYSg-dAPCKVPISVSSeanshKNVGRLVTANPIVmkn--gdSVFVEVEPPfGDSYIVVg 669  Kedougou virus
Feature 1                      
1URZ_A        387 ----ELSHQWFQK 395  Tick-borne encephalitis virus (WESTERN SUBTYPE)
1OKE_A        382 vepgQLKLNWFKK 394  Dengue virus 2
1PJW_A         96 mgdkQINHHWHKA 108  Japanese encephalitis virus
2H0P_A         94 vgnsALTLHWFRK 106  Dengue virus 4
2I69_A        388 rgeqQINHHWHKS 400  West Nile virus
3IRC_A         91 agekALKLSWFKK 103  Dengue virus 1
AAV34154      667 sydnVLKHHWFKP 679  Iguape virus
YP_001040004  680 vgdgRLKQHWFKK 692  Aroa virus
ABI54475      675 vgdkKITHHWHRS 687  Zika virus
ABI54477      670 tgptKINYHWYKP 682  Kedougou virus

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