1JWY,3ZYC,3L43


Conserved Protein Domain Family
DLP_1

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cd08771: DLP_1 
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Dynamin_like protein family includes dynamins and Mx proteins
The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes interferon-induced Mx proteins that inhibit a wide range of viruses by blocking an early stage of the replication cycle. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.
Statistics
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PSSM-Id: 206738
Aligned: 87 rows
Threshold Bit Score: 175.897
Created: 17-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1JWY: Dictyostelium discoideum Dynamin A GTPase binds GDP; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ######            ##     #                                          
1JWY_B        22 LDLPQIVVVGSQSSGKSSVLENIVGrdFLPRGs-GIVTRRPLILQLthlpiad-------dgsqtqEWGEFlh------- 86   Dictyostelium ...
ABI33144      21 IALPQIAVVGDQSSGKSSVLENITGi-PFPKGt-GTVTKCATRITIrralkrttpfsarvsfvingKNSPFkn------- 91   Bigelowiella n...
Q18965       285 DNLPRVVVVGDQSAGKTSVLEMVAQarIFPRGsgEMMTRAPVKVTLseg---------------pyHVAQFrd------- 342  Caenorhabditis...
Q5F499       303 DHLPRVVVVGDQSAGKTSVLEMIAQarIFPRGsgEMMTRSPVKVTLsegphh--------valfkdSSREFdl------- 367  chicken
Q5U3A7       292 DHLPRVVVVGDQSAGKTSVLEMIAQarIFPRGsgEMMTRSPVKVTLsegphh--------vamfkdSSREFdl------- 356  zebrafish
NP_001120510  87 DHLPRVVVVGDQSAGKTSVLEMIAQarIFPRGsgEMMTRSPVKVTLsegphh--------vamfkdSSREFd-------- 150  western clawed...
O60313       286 DHLPRVVVVGDQSAGKTSVLEMIAQarIFPRGsgEMMTRSPVKVTLsegphh--------valfkdSSREFdl------- 350  human
Q9SE83        36 ATFLNVVALGNVGAGKSAVLNSLIGhpVLPTGe-NGATRAPIIIELs-------------------RESSLsskaiilqi 95   thale cress
Q84P77         6 STFLNAVALGNVGAGKSAVLNSLIGhpVLPTGe-NGATRAPIVVDLqrd--------------pglSSKSIvlqi----- 65   Oryza sativa J...
Q7QHP4       244 DHLPRVVVVGDQSSGKTSVLESIAQarIFPRGsgEMMTRAPVKVTLseg---------------pyHVAQFrd------- 301  Anopheles gamb...
Feature 1                                                                    #                   
1JWY_B        87 -kpNDMFYdf-----sEIREEIIRDTDRmtgknk-gisaqPINLKIYSPhv---vNLTLVDLPGItkvpvgdqptDIEQQ 156  Dictyostelium ...
ABI33144      92 --eGPKMNhts---vgKLQKTLERLNELihqnesktdiddIIEVDIEERhdsdavDLSIVDLPGLiatttegqskDLVGS 166  Bigelowiella n...
Q18965       343 --sSREFDltketdlqQLRNETEVRMRNsvrdgk-tvsneVISLTVKGPnl---pRMVLVDLPGVistvtadmarETKDD 416  Caenorhabditis...
Q5F499       368 -tkEEDLA--------ALRNEIEIRMRNsvkegc-tvsteTISLSVRGPgl---qRMVLVDLPGVistvtsgmapDTKET 434  chicken
Q5U3A7       357 -gkEEDLA--------ALRHEIELRMRKsvkegq-tvspeTISLSVKGPgi---qRMVLVDLPGVistvttgmaaDTKET 423  zebrafish
NP_001120510 151 --lSKETDl------aALRNEIEVRMRKsvkngq-tvspeTISLSVKGPgi---qRMVLVDLPGVintvtsgmapDTKDT 218  western clawed...
O60313       351 -tkEEDLA--------ALRHEIELRMRKnvkegc-tvspeTISLNVKGPgl---qRMVLVDLPGVintvtsgmapDTKET 417  human
Q9SE83        96 dnkSQQVSa------sALRHSLQDRLSKgasg----knrdEINLKLRTSta---pPLKLVDLPGL----------DQRIV 152  thale cress
Q84P77        66 dskSQRVSa------sSLRHSLQDRLSKgassgssrgrveGINLKLRTSta---pPLKLVDLPGI----------DQRAV 126  Oryza sativa J...
Q7QHP4       302 --sEREYDltkesdlaELRRDVEIRMRNsvrggk-tvsmdVISMTVKGPgl---qRMVLVDLPGIistqtvdmapDTRDQ 375  Anopheles gamb...
Feature 1                                                            # ##                        
1JWY_B       157 IRRMVMAYIkkqnAIIVAVTPANt--DLANSDALQLAKEVDPegkRTIGVITKLDLMDKGTdamevl------tgrvipL 228  Dictyostelium ...
ABI33144     167 IEKMVSRYAedkrTVILAIMEAHr--DISNSRALAMAEKADEkgeRTVGVLTKMDLVEEATeddvlnv----lnnsrkpL 240  Bigelowiella n...
Q18965       417 IIRMSKAHMenpnAIILCIQDGSv--DAERSNVTDLVSSIDPsgkRTILVLTKVDMAEKNLanpdrikki-legklfpmK 493  Caenorhabditis...
Q5F499       435 IFSISKAYMqnpnAIILCIQDGSv--DAERSIVTDLVSQMDPqgkRTIFVLTKVDLAEKNVaspsriqqi-iegklfpmK 511  chicken
Q5U3A7       424 IFSISKAYMqnpnAIILCIQDGSv--DAERSIVTDLVSQMDPqgkRTIFVLTKVDLAEKNLaspsriqqi-vegklfpmK 500  zebrafish
NP_001120510 219 IFNISKAYMlnpnAIILCIQDGSv--DAERSIVTDLVSQMDPqgrRTIFVLTKVDLAEKNVaspnriqqi-iegklfpmK 295  western clawed...
O60313       418 IFSISKAYMqnpnAIILCIQDGSv--DAERSIVTDLVSQMDPhgrRTIFVLTKVDLAEKNVaspsriqqi-iegklfpmK 494  human
Q9SE83       153 DESMIAEYAqhndAILLVIVPASqasEISSSRALKIAKEYDPestRTIGIIGKIDQAAENSkalaavqallsnqgppktT 232  thale cress
Q84P77       127 DDPMINEYAghndAILLVVIPAMqaaDVASSRALRLAKDIDAdgtRTVGVISKVDQAEGDAktiacvqalllnkgpknlP 206  Oryza sativa J...
Q7QHP4       376 IKHMTEHYMsnpnAIILCIQDGSv--DAERSNVTDLVSQCDPlgkRTIFVLTKVDLAEDLAdpnrirki--lsgklfpmK 451  Anopheles gamb...
Feature 1               #####  #                                                             
1JWY_B       229 TLGFIGVINRSQEDIiakk-----sirESLKSEILYFKNHpiyks----ianrsGTAYLSKTLNKLLMFHIRDTLP 295  Dictyostelium disc...
ABI33144     241 YHGYFAVVNRAQKTLnegk-----slkDARRDEKEWFERNkhymsmdgrcgidnLKRGISKRLRVILSKGVPEILV 311  Bigelowiella natans
Q18965       494 ALGYFGVVTGRGNSSds--------idEIRKYEENFFSTSqllrdgv-lkpsqmTTRNMSLAVSDCFWRMVRDSIE 560  Caenorhabditis ele...
Q5F499       512 ALGYFAVVTGKGNSSes--------ieSIKEYEEEFFQNSkllktsm-lkahqvTTKNLSLAVSDCFWKMVRESVE 578  chicken
Q5U3A7       501 ALGYFAVVTGKGSPNes--------idSIKDYEEDFFQNSrllkdgm-lkahqvTTKNLSLAVSDCFWKMVRESVE 567  zebrafish
NP_001120510 296 ALGYFAVVTGKGNSNes--------idSIKDYEEEFFQGSsllkkgm-lkahqvTTKNLSLAVSDCFWKMVRESIE 362  western clawed frog
O60313       495 ALGYFAVVTGKGNSSes--------ieAIREYEEEFFQNSkllktsm-lkahqvTTRNLSLAVSDCFWKMVRESVE 561  human
Q9SE83       233 DIPWVAVIGQSVSIAsaqsgsgensleTAWRAESESLKSIltgap-----qsklGRIALVDTLASQIRSRMKLRLP 303  thale cress
Q84P77       207 DIEWVALIGQSVAIAs----------aQAAGSENSLETAWn------------aEAETLRSILTGAPKSKLGRIAL 260  Oryza sativa Japon...
Q7QHP4       452 ALGYFAVVTGRGRKDds--------ieTIREYEEKFFKNSklfqsgv-tmshqvTTRNLSLAVADRFWKMVRETIE 518  Anopheles gambiae ...

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