Conserved Protein Domain Family
SGNH_hydrolase_like_2
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cd01834: SGNH_hydrolase_like_2 
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Links
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Statistics
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PSSM-Id: 238872
Aligned: 29 rows
Threshold Bit Score: 124.713
Created: 19-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen instead of an acidic side chain
  • Citation:PMID 7773790
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #                                                          #           
NP_344362     6 GDVIVFAGDSITDReksnna-------------plgygYVNLFYNLMLAKHpe----tkITVINSGISGNTVIDLi---- 64  Sulfolobus solfa...
CAH05122      8 GSHLLFQGDSLTDSgrdrgrdpgggperadanaslghgYVYLVAARAAARApg----hrWRFTNRGVSGDGIADLa---- 79  Streptomyces fra...
CAC95727      1 MKKLLFLGDSVTDAgcdfend-----------relghgYVKMIAEQLEKED--------VTVINRGVSANRVADLh---- 57  Listeria innocua
ZP_01168746   3 AKKILFIGDSITDHgrredp------------eqigfgYVRYLRDYYMTAFpe----kaLEFINRGVGGNRVTDLa---- 62  Bacillus sp. NRR...
ZP_01116385   1 MSHWIFLGDSVTDCqrkrarryq------gqpealgqgWVRYVANKLAANGq------aVDVWNRGYSGAMTQEL----- 63  Reinekea sp. MED297
ZP_01107239  37 ANKILFLGNSITYSg----------------------qYISYIETYLTLKYpe----kkLEFINVGLPSETVSGLsehnh 90  Flavobacteriales...
ZP_01093618  29 GKRVVFLGDSITQAg----------------------gYVTFVDYYLEKLYpq----qdFDIIGLGLASETLSGLseenh 82  Blastopirellula ...
AAO77728    220 KINVVFVGNSITEAt-----------------------YLKITPPEWTTIYldsl-gydVQSVNCGKSGYTTFDFlpgkg 275 Bacteroides thet...
YP_465252   212 DDVWVFLGDSIGAGvfdr-----------------apaHRPSFADAIARAHpg----yqPAMIDAGFCRARTWEVa---- 266 Anaeromyxobacter...
CAH09445     22 GINIVYIGNSITQGall-------------------ktPATEAPPVQASQYieqatkqsVAFRNCGVSGATTLNFlpi-- 80  Bacteroides frag...

Feature 1                                               #                                       
NP_344362    65 -----------dRWDDDVLSyk--------pNWISILIGINDlhkflgg--lttfnpENYYENLRRLLKYTr-----kVL 118 Sulfolobus solfa...
CAH05122     80 -----------aRWRTDTLEqt--------pDVLSVLVGVNDarrvveg-dcwdidaDRFREAYDELLARTr-----rAL 134 Streptomyces fra...
CAC95727     58 -----------rRIEADAISlq--------pDVVTIMIGINDtwfsfsr--wedtsvTAFKEVYRVILNRIk------TE 110 Listeria innocua
ZP_01168746  63 -----------dRWKADVIDiq--------pDLVSISIGINDvwrqldspgivqigpERFKEVYEDLLTEVk------EK 117 Bacillus sp. NRR...
ZP_01116385  64 ------------MQQVDWWPdqege--pitaDLVSLMIGINDiwhpfwk--gtghaiDDSLKAYERLIGEL-------KN 120 Reinekea sp. MED297
ZP_01107239  91 aqgkfprpdlkeRLHRVLSKak--------pDFVFANYGINDgiylpf----dnerfKKFKDGILWMHNEV-------AK 151 Flavobacteriales...
ZP_01093618  83 aggkfprpclfeRLQRLLDKak--------pDVVFACYGINDgiyqpl----dsqrfAAFQNGVKQLIAQCq------AA 144 Blastopirellula ...
AAO77728    276 -------gfkyvIRKADELYkkd-----krnLVFSFCLGVNDsactgtn--gapvsaEQYESNMQLIIDSLc-----fRF 336 Bacteroides thet...
YP_465252   267 ------------ERIDEVLAlnp------daKVFAIVLGANDgd------------lARLRAGLERIVARVr------AA 310 Anaeromyxobacter...
CAH09445     81 ----------aeRQFPNVKSaaqelsqrkgtLLFSIMLGTNDsacngpf--gspvepVSYYTNMKTIIDELlslypecKV 148 Bacteroides frag...

Feature 1                                                                                       
NP_344362   119 NNVNFILMTPFyisrnkleg-gfrakvlelLPQYIEKVRLLSNefs-----------atyIDLHDTFkklvnir----ep 182 Sulfolobus solfa...
CAH05122    135 PATRLLLCEPFclpagrdpd--fdaalaaqVQTRQKAVADLAAahr-----------aelVRLQPVFdealrra----pa 197 Streptomyces fra...
CAC95727    111 TNAELILMEPFvlpyped-----rkewrgdLDPKIGAVRELAAefg-----------atlIPLDGLMnalaikh----gp 170 Listeria innocua
ZP_01168746 118 TKAEIVLMEPTvieedvh------segnrlLTPYVEAVHELAEqfq-----------avvVPEHKAFlrylesg----gk 176 Bacillus sp. NRR...
ZP_01116385 121 RTRRLVLVEPValpcgev-----tqdwrapLNELTAGQQKLADaag-----------clwVPMQEALmhdargh-----n 179 Reinekea sp. MED297
ZP_01107239 152 SGAEIVHLTPPvydgpnt------avydnvMDIYSHWLLSKRYtde-----------wkiIDIHSPMkgqlqkervqnpk 214 Flavobacteriales...
ZP_01093618 145 GVQQIYLVTPPiydattqp---gefnydavMTEYAAWEMALKAprv------------qtIDLHSAMrkardaq-----t 204 Blastopirellula ...
AAO77728    337 PEAKVVLHYPIwyspntynsamylkeglkrLQTYFAAIERLGRknkgr-------amigdTKGFKVFrkhykkyht-pqe 408 Bacteroides thet...
YP_465252   311 GRIPVVARIPFqtry-----------gydwVAQKNAVVDAVVAehgl----------lpgPDLYAWFrdrp--------- 360 Anaeromyxobacter...
CAH09445    149 VIHQPIWYSPNtynsamy-----laaglkrLKSYTPMIHKLVDhysqanpnqvflgdtaaSDFFRNNyqsyftp----en 219 Bacteroides frag...

Feature 1            #  #                
NP_344362   183 nvyapEPVHPNFTGHMVIALKLLEA 207 Sulfolobus solfataricus P2
CAH05122    198 ahwshDGVHPTPAGHQLLADAWVSA 222 Streptomyces fradiae
CAC95727    171 tflaeDGVHPTKAGHEAIASTWLEF 195 Listeria innocua
ZP_01168746 177 iklttDGVHMTSAGDMLMARVWVEA 201 Bacillus sp. NRRL B-14911
ZP_01116385 180 aeylhDGVHPTDLGHRWLSIRWLRA 204 Reinekea sp. MED297
ZP_01107239 215 ftfapDGVHPNKEGHWVMAQQVLLS 239 Flavobacteriales bacterium HTCC2170
ZP_01093618 205 evfakDKVHPGPAGHLLMAKTILSA 229 Blastopirellula marina DSM 3645
AAO77728    409 gkrgvFYLHPNAEGARVLGRLWSEG 433 Bacteroides thetaiotaomicron VPI-5482
YP_465252   361 -drlaDGLHPDAAGSVAMSRLWAEA 384 Anaeromyxobacter dehalogenans 2CP-C
CAH09445    220 gnagtFYLHPNKEGAGILGKYWAEA 244 Bacteroides fragilis NCTC 9343

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