1DSY,2UZP,3GPE,1A25


Conserved Protein Domain Family
C2_PKC_alpha_gamma

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cd04026: C2_PKC_alpha_gamma 
Click on image for an interactive view with Cn3D
C2 domain in Protein Kinase C (PKC) alpha and gamma
A single C2 domain is found in PKC alpha and gamma. The PKC family of serine/threonine kinases regulates apoptosis, proliferation, migration, motility, chemo-resistance, and differentiation. There are 3 groups: group 1(alpha, betaI, beta II, gamma) which require phospholipids and calcium, group 2 (delta, epsilon, theta, eta) which do not require calcium for activation, and group 3 (xi, iota/lambda) which are atypical and can be activated in the absence of diacylglycerol and calcium. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-I topology.
Statistics
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PSSM-Id: 175992
Aligned: 23 rows
Threshold Bit Score: 188.239
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1DSY_A; Rat PKC C2 domain binds 2 Ca2+

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #     #                                        
1DSY_A         5 RGRIYLKAEVTd-----eKLHVTVRDAKNLIPMDPnGLSDPYVKLKLIPdpk--neSKQKTKTIRSTLNPQWNESFTFKL 77  Norway rat
125543       194 RGKLLLYVELKg-----nNLKVDIKEAANLIPMDTnGFSDPYIAVQMHPdrs--grTKKKTKTIQKNLNPVFNETFTFEL 266 fruit fly
CAA73362     162 RGRIRLKINFSqkg-eegALTIDIFEAKNLIPMDPnGQSDPYVKLKLLPdt---tqNKQKTKTIRKCLNPVWNEKFVYKI 237 Hydra vulgaris
3114956      148 RGRIKVTFSTLqlddahiRVNIMIHECRNLPPMDAnGLADPYVKLRLYPeptdtpnIKQKTERKEKTLEPKFEEDFFYDV 227 Suberites domun...
3114989      164 RGRLFLGLKLTettpvlkSLEVVVKEAKNLPPMDAnGLADPYVKLWLSDdpq--kaTKKKTETKMKTLNPVWGEKFSFNL 241 Sycon raphanus
Q16974       143 RGRILIKGAVKg-----sKVLVEILEAKNLCPMDPnGLADPYVKVKLIPyda--hkLKLKTKTIKASLNPVWNESFTVDI 215 California sea ...
AAR00731     154 RGRIYLKISWQd-----nRFVVEVKEGRNLIPMDPnGLADPYVKIKFGPtde--lgRKFRTKTIKSNLNPVWDEKFTIDL 226 Schistosoma man...
CAI30830      15 RGRIHMKIKYLakgndsgELQVEIREAKNLIPMGPtGQSDPYVKIKLHP-------KKEKTKVMKKNLNPVWNNSFSFRI 87  Hydractinia ech...
XP_001748495 118 RGQIKLNVSLNsng-dnvDISVEVLQAANLLPADItGLADPYVKMYIQPdps--kkTKQKTKVVKKSLNPEWNEKFTWTL 194 Monosiga brevic...
XP_002110115 151 RGRINLSIRYQetsptagMLLVEVRECKNLIPMDPnGLSDPYVKIKLLPdpn--ksTKRKTPICKATLNPIFNMKFDFYI 228 Trichoplax adha...
Feature 1                        # #     #                                          
1DSY_A        78 KPSd--KDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKm-------PASGWYKLLNQEEGEYYNVP 135 Norway rat
125543       267 QPQd--RDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKe-------PVDGWYKFLSQVEGEHYNIP 324 fruit fly
CAA73362     238 GPNd--KDKRLCIEVWDWDLATSNDFMGSMSFGVSELMKd-------EVDGWYKLLNAEEGEYYNVP 295 Hydra vulgaris
3114956      228 NMNh--LDTFLVIEVWDWDKFTANDYVGGFALRIGEIIEltk---mePHSSWYKLLDEKRSKTHHER 289 Suberites domuncula
3114989      242 TQGd--LKRSLIIEVWDWDRTTRNDFIGKMTFTLDEITKmekdpasgFNDQWFKLLNESEGSAYNVP 306 Sycon raphanus
Q16974       216 GPEd--NSKRLSLEVWDWDRTSRNDFMGSLSFGISELIKs-------PVEGWFKLLNQEEGEFYGVP 273 California sea hare
AAR00731     227 HPDd--ESKRLHFEVWDWDRTSRDDFMGALSFGVTELIKk-------PIDCWFKLLSQEEGEYYSIP 284 Schistosoma mansoni
CAI30830      88 SKQd--FDKRLRVQVWDWDMATKNDFMGSMSFGVSELVKd-------QIEGWFKLLNKEEGKFYNVP 145 Hydractinia echinata
XP_001748495 195 SSAtklEHRFLTIEVWDWDRITRNDFMGAMAFELKELEDpd-----tIKAGWFILLDQEQGRFFNFP 256 Monosiga brevicollis MX1
XP_002110115 229 TEKd--HERRLNVSVWDWDKFGGNEFMGALSFGVSELIRr-------PVEGWYKLLDQGEGEFYNVP 286 Trichoplax adhaerens

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