4GFU,4NND


Conserved Protein Domain Family
PTPc-N18
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cd14603: PTPc-N18 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 18
Tyrosine-protein phosphatase non-receptor type 18 (PTPN18), also called brain-derived phosphatase, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. The N-terminal catalytic PTP domain of PTPN18 blocks lysosomal routing and delays the degradation of HER2 by dephosphorylation, and its C-terminal PEST domain promotes K48-linked HER2 ubiquitination and its destruction via the proteasome pathway.
Links
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Statistics
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PSSM-Id: 350451
Aligned: 7 rows
Threshold Bit Score: 540.568
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 15 residue positions
Conserved feature residue pattern:x x x x x x C x x x x x R x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:4GFU: human PTPN18 binds Her2-pY1248 phosphopeptide; contacts at 4A
  • Structure:4NND: Human PTPN18 binds Her2 peptide; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ####                                         
4GFU_A        24 AGEFSDIQACSAAWKADgvcstvaGSRPENVRKNRYKDVlpyDQTRVILSLLqeegHSDYINGNFIRGvdgslAYIATQG 103 human
4NND_A        22 AGEFSDIQACSAAWKADgvcstvaGSRPENVRKNRYKDVlpyDQTRVILSLLqeegHSDYINGNFIRGvdgslAYIATQG 101 human
NP_001013470  27 SSEFSLIRKKTASLKEDyglttnaGGMKENVKKNRYRDIlpyDQTRVCLTPTtseyQSDYINANFVKGavrnrTYIATQG 106 zebrafish
NP_001121240  28 GTEFQEIRTQAAAFRNDytt--evGASQENLKKNRYKDIlpyDQTRVQVSFLdeeeGSDYINASFIKGldisrRYIATQG 105 African clawed ...
Q99952        27 AGEFSDIQACSAAWKADgvcstvaGSRPENVRKNRYKDVlpyDQTRVILSLLqeegHSDYINGNFIRGvdgslAYIATQG 106 human
XP_014353416  26 AKEFNEIKYQCAQFKKSdgfvttvGGSKENLKKNRYKDIlpyDQTRVILSLLveegETDYINANFVKGpdnerCYITTQG 105 coelacanth
XP_008101774  31 AEEFQEIKARAVAFQQQqsisteaGGNKENIKKNRYKDIlpyDQTRVVLNLLaeegQTDYINANFIQGvdnkrCYIATQG 110 green anole

Feature 1                                                                                        
4GFU_A       104 PlphtllDFWRLVWEFgvKVILMACREIENGRKRCERYWAqeqe--plqtGLFCITLIKEKWLNedIMLRTLKVTfqkeS 181 human
4NND_A       102 PlphtllDFWRLVWEFgvKVILMACREIENGRKRCERYWAqeqe--plqtGLFCITLIKEKWLNedIMLRTLKVTfqkeS 179 human
NP_001013470 107 PlsstvvDFWRMIWQHnvKVIIMACREIEMGKKKCEVYWAstsd--tstlGPFTVSTLEESRPNeeVIVRTLVVNycdeA 184 zebrafish
NP_001121240 106 PlshtiqDFWRMIWQYevKVIVMACREVEHGKRKCERYWPlddaaapaqfGPFTISKVEKNRVNaeVIYRKLRITfkevS 185 African clawed ...
Q99952       107 PlphtllDFWRLVWEFgvKVILMACREIENGRKRCERYWAqeqe--plqtGLFCITLIKEKWLNedIMLRTLKVTfqkeS 184 human
XP_014353416 106 PlsqtvvDFWRMIWEYrvKVIIMGCREFEMAKKKCECYWAshre--tleyGPFTVTNVKEEEVNeeTVIRMLSVTfcdeS 183 coelacanth
XP_008101774 111 PlphtviDFWRMVWQYrvKVIVMACREVEMGKKKCERYWPlaee--tlsfGPFSVTQVKEEELNpdVILRMLTLKyqqeE 188 green anole

Feature 1                    ##                              #######                             
4GFU_A       182 RSVYQLQYMSWPDRGVPssPDHMLAMVEEARRLQGSgpePLCVHSSAGCGRTGVLCTVDYVRQLLltqmiPPDFSLFDVV 261 human
4NND_A       180 RSVYQLQYMSWPDRGVPssPDHMLAMVEEARRLQGSgpePLCVHSSAGCGRTGVLCTVDYVRQLLltqmiPPDFSLFDVV 259 human
NP_001013470 185 RKVSHFQYTAWPDHGIPdmPDGILGMMELARQKQGNqtdPVVIHCSAGCGRTGVICAVDYVNDLLlteqiQEDFNILDLV 264 zebrafish
NP_001121240 186 RDISHFQYVAWPDHGIPdsYSCFLEMIQLVPKYQQEsrvPLCVHCSAGCGRTGVICMVEYIQSLLhlqrvPPDFSIFNAV 265 African clawed ...
Q99952       185 RSVYQLQYMSWPDRGVPssPDHMLAMVEEARRLQGSgpePLCVHCSAGCGRTGVLCTVDYVRQLLltqmiPPDFSLFDVV 264 human
XP_014353416 184 RVVYQFQYTAWPDHGIPdsCDCILQFIELMHEYQGRdktPFCIHCSAGCGRTGVICAVDYVRQLLltsriQDDFSIFNII 263 coelacanth
XP_008101774 189 RVISHFQYVAWPDRGIPdtYGCFLDMIEQVRNKQGEdtvPICVHCSAGCGRTGVICTLEYIRRLLlkqriPPHFSIFDVV 268 green anole

Feature 1                #  #                
4GFU_A       262 LKMRKQRPAAVQTEEQYRFLYHTVAQMF 289 human
4NND_A       260 LKMRKQRPAAVQTEEQYRFLYHTVAQMF 287 human
NP_001013470 265 LELRRQRPSAVQTKEQYGFVFHTVAQMF 292 zebrafish
NP_001121240 266 LNMRRQRPSAIQTREQYEFLYHAVTEMF 293 African clawed frog
Q99952       265 LKMRKQRPAAVQTEEQYRFLYHTVAQMF 292 human
XP_014353416 264 LEMRKQRPAAVQTKEQYEFVYQTVAELF 291 coelacanth
XP_008101774 269 LEMRKQRPAAVQTQEQYEFVYHAVTEMF 296 green anole

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