Conserved Protein Domain Family
Fe-ADH-like
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cd08185: Fe-ADH-like 
Iron-containing alcohol dehydrogenases-like
This family contains iron-containing alcohol dehydrogenase-like (ADH) proteins. Alcohol dehydrogenase catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase fold and is a member of the iron-containing alcohol dehydrogenase-like family. They are distinct from other alcohol dehydrogenases which contain different protein domains. Proteins of this family have not been characterized.
Links
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Statistics
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PSSM-Id: 341464
Aligned: 83 rows
Threshold Bit Score: 377.223
Created: 29-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activemetal binding
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                                               
CDL91375    5 YHLPVNLIFGAGKIEVLGEETakyGQKAFIVTGrnst-kktGLLDKALNLLeksGIEYVVFDkvaQNPLttTVEEGAALa 83  Clostridium tyrobu...
SJZ54152    6 YYQPTRLLFGSGRRSEAGAAAktlADSALFVVDpvllkvaaDKVEDVQKSLseaGVRAVTFSdvvPNPTldAIQRGAEIa 85  Aurantimonas sp. U...
ADQ45458    7 YYQPTRIIFGVGRRKELGIWAkrfGKKVLVVVDpnvekflsQQYQEMLDSLhseGIETIVFDhviPNPTldSIQEGAEVa 86  Caldicellulosirupt...
EEG41412    6 FFIPTQIRFGVGRLKELKEFAptyGQKCLLVSRplng-slkETYSEIIALLqavNIEIFFFDevvPNPTieGVENGVSIa 84  Flavobacteria bact...
EDL53592    6 HFQPTKLAFGLGEIQRIGQLVaqyGQRCLVVSEpife-avrPAYDRIFSLLaasGVEVTHFDgvvPNPPttVVEQGRQLa 84  Vibrio shilonii AK1
CCL73775    4 FYQPSRINFGQGTLSELPRIIgkyGKKCLLVTTpnve-pldKLYKRVTLNLiekGIEVVHFDrvePNPTveLVNEGFELa 82  Clostridioides dif...
EFP60156    4 YYQPTKIHFGAGQLSELGHVCksyGKTCFLVTTpda--plqPLYERVKKLLdaeGIRVIHFDrvePNPSveIVEQGFAMl 81  Erysipelotrichacea...
EFR37897    4 YYQPTKIHFGAGQLNELGHICrgyGKTCFLVTTpda--plqPLYERVKKLLdaeGISVIHFDkvePNPSveIVEQGFAMl 81  Clostridium sp. HGF2
EDO59330    6 YYAPTEIIFGCGKATAIGEVVrryGETALLVTDdsk--pmaAIAEKVMQLLrksGISTVHFCgvkPNPTtnIVTEGARMa 83  [Clostridium] lept...
EFC05486    5 NYQPTKIVFGKNKVDSLAQYAleyGQKAFVIGPvlce-aiqPLLARIENILs-kKMTFQTFYqvePNPSirTVDAVVKMm 82  Bulleidia extructa...

Feature 1                 ###  #  #                                          ## #             
CDL91375   84 vqtgCDVVIGIGGGSIMDASKSIAFmvk-nkGDISDYIfgriy---------getaLPIILVPTTAGTGSEGNNFSVLTN 153 Clostridium tyrobu...
SJZ54152   86 ksegVKAVIGMGGGSAIDTAKAIAVaat-hpGTAWDYLyfkka--------ptsatLPIMAINTTSGTGTQTSKVSVFTN 156 Aurantimonas sp. U...
ADQ45458   87 krekVDFVIGIGGGSSIDTAKAIAVaat-heGSAWDYLyfkke--------ptektLPIIGVPTTAGTGTQTSRVSVLTN 157 Caldicellulosirupt...
EEG41412   85 vknkVDFVLGVGGGSVLDTAKLIAFlhnsetKIDWDKAisdydnpfs-mtpspkesLPFIAISTTSGTGSQCTQAAVVSD 163 Flavobacteria bact...
EDL53592   85 vsehCDVILAVGGGSSIDTAKVISAtin-tkHIDWSHWfstydspfsdiaalpapiVPMLAVPTTSGTGSQVTQAAVITD 163 Vibrio shilonii AK1
CCL73775   83 kkesVDVVLAVGGGSSIDTAKVLALtfg-leKIDWDYMfstytnpfkiydkvsekeLPLIVVSTTSGTGSQVTQAAVISR 161 Clostridioides dif...
EFP60156   82 keqpADFVLAVGGGSSIDTAKAIAFang-kdSIDWDYLfneynspfayyasyskehLPLLSVPTTSGTGSQVTQAAVITR 160 Erysipelotrichacea...
EFR37897   82 keqpADFVLAVGGGSSIDTAKAIAFang-keSIDWDHLfneysspfayypsysekhLPLLSVPTTSGTGSQVTQAAVITR 160 Clostridium sp. HGF2
EDO59330   84 knhgAQVVIGLGGGSSMDTAKAIAVeat-heGTAWDYNchtqg--------ptektLPIIAIGTTAGTGSQVTQCSVITR 154 [Clostridium] lept...
EFC05486   83 rdfePDVVIGVGGGSVLDVAKISSIlyg-nkQYTWDFLfdtfndfrk-hyekmtnrLPLFAIPTTSGTGSQCTQACVLTD 160 Bulleidia extructa...

Feature 1          ##                 #       #      #   #                                    
CDL91375  154 pkngDKKSLRtnaIYAKASIIDPELMMtmPKSIIASVGFDALTHNIEAYiskasqpitEIQALYGINLLSENLIKvyndp 233 Clostridium tyrobu...
SJZ54152  157 teesCKSAMWndnLLCRIAIIDPELMLslPTGVTASTGFDIFTHTFESYintgaseavDAIALDAIARVLRSLPVavvng 236 Aurantimonas sp. U...
ADQ45458  158 teekCKSAIAsdnIICKVAIVDPELTLtvPPAVTASTGFDVFTHCFESYinvnnqpyvDMLALEAIGIVIKYLRKaydnp 237 Caldicellulosirupt...
EEG41412  164 tkskNKITLFhagLFPVIAIVDPELMCsvPSGVTAATGFDAFTHAFESFlggrtspmtEQMSLQAIQLVLDNLPKaiadl 243 Flavobacteria bact...
EDL53592  164 pvqkAKLTLFhpeFFPKEAVIDPELMLtlPPRMTAMTGFDAFSHAFESFtgtrpspfvDQLALQAMKLVVENLPHvvadg 243 Vibrio shilonii AK1
CCL73775  162 g--sEKNTIFhqnCFSKECIVDPELMLtlPERITASTAFDAFTHAFESYinpnandftEIMSEKSMELVINYLPKvmedk 239 Clostridioides dif...
EFP60156  161 g--kEKITFFhpdNFSQETILDPELMLtlPKRMSAATGFDAFTHAFESYinanashysAMDSMEAMRLVIENLPSvlqep 238 Erysipelotrichacea...
EFR37897  161 g--kEKITFFhpdNFSQETILDPQLMLtlPKRMSAATGFDAFTHAFESYinanaspysAMDSMEAMRLVIDHLPHvledp 238 Clostridium sp. HGF2
EDO59330  155 tadkDKSAIWhrnIFPRVAIVDPELTAtmPKSVTAQTGFDAFCHNFEAYlsvntnplvEVMALEAIRIINENLPKvledg 234 [Clostridium] lept...
EFC05486  161 td-kLKKTIFhqdLYATLAILDPTLTLslPPAITKATAFDAFSHCVESFlrse-nsicNLLAKEGIKKVTKNLPLvlke- 237 Bulleidia extructa...

Feature 1                                 #   #          #                                    
CDL91375  234 kdleAWEKVTLASTLGGMVIGisgvaASHGLEHPVSglk-nvVHGKGLAALMPTIIERsfksspekfani--------sk 304 Clostridium tyrobu...
SJZ54152  237 snlsAREDLAWADTLAGQCLAnvgttLPHAAGQPISghfpkvSHGESLAVIYPAFAEFtwrgavgkfakvarmfnpalst 316 Aurantimonas sp. U...
ADQ45458  238 gdlgARTKMAWADTLAGCCLAnvgttIPHALGQAIGghfphvSHGQSLAVVYPAFLDYtvdwaierfakvarmfnpelek 317 Caldicellulosirupt...
EEG41412  244 knieVRSNLAWADTLAGMCLAnggadLPHPLGEIIGgicpriAHGDTLAIVYPAFLNYkadkapdkfiqv-------anh 316 Flavobacteria bact...
EDL53592  244 snleGRCQLAIADTLGGISLAnggagAPHPLGEILGshktnlPHGLTLAVVYPAYVKQqwrkqperyaqvae---lfgav 320 Vibrio shilonii AK1
CCL73775  240 nnieYRTKLAVADTLGGSSLAnagaaAPHPLSEIIGgvt-hiPHGEALAIVFPKFAEKfykdniekfakvarmlnqelek 318 Clostridioides dif...
EFP60156  239 qnlkYRTNMCLADTLAGRALAnsgasAPHPLSEIIGgiv-hlPHGEALAVVFPAFIQHmaeknrerfa-----------d 306 Erysipelotrichacea...
EFR37897  239 qnleFRTNMCLADTLAGRALAnsgasAPHPLSEIIGgiv-hlPHGEALAVVFPAFIQHmadknkerfa-----------d 306 Clostridium sp. HGF2
EDO59330  235 snmeARSQMAWADTLGGLTNSnagvtLPHGLGMQVGghcpqvTHGQALAAFYPAFTRYtypaaiekfatvgrilnselcg 314 [Clostridium] lept...
EFC05486  238 nrieYREELMLADTFGGISLSncgamLPHPLSEIIGsyt-niCHGEALAIVYPPFLHHtlqkyqkkyaalarylfptrkf 316 Bulleidia extructa...

Feature 1                                                                          
CDL91375  305 ilggkdendCSKVLGKLLEDLNLnitlgemGITHEDVDWMAENCMkvsmaslknnpkqfncEEIKEIYH 373 Clostridium tyrobutyricum DIV...
SJZ54152  317 aseevaaqsLELEIERFLKMIGLyrrlddfGITPADIPPILAHAMefpdsqg--npivpseEDMRQIYM 383 Aurantimonas sp. USBA 369
ADQ45458  318 vsdkeaayaLKQEIVSFLKSINLyytmedfGIKKEDVKDLVKHAIefpdnrv--nprvpdeKDLEELYL 384 Caldicellulosiruptor kronotsk...
EEG41412  317 lnlkadpgaLVEAILNLFKITGLssalekaNLTQQEIESIKGHPLlsqlq-------pensDRIHQMMD 378 Flavobacteria bacterium MS024-2A
EDL53592  321 gstddkassLARYLVQFLERIGLesnltqiGVTKDDVLYLEPAFCfdlp--------ltsrQEMKSILH 381 Vibrio shilonii AK1
CCL73775  319 veddeaaktLGNEIESFLKRVGLktkmsefNVTKEQLEQITSCPVlgflp-------fgkkEDLVEILE 380 Clostridioides difficile E28
EFP60156  307 vaklfgsedLYTAMTDFLETIGLhkklkdfGVSEDEFHEILASPIldhlp-------fgsrEELEAILK 368 Erysipelotrichaceae bacterium...
EFR37897  307 vaklfgsddLYTAMIEFLETIGLhkklkdfGVSEEDFQEILASPVldhlp-------fgsrEELEAILK 368 Clostridium sp. HGF2
EDO59330  315 ldnvaaakqCCEEIDKFLQRIGLwigyselGVSMEDIREISDCGQvlgdyln--nprvatiDEMYELLI 381 [Clostridium] leptum DSM 753
EFC05486  317 sdeidaakcFIEMVDTFMQECELnkhisdyNMDQDTIDHIHMFITnlhlp-------meseETIENILK 378 Bulleidia extructa W1219

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