Conserved Protein Domain Family
U2AF_lg

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TIGR01642: U2AF_lg 
U2 snRNP auxilliary factor, large subunit, splicing factor
These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.
Statistics
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PSSM-Id: 273727
Aligned: 4 rows
Threshold Bit Score: 646.951
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAG51641      65 RDREKDRD-------REKSRDRDReksRDRDRDRERSKDRQRDRHHR-----------DRHRDRSRERSEKrddld---- 122 thale cress
AAH08740       4 FDEFERQL-------NENKQERDK---ENRHRKRSHSRSRSRDRKRR-----------SRSRDRRNRDQRS--------- 53  human
P36629        22 RDEEPRRErgsggigREDPRGHYG---SERPRRRRRDESDFR-RHREsrers--yredERPRRERRYDDYEprslr---- 91  Schizosaccharom...
XP_001348830 270 KDKWRDRS-------KEKSRQRSRdrsKERSRQRSRDRWRDRSRDRWgldrrrsrykdSRDRNKFSYHSRSissdeehys 342 Plasmodium falc...
AAG51641     123 ----ddhhrRSRDRdRRRSRDRDREVRHRRRSRSRSRSRSERrsSKRRSGFDMAPPDMLAATAVAAAAGQVP-SVPTTAT 197 thale cress
AAH08740      54 ---------ASRDR-RRRSKPLTRGAKEEHGGLIRSPRHEKK--KKVRKYWDVPPPGFEHITPMQYKAMQAAgQIPATAL 121 human
P36629        92 ----yssvgRSRSPpPSRERSVRSIEQELEQLRDVTPINQWK---RKRSLWDIKPPGYELVTADQAKMSGVF-PLPG-AP 162 Schizosaccharom...
XP_001348830 343 knkkrtkrrKSRHNiDKDSYSSSSNSTHRRRNRKSSSSNNTRkdDNNSIQKKRKKSKWDTVDECLLNNNLLNnSVSGIFQ 422 Plasmodium falc...
AAG51641     198 IPGMFSnmf-----pmvPGQQLGALPVLpvqAMTQQATRHARRVYVGGLPPTANEQSVSTFFSQVMSAIGGNTAGp---- 268 thale cress
AAH08740     122 LPTMTP-----------DGLAVTPTPVP---VVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAP----- 182 human
P36629       163 RAAVTDpekllefarsaEGSIIAPPPPL-----QPGASRQARRLVVTGIPNEFVEDAFVSFIEDLFISTTYHKPE----- 232 Schizosaccharom...
XP_001348830 423 KSSLTVtgn-----liaQNNKITDLSRN---PYEQDTDKKQRKLYIGNIPPNSKQEDVVDFFNNSILAVIKDSSLdvkig 494 Plasmodium falc...
AAG51641     269 ----GDAVVNVYINHEKKFAFVEMRSVEEASNAMALDGIILEG-VPVKVRRPTDYNPSLaatlgPSQPNPNLNLGAVgl- 342 thale cress
AAH08740     183 ----GNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQG-QSLKIRRPHDYQPLP-----GMSENPSVYVPGV--- 249 human
P36629       233 ----TKHFSSVNVCKEENFAILEVATPEDATFLWGLQSESYSNdVFLKFQRIQNYI-VPqitpeVSQKRSDDYAKND--- 304 Schizosaccharom...
XP_001348830 495 dvqlMPVIKCEIFNSDSRFCFLEFRTVQITWLCLKLDSIPYNN-YCLRIGRPHDYIPPPegdpaFTTVFTDINMDVFekl 573 Plasmodium falc...
AAG51641     343 ----ssGSTGGLEGPDRIFVGGLPYYFTEVQIRELLESFGPLRGFNLVKDRETGNSKGYAFCVYQDPSVTDIACAALNGI 418 thale cress
AAH08740     250 ------VSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGM 323 human
P36629       305 ----------VLDSKDKIYISNLPLNLGEDQVVELLKPFGDLLSFQLIKNIADGSSKGFCFCEFKNPSDAEVAISGLDGK 374 Schizosaccharom...
XP_001348830 574 rpskpvNVKTSSDEENRLYIQNLPHDLKDEQIKDLLEQFGDLKAFNIIKDLNTGLNKGYGFFEYEDSSCTQLAIHALNGF 653 Plasmodium falc...
AAG51641     419 KMGDKTLTVRRAIQGAIQPKPEQEE----------------VLLYAQQQIALQRLMFQ-------------PGGTPTKIV 469 thale cress
AAH08740     324 QLGDKKLLVQRASVGAKNATLSTIN----------------QTPVTLQVPGLMSSQVQ-------------MGGHPTEVL 374 human
P36629       375 DTYGNKLHAQFACVGLNQAMIDKSNg---------------MAILTELAKASSQSI-------------------PTRVL 420 Schizosaccharom...
XP_001348830 654 VCGQNILNVKKATFNKQPTTITTNNnmnnqnpnfialpnnsDVPVTLLPSSISQKILSnsiiglqvqasrkIGEKSSKVV 733 Plasmodium falc...
AAG51641     470 CLTQVVTADDLRDDEEYAEIMEDMRQEGGKFGNLVNVVIPRPnPDHDPTPGVGKVFLEYADVDGSSKARSGMNGRKFGGN 549 thale cress
AAH08740     375 CLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRP-VDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANR 453 human
P36629       421 QLHNLITGDEIMDVQEYEDIYESVKTQFSNYGPLIDIKIPRSiGTRNSGLGTGKVFVRYSDIRSAEVAMEEMKGCKFNDR 500 Schizosaccharom...
XP_001348830 734 QLTNAVFQEDLIVDSQYEEILKEVKEEAEKYGTLQNIVIPKPnKDLSYTEGVGKIFLHYADEATARKAQYMFNGRLFEKR 813 Plasmodium falc...
AAG51641     550 QVVAVYYPEDKYAQGDY 566 thale cress
AAH08740     454 VVVTKYCDPDSYHRRDF 470 human
P36629       501 TIVIAFYGEDCYKANAW 517 Schizosaccharomyces pombe 972h-
XP_001348830 814 VVCAAFYSEEHFLKGKY 830 Plasmodium falciparum 3D7
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