4YM4,4ZGI,6L9V,6L9W,6L9U


Conserved Protein Domain Family
FHA_TIFA

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cd22714: FHA_TIFA 
Click on image for an interactive view with Cn3D
forkhead associated (FHA) domain found in TRAF-interacting protein with FHA domain-containing protein A (TIFA) and similar proteins
TIFA, also called putative MAPK-activating protein PM14, putative NF-kappa-B-activating protein 20, or TRAF2-binding protein (T2BP), is an adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). It promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling. TIFA contains an FHA domain, which is a small phosphopeptide recognition module.
Statistics
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PSSM-Id: 438766
Aligned: 11 rows
Threshold Bit Score: 203.036
Created: 14-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
phosphopeptide
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:4YM4; Homo sapiens TIFA in complex with its Thr9 phosphorylated N-terminal peptide 1-15, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ###       # ## ##                        
4YM4_A         4 VTCLQXTVYHPgqlqcGIFQSI-SFNREKLPSSEVVKFGRNSniCHYTFQDKQVSRVQFSLQLFKKFNSSvLSFEIKNXS 82  Homo sapiens
4ZGI_A         4 VTCLQXTVYHPgqlqcGIFQSI-SFNREKLPSSEVVKFGRNSniCHYTFQDKQVSRVQFSLQLFKKFNSSvLSFEIKNXS 82  Homo sapiens
6L9V_A        13 VTCLQMTIYHPgq-qsGIFKSIrFSSKEKFPSIEVVKFGRNSnmCQYTFQDKQVSRIQFVLQPFKQFNSSvLSFEIKNMS 91  Mus musculus
6L9W_A        13 VTCLQMTIYHPgq-qsGIFKSIrFSSKEKFPSIEVVKFGRNSnmCQYTFQDKQVSRIQFVLQPFKQFNSSvLSFEIKNMS 91  Mus musculus
Q96CG3        13 VTCLQMTVYHPgqlqcGIFQSI-SFNREKLPSSEVVKFGRNSniCHYTFQDKQVSRVQFSLQLFKKFNSSvLSFEIKNMS 91  human
6L9U_A        13 VTCLQMTIYHPgq-qsGIFKSIrFCSKEKFPSIEVVKFGRNSnmCQYTFQDKQVSRIQFVLQPFKQFNSSvLSFEIKNMS 91  Mus musculus
XP_420645     80 ATCLHMTFYHPcqqdkMMFRCLnFCKREQVRADEMAKFGRDSnvCHYNLVDTRVSRIQFSLQFYRKLNSSeFCFEIKNMS 159 chicken
Q2MHQ9        14 ISCLTLTLYHPnhqdqKLFRGInFSRKEEIKADAVVAFGRDYnvCRYPLLSNRVSRIQFNLQLFKHFNCStSTFEIKNLS 93  African clawed ...
XP_007895196  17 ITCLNIHIYHPq---pTVFQSLtLDKKLKFRTDEVLKFGRDSniCNFPLIDKRASRIQFSIQAVRFLESTeLCFEIKNLS 93  elephant shark
XP_014348474  17 PPLLHVHMLHPdeeetQVFCSLnFGQKHLYKSHEMLTFGRLDs-CNVKLHHHRASRLQFQIRAFCNRSSSqLCFELKNLS 95  coelacanth
RXM27820      13 LTCLRITVHHPlheikNVFQLIhFNKREKHMVEDPLKVGRDTksCHISLYDLRVSRVQFSIQAFRHFNSSkLFFEIKNLS 92  sterlet
Feature 1          #                                                    
4YM4_A        83 KKTNLIVDSRELGYLNKXDLPyRCXVRFGEYQFLXEKEDGESlEFFETQFILSPR 137 Homo sapiens
4ZGI_A        83 KKTNLIVDSRELGYLNKXDLPyRCXVRFGEYQFLXEKEDGESlEFFETQFILSPR 137 Homo sapiens
6L9V_A        92 KKTSLMVDNQELGYLNKMDLPyKCMLRFGEYQFLLQKEDGESvESFETQFIMSSR 146 Mus musculus
6L9W_A        92 KKTSLMVDNQELGYLNKMDLPyKCMLRFGEYQFLLQKEDGESvESFETQFIMSSR 146 Mus musculus
Q96CG3        92 KKTNLIVDSRELGYLNKMDLPyRCMVRFGEYQFLMEKEDGESlEFFETQFILSPR 146 human
6L9U_A        92 KKTSLMVDNQELGYLNKMDLPyKCMLRFGEYQFLLQKEDGESvESFETQFIMSSR 146 Mus musculus
XP_420645    160 KKTKLTVDQTELGYLNKVDLPwKCIICFGDYQILAEIQEGEAmDYFETHLHLAKV 214 chicken
Q2MHQ9        94 KKNKLYVDNLELDYLNKIELPkKCMIRFGDFQILAEIDEGDSdEKFEICCEKSHV 148 African clawed frog
XP_007895196  94 LKTKISVDFAILNHLNKVELLrRGLLRFGEYQLCLEKEDGESrEQFEILFKLSLV 148 elephant shark
XP_014348474  96 EKTPLYLNGEELGFLQKAELLgKVTLLFSEFRFFLEVEEGETaKKFEVVFLKSPT 150 coelacanth
RXM27820      93 KKGKLIVNNTELEHLNKVELPkKALVRFAEFQLLVEKEDGEStESFDTFFELVRT 147 sterlet

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