3LW1,1YWT


Conserved Protein Domain Family
14-3-3_sigma

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cd10019: 14-3-3_sigma 
Click on image for an interactive view with Cn3D
14-3-3 sigma, an isoform of 14-3-3 protein
14-3-3 protein sigma isoform, also known as stratifin or human mammary epithelial marker (HME) 1, has been most directly linked to tumor development. In humans, it is expressed by the SFN gene, strictly in stratified squamous epithelial cells in response to DNA damage where it is transcriptionally induced in a p53-dependent manner, subsequently causing cell-cycle arrest at the G2/M checkpoint. Up-regulation and down-regulation of 14-3-3 sigma expression have both been described in tumors. For example, in human breast cancer, 14-3-3 sigma is predominantly down-regulated by CpG methylation, acting as both a tumor suppressor and a prognostic indicator, while in human scirrhous-type gastric carcinoma (SGC), it is up-regulated and may play an important role in SGC carcinogenesis and progression. Loss of 14-3-3 sigma expression sensitizes tumor cells to treatment with conventional cytostatic drugs, making this protein an attractive therapeutic target. 14-3-3 domains are an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including yeast, protozoa and mammalian cells.
Statistics
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PSSM-Id: 206756
Aligned: 3 rows
Threshold Bit Score: 476.059
Created: 12-Jul-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:14-3-3 sigma is the only strictly homodimeric member of 14-3-3 family of proteins.
  • Structure:1YWT: Human 14-3-3 sigma domain homodimer; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #   #  ## #  #      #                                #  #   #              #
3LW1_A         6 MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSXEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEegsEEKGPE 85  human
1YWT_A         1 MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEegsEEKGPE 80  human
XP_002194418   1 MARNHQVQKAKLAEQAERYEDMADFMKAVVEHGDELSNEERNLLSVAYKNVVGCQRSAWRVISSIEHKTEEg--DDKAQV 78  Taeniopygia gut...
Feature 1        # ##  ##  #                                                                     
3LW1_A        86 VREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKK 165 human
1YWT_A        81 VREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKK 160 human
XP_002194418  79 VNEYREKVEQELNAVCNNVLGLLDKYLIKKDSDTESKVFYLKMKGDYFRYLAEVASGDDRLSTIEKAQEAYQEAMDISKK 158 Taeniopygia gut...
Feature 1                                                                                        
3LW1_A       166 EMpPTNPIRLGLALNFSVFHYEIaNSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTadnAGEEGG 245 human
1YWT_A       161 EMpPTNPIRLGLALNFSVFHYEIaNSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTadnAGEEGG 240 human
XP_002194418 159 EMqPTNPIRLGLALNFSVFHYEIaNAPEQAISLAKTTFDEAMGDLHTLSEDSYKDSTLIMQLLRDNLTLWTaecAGEDGG 238 Taeniopygia gut...
Feature 1          
3LW1_A       246 EA 247 human
1YWT_A       241 EA 242 human
XP_002194418 239 EA 240 Taeniopygia guttata

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