1KZH


Conserved Protein Domain Family
Pyrophosphate_PFK
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cd00765: Pyrophosphate_PFK 
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Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Links
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Statistics
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PSSM-Id: 238390
Aligned: 3 rows
Threshold Bit Score: 993.223
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1KZH_A      1 MNTSLFKQERQKYIPKLPNILKKdfnnislVYGENTEAIQDRQALKEFFKNTYGLPIIsfteges--------slsfska 72  Borrelia burgdorferi
NP_218981   1 MSISLLQQERHRYLPKVPDLLRGdfrrvcaRRGLSTTAVADYDALRSLFARTYGQPLVnfvnaseknedspmetapeprg 80  Treponema pallidum
NP_172664  27 SVYSEVQSSRINNTLPLPSVLKGaf---kiVEGPASSAAGNPDEIAKLFPGLYGQPSVavvpdqd--------apssapk 95  Arabidopsis thaliana

Feature 1              #                               #                               #      
1KZH_A     73 LNIGIILSGGPAPGGHNVISGVFDAIKKFNpnSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE 152 Borrelia burgdorferi
NP_218981  81 LRVAIVLSGGQAPGGHNVIAGLFDGLKRWHadSVLIGFLGGPAGVLSGDHIEICADRVDAYRNTGGFDLIGSGRTKIESE 160 Treponema pallidum
NP_172664  96 LKIGVVLSGGQAPGGHNVISGLFDYLQERAkgSTFYGFKGGPAGIMKCKYVELNAEYIQPYRNQGGFDMICSGRDKIETP 175 Arabidopsis thaliana

Feature 1                            ### ##                      # # #                        
1KZH_A    153 EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVPKTIDADLRNDHIEISFGFDSATKIYSELIG 232 Borrelia burgdorferi
NP_218981 161 SQFAAAAQTVTRMALDALVVVGGDDSNTNAALLAEHFVNSGISTKVIGVPKTIDGDLKNEAIETSFGFDTATKTYSELIG 240 Treponema pallidum
NP_172664 176 DQFKQAEETAKKLDLDGLVVIGGDDSNTNACLLAENFRSKNLKTRVIGCPKTIDGDLKCKEVPTSFGFDTACKIYSEMIG 255 Arabidopsis thaliana

Feature 1                       ###                                                          #
1KZH_A    233 NLCRDAMSTKKYWHFVKLMGRSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNGDNFGVVIVPE 312 Borrelia burgdorferi
NP_218981 241 NIARDACSARKYWHFIKLMGRSASHIALECALKTQPNVCLISEEVAAQSLTLAQIVQSLCDTIATRAQHGEHFGIVLVPE 320 Treponema pallidum
NP_172664 256 NVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVSAQKQTLKNVTDYMVDVICKRAELGYNYGVILIPE 335 Arabidopsis thaliana

Feature 1                                                                                     
1KZH_A    313 GLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFVAklsdymkgvylslplfiqfeliKSILERDPHGNFNVSRV 392 Borrelia burgdorferi
NP_218981 321 GLIEFIPEMKALITELNEVMARRAQEFEALDTPDAQRVWIEqalsasarav--fnalpaeistQLLADRDPHGNVQVSRI 398 Treponema pallidum
NP_172664 336 GLIDFIPEVQELIAELNEILANEVVDENGLWKKKLTEQSLKlfdllp-----------eaiqeQLMLERDPHGNVQVAKI 404 Arabidopsis thaliana

Feature 1                                        #  #                                         
1KZH_A    393 PTEKLFIEMIQSRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVVLILNGLTGYMSCIKNLnlkP 472 Borrelia burgdorferi
NP_218981 399 DTERLLILQVTERLAQMKQEGTYTGVFSSIAHFFGYEGRCAFPSNFDADYCYTLGLTACLLAVHRFTGYVASVRNLtssV 478 Treponema pallidum
NP_172664 405 ETEKMLIQMVETELEKRKQAGAYKGQFMGQSHFFGYEGRCGLPTNFDATYCYALGYGAGVLLNSGKTGLISSVGNLaapV 484 Arabidopsis thaliana

Feature 1                                                                                     
1KZH_A    473 TDWIAGGVPLTMLMNMEERYGEKKPVIKKALVDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGsseiVDEITETLKLE 552 Borrelia burgdorferi
NP_218981 479 AEWAVGGVPLTMLMNMERRHGSQKPVIKKALVDLEGMPFRVFSRRRASWALKTSYVYPGAVQYYGppavCDEPSVTIRLE 558 Treponema pallidum
NP_172664 485 EEWTVGGTALTALMDVERRHGKFKPVIKKAMVELEGAPFKKFASLREEWALKNRYISPGPIQFTGp--gSDSLSHTLLLE 562 Arabidopsis thaliana

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