1M55,4ZO0


Conserved Protein Domain Family
Rep_N

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pfam08724: Rep_N 
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Rep protein catalytic domain like
Adeno-associated virus (AAV) Replication (Rep) protein is essential for viral replication and integration. The catalytic domain has DNA binding and endonuclease activity.
Statistics
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PSSM-Id: 312303
Aligned: 11 rows
Threshold Bit Score: 227.699
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M55_A     4 FYEVIVRVPFDVEEHLPGISDSFVDWVTGQIWElpPESDLNLTLVEQPQ---LTVADRIRRVFLYEWNKFSKQeS----- 75 
Q6JL80     4 FYEVIVRVPFDVEEHLPGISDNFVDWVTGQIWElpPESDLNLTLIEQPQ---LTVADRIRRVFLYEWNKFSKQ-Es---- 75  Bovine adeno-associ...
Q7TG44     4 YYEVIVQLPNDVESQVPGISDSFVNWITSREWTlpEDADWDLDQVDQVQ---LTLGDKIQREIRTHWGTMAKEpDf---- 76  Avian adeno-associa...
Q9WKM1     3 LFRGVLQ-----------VSSNVLDCANDNWWC----SLLDLDTSDWEP---LTHTNRLMAIYLSSVASKLDFtGgplag 64  Human parvovirus B19
Q88271     3 MYRGVIQ-----------VNANFTDFANDNWWC----CFFQLDVDDWPE---LRGPERLMAHYICKVAALLDTpSgpflg 64  Simian parvovirus
Q9J0X5     3 MFRGVVH-----------VSANFINFVNDNWWC----CFYQLEEDDWPR---LQGWERLIAHLIVKVAGEFAVpGgstlg 64  Pig-tailed macaque ...
Q9J0X7     3 MFRGVIQ-----------LTANITDFANDSWWC----SFLQLDSDDWPE---LRGVERLVAIFICKVAAVLDNpSgtslg 64  Rhesus macaque parv...
Q9WSZ6    17 YIMLTIKGPVEWEAEIPGISTDFFCKFSNv----pVPHFRDMHSPGAPDikwITACTKMIDVILNYWNNKTAVpTp---- 88  Human herpesvirus 6...
AGG56527  14 FYEVIIRLPSDIDQDVPGLSLNFVEWLSTGVWE--PTGIWNMEHVNLPM---VTLAEKIKNIFIQRWNQFNQD-Et---- 83 
Q8JQG1     4 FYEIVIKVPSDLDEHLPGISDSFVNWVAEKEWElpPDSDMDLNLIEQAP---LTVAEKLQRDFLVQWRRVSKApEa---- 76  Adeno-associated vi...
4ZO0_A     7 FYEIVIKVPSDLDEHLPGISDSFVNWVAEKEWElpPDSDMDLNLIEQAP---LTVAEKLQRDFLTEWRRVSKApEa---- 79 
1M55_A    76 -KFFVQFEKG--SEYFHLHTLVETSGISSMVLGRYVSQIRAQLVKVVFQGIEPQINDWVAITKVKK--GGANKVVDSGYI 150
Q6JL80    76 -KFFVQFEKG--SEYFHLHTLVETSGISSMVLGRYVSQIRAQLVKVVFQNIEPRINDWVAITKVKK--GGANKVVDSGYI 150 Bovine adeno-associ...
Q7TG44    77 -HYFIQLEQG--EVFFHLHVLLETCSVKPMVLGRYIRHIQQKIVSKVYCATSLRWKDGCVVTKTKNf-GGANKVRAESYI 152 Avian adeno-associa...
Q9WKM1    65 cLYFFQVECNkfEEGYHIHVVIGGPGLNPRNL---TVCVEGLFNNVLYHLVTENVKLKFLPGMTTK---GKYFRDGEQFI 138 Human parvovirus B19
Q88271    65 cKYFLQVEGNhfDNGFHIHVVIGGPFLTPRNV---CSAVEGGFNKVLADFTSPTITVQFKPAVSKK---GKYHRDGFDFV 138 Simian parvovirus
Q9J0X5    65 lQYFLQAEHNhfDEGFHVHVVVGGPFVTPRNV---CNIVETGFNKVLRELTEPTYEVSFKPAISKK---GKYARDGFDFV 138 Pig-tailed macaque ...
Q9J0X7    65 cKYFLQAEGNhyDAGFHVHIVIGGPFINARNV---CNAVETTFNKVLGDLTDPSMSVQFKPAVSKK---GEYYRDGFDFV 138 Rhesus macaque parv...
Q9WSZ6    89 aKWYAQAENK--AGRPSLTLLIALDGIPTATIGKHTTEIRGVLIKDFFDGNAPKIDDWCTYAKTKKn-GGGTQVFSLSYI 165 Human herpesvirus 6...
AGG56527  84 -DFFFQLEEG--SEYIHLHCCIAQGNVRSFVLGRYMSQIKDSIIRDVYEGKQIKIPDWFAITKTKR--GGQNKTVTAAYI 158
Q8JQG1    77 -LFFVQFEKG--ESYFHLHVLVETTGVKSMVLGRFLSQIREKLVQTIYRGVEPTLPNWFAVTKTRNgaGGGNKVVDECYI 153 Adeno-associated vi...
4ZO0_A    80 -LFFVQFEKG--ESYFHMHVLVETTGVKSMVLGRFLSQIREKLIQRIYRGIEPTLPNWFAVTKTRNgaGGGNKVVDESYI 156
1M55_A   151 PAYLLPKVQPELQWAWTNLDEYKLAALNLEERKRLVAQF 189
Q6JL80   151 PAYLLPKVQPELQWAWTNLEEYKLAALNLEERKRLVAQF 189 Bovine adeno-associated virus
Q7TG44   153 PAYLIPKQQPEVQWAWTNVPEYIKACLHRELRASLARLH 191 Avian adeno-associated virus ATCC VR-865
Q9WKM1   139 ENYLMKKIPLNVVWCVTNIDGYIDTCISATFRKGACHAK 177 Human parvovirus B19
Q88271   139 TYYLMPKLYPNVIYSVTNLEEYQYVCNSLCYRRTMHKRQ 177 Simian parvovirus
Q9J0X5   139 TNYLMPKLYPNVVYSVTNFSEYEYVCNSLAYRRNMHKKA 177 Pig-tailed macaque parvovirus
Q9J0X7   139 TNYLMPKLYPNVIYSVTNLEEYQYVCNSLCYRKNMHKQH 177 Rhesus macaque parvovirus
Q9WSZ6   166 PFALLQIIRPQFQWAWTNINELGDVCDEI-HRKHIISHF 203 Human herpesvirus 6 strain Z29
AGG56527 159 LHYLIPKKQPELQWAFTNMPLFTAAALCLQKRQELLDAF 197
Q8JQG1   154 PNYLLPKTQPELQWAWTNMEEYISACLNLAERKRLVAQH 192 Adeno-associated virus - 7
4ZO0_A   157 PNYLLPKTQPELQWAWTNMEQYLSACLNLTERKRLVAQH 195
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