2A65,3F3C,3F4J,3F48,2QJU,3GWU,3GJD


Conserved Protein Domain Family
LeuT-like_sbd

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cd10333: LeuT-like_sbd 
Click on image for an interactive view with Cn3D
Aquifex aeolicus LeuT and related proteins; solute binding domain
LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.
Statistics
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PSSM-Id: 271365
Aligned: 19 rows
Threshold Bit Score: 571.181
Created: 3-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
  • Structure:2A65: Aquifex aeolicus LeuT binds the Na ion designated Na2.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #  #                                                             
2A65_A         5 REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGt-TPAIFYL 83  Aquifex aeolicu...
ADY60943       4 RENWGSRIGVILAVAGSAVGLGNFLRFPGQAAQNGGGAFMIPYFVSLLLLGIPLCWAEWTMGRYGGTRGFHs-APGTFSV 82  Planctomyces br...
YP_002248649  10 REKWQSRIGLILATAGNAVGLGNILRFPSKAALYGGGAFMLPYFIAFLLMGLPLMIIEWVIGRYAGKHGHGs-MTGILGL 88  Thermodesulfovi...
ADG90693       7 REAWATRIGLILSMAGNAVGLGNFWRFPRLLAANGGGAFMIPYFIALLLLGIPLMWVEWATGRLGGKYGHGtlGPMFYIM 86  Thermosphaera a...
YP_001411080   4 REHWGSKIGLILAMAGNAIGLGNFWRFPYQAAKNGGGAFMIPYFIAFLFMGIPLLIIEWAQGRYGGKYGHGtlGPMIYLQ 83  Fervidobacteriu...
CBH21765       6 RGSWGSKIGLILAMAGNAVGLGNFWRFPYQAASNGGGAFMLPYFAALIILGLPLMLSEWNLGRYGGKYGHGtlGPMVYLQ 85  Clostridium sti...
ADD03533       5 RENWGTKIGLILAMAGNAIGLGNFWRFPYQVAKNGGGAFMLPYFAALLLLGIPLIYVEWMQGRYGGKYGHGtiGCMTYLQ 84  Thermoanaerobac...
AEE50191       6 TESWGSRVGLVLAMAGNAVGLGNFLRFPVQAIQNGGGTFIIPYLVCFLLMGIPLLFVEWSMGRFGGKYGHHs-TPFILDS 84  Haliscomenobact...
YP_798202      7 KENWKSRTGLILTVASGAIGLGNFIRFPGQAVANGGGAFMVPYIISFILVGIPVCITEWIMGRMGGRTGHS--APFLFKS 84  Leptospira borg...
ABZ94172      10 QEGWASRVGLILAVASGAIGLGNFLRFPGQAAQNGGGAFMVPYIISFLILGIPVCLAEWTMGRMGGKHGHS--TPFIFRE 87  Leptospira bifl...
Feature 1                                                                                        
2A65_A        84 Lwr-------nRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGlvpepppnatdpdsilrpFKEFLYSYIgvpk 156 Aquifex aeolicu...
ADY60943      83 Icr-------nPRARYLGAIALLIPLIIYMYYVVIEAWCLGYAISYLDGslalgns-----peayekHFNKFVGLNgdga 150 Planctomyces br...
YP_002248649  89 Ffn------hsSWARILGSIGVAIPVLICMYYIYIESWTLGFAFMSLFKqmpvpikta-npqeavkpYVEFFRTYTn--- 158 Thermodesulfovi...
ADG90693      87 AresvkprkalIFAVIGGMIAFSVTTLLNSYYIHVIGWTAAYSIYSATGayy------------gvdTVNFFFDHIk--- 151 Thermosphaera a...
YP_001411080  84 AkesvghkfakVLGALAGAIALSVVILLNSYYNHVIGWTLGYSFETAVGkymd----------ksidTAGYFVGYIq--- 150 Fervidobacteriu...
CBH21765      86 AregakpktalILGAIAGGLAFAVTLLVNSYYNHLIGWTLGFAVSSFTGaymd----------qsqsTADFFVGYIq--- 152 Clostridium sti...
ADD03533      85 AkeklghssaaIIGALVGMLVFSVTVLVNAYYTQITGWTLGYSYLSLTGgymg----------tarsTAEVFGSYIq--- 151 Thermoanaerobac...
AEE50191      85 Msk-------qAFWKYIGVFGIFTNLAVAAYYCYLESWTLGYIWHSVAGtfdgq---------trdeVANFFTNYTs--- 145 Haliscomenobact...
YP_798202     85 Fls-------gFPLRIVGAIGITIPILIYIYYVFIEAWCLAYSFEFLTGqirlnpngn-ayqsqiieAAGNYYLDItgar 156 Leptospira borg...
ABZ94172      88 Ylk-------gFPLRLSGTIGVMIYVYYVFIESWCLAYAYYFLTGQMSLsattqa-------gmtkeASTFFMNLTgase 153 Leptospira bifl...
Feature 1                                                                                        
2A65_A       157 gdepilkPSLFAYIVFLITMFINVSILirGISKGIERFAKIAMPTLFILAVFLVIRVFLLetp-----ngtAADGLNFLW 231 Aquifex aeolicu...
ADY60943     151 ---lfgrSGGEFLGVLIFTFAVNFFFIyrGVTKGIEAFCRVAMPLMVVLAIVVLIRVLTLgaplpdepdrtVVNGLGAMW 227 Planctomyces br...
YP_002248649 159 -------PSMIAYIFLLITIAINWFILqkGVAKGIEITAKIGMPAIIIFGILLGIISLSArd-------waGLEGLKFIY 224 Thermodesulfovi...
ADG90693     152 -------NFQMVMVTWLIPMILLFIAAfrGVSKGIEAFNKVMMPLLYVFAVVLAIRSITIgspir--pdwsSFAGLNYIW 222 Thermosphaera a...
YP_001411080 151 -------SPFRVLIFWIITLAILYYITsnGVNKGLERLAIIAMPAIYIFAIILLVRALTLgspvn--pewnPIKGLDFLW 221 Fervidobacteriu...
CBH21765     153 ------dPKMVFTFWIIALVGLSFAVMr-GVEKGIEAWAKLMMPVLYVFGIVLAIRSLTIgspvn--pewsSLKGLNFIW 223 Clostridium sti...
ADD03533     152 -------NPSLSITFWVITLALLAFALsrGVQKGIEAWAKVMMPLLYVFGFILIIRTLTLgspvn--pdwsPIKGLDYIW 222 Thermoanaerobac...
AEE50191     146 ------lSDAQPIIFWVICLLLNTWILsrGLSGGVEKVAKIGMPLLILFGVILAIRGVSLqpgtn-nalyaGTDGLNYLW 218 Haliscomenobact...
YP_798202    157 a--ngdaISGKIFYTTLTCFILNFALVyrGISKGIETFAKIAVPFMLVCSAVILVRVLTLd---------nIEIGLGKMW 225 Leptospira borg...
ABZ94172     154 ---ngssFHSPIIVFFLICVLFNFFLVyrGLSKGLEAFAKIAMPLMGICATIILIRVLTIp---------gIEKGLAVMW 221 Leptospira bifl...
Feature 1                                                                                        
2A65_A       232 TPDFekl--kdPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGva 309 Aquifex aeolicu...
ADY60943     228 NPKFekl--anPQTWLAASGQIFFSLSVGFGVIINYASYLRRKDDVALSGLTATSVNEFFEVCLGGLITLPAAFIFLGa- 304 Planctomyces br...
YP_002248649 225 NLNFsgi--kdPTVWIEASGQIFFTLSLGMGAIAVYASYVKPKEDVVKAGFWTAGINEFVEVIIGASIAIPAAFAMFSav 302 Thermodesulfovi...
ADG90693     223 KPDFealsknfWVISLAAAGKIFFTLSLGMGIIQNYASYVRKGDDIALSALTTASLNEFAEVILGGSIAIPIAYAYLGp- 301 Thermosphaera a...
YP_001411080 222 SPRWne---lnWSATLAAAGQIFFTLSLGMGIIQNYASYMRDEDDIVTSAVATASLNEFAEVILAGTIVIPIAFTFLG-- 296 Fervidobacteriu...
CBH21765     224 NPDFst---ltWRSALAAAGQIFFTLSIGMGIICNYASYLKPDDDVVVSSIATISLNEFAEIVLGGSIVIPIAYAFLG-- 298 Clostridium sti...
ADD03533     223 SPKWse---lnWQSALAAAGQIFFTLSLGMGIIQNYASYLKPDEDIVLSATTTVFLNEFAEVILGGTIAIPIAYTFLG-- 297 Thermoanaerobac...
AEE50191     219 TPDFsti--wsPKVWLAAAGQIFFTLSVGMGSIQCYSSYLRSRDDVALNAMSAGWMNEFVEVCLGGAIVIPITVGYFGid 296 Haliscomenobact...
YP_798202    226 NPDWsal--lkSEVWIAAAGQIFFTLSAGFGIALVFSSYLKRDNDVVLSSLSAASLNEFVEVAIGGMITIPVSFLFLGa- 302 Leptospira borg...
ABZ94172     222 NPDWskl--tePKVWISAAGQIFFSLSTGFGIALVFSSFLKKKDDVVLSSLSSASINEFAEVVFGGMITIPVAFLFLGm- 298 Leptospira bifl...
Feature 1                                                    #  ##                               
2A65_A       310 n-avAIAKAGAFNLGFITLPAIFSQTA--GGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELklsRKHAVLWTAAIV 386 Aquifex aeolicu...
ADY60943     305 ----ASQEMGTFSLGFVALPNVFANMP--GGQLFGFFWFFMLFIAAITSSLSMLQPVIAFFEEGLg-lKRHAAAAILGLL 377 Planctomyces br...
YP_002248649 303 a-ipELAKEGTFRLGFMTMPAVLMNLP--LGWIASFIWFLLLFLAALTSSLALIQPIIALFEDEMkweHTKAVSVSMILV 379 Thermodesulfovi...
ADG90693     302 ----DVVRSGSLGLAFMALPNVFTSMGe-VGRFFGTIWFLLLFFAGWTSAIAMYNYLTALLEEDLkinRKIGAVIVFLIY 376 Thermosphaera a...
YP_001411080 297 ----AEGLKSGVGLSFIALPNVFRNMA--GGQIFGTFWFLLLFFAGITSSIAMFNYLTAFLEEEFgveRKKGSLFVFLMY 370 Fervidobacteriu...
CBH21765     299 ----PDGIGAGVGLSFIALPNVFRTMA--GGQFFGGLWFLLLFFAGFTSAIAMYNYLTALVEEDLgipRKTAAWIIFAAY 372 Clostridium sti...
ADD03533     298 ----PEGVASGVGLSFIALPNVFRMMT--GGQFFGALWFLVLFVAGFTSAIAMYNYLITILQEDLnvpRKIGAVVVFGFY 371 Thermoanaerobac...
AEE50191     297 gmleLVNKVGGLGLGFRTLPFLFQQWGpfLAIAASVMWFGLLFFAGITSSLAMGTPCMGFLQDEFgwkRENAAWAFGATV 376 Haliscomenobact...
YP_798202    303 ----SINDFGTFGMGFIALPSVFSLMP--GGEWFGAIWFFVLFLAAITSSVTMLQPGIIFLEEAFg-iRRHTSTFILFVF 375 Leptospira borg...
ABZ94172     299 ----QVTSFGTFGMGFIALPSVFGMMP--GGDFFGGLWFLVLFLAAITSSVTMLQPGILFLEEGFr-mGRRKSSLMLFLF 371 Leptospira bifl...
Feature 1                                                                                        
2A65_A       387 FFSAHLVMFl--------nKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINr-GGIIKVPRIYYYVMRYITP 457 Aquifex aeolicu...
ADY60943     378 SAIGALFVAyfs----gglVALDTLDFWVGTTTIFVLGLIQSIVYGWIFGIKRGHAELHe-GAHIQIPIFVQYMLKYVTP 452 Planctomyces br...
YP_002248649 380 ITGAHFSAFm--------pNFIDELDFWAGCVMLLIFGLIEIIVFIWIFGINNFYNELIq-NTSIKLPRAFVYVIAFISP 450 Thermodesulfovi...
ADG90693     377 LMLGLPVALdp------tlTYFAELDNWVGSYLLVVLGLFDVIVAVWLFKPNNLWKELHe-GALIKVPTFFKYVLMTLTP 449 Thermosphaera a...
YP_001411080 371 IIGGLPVALepiltktadlMYLTELDNWVGTYFLVLLGLIEVIAAVWLFKAKGLEEINKg-SYWKIPMWFYKLIMSFITP 449 Fervidobacteriu...
CBH21765     373 VVVGLPVGLeqiinktadlAYFTEIDNWVGSYLLLVLGLIEIIVVAFLMGEKALTEINKg-GIWQMPKWFYTVFMRGLTP 451 Clostridium sti...
ADD03533     372 ILVGLPSALepiltrtselIFLTELDNWVGNYFLVIVGLIEAVVVGWLFGEKKAKEEINrgSYWKVPSGFFNVMVKFITP 451 Thermoanaerobac...
AEE50191     377 GILGLPTVLff------nyGVFDEYDHWAGTVSLVVFAFFEIILFAWIFGMKKGWEEITr-GADIKVPIIFKYIIQYVTP 449 Haliscomenobact...
YP_798202    376 TGCLCFPILyfn----qnfQALELADFWVGTILIFILASIQIFLFGWKIGAKKGIEDGNe-GSHFELPRFFWFVIQYITP 450 Leptospira borg...
ABZ94172     372 TFVLCLPIIyfn----kdfAALDIADFYIGTIMIYILASIQIFVYVFKIGVDRGEKEANe-GSLIPFPKPIKFVLKYITP 446 Leptospira bifl...
Feature 1                                                                                     
2A65_A       458 AFLAVLLVVWARe-YIPKIMeet----------------------hwTVWITRFYIIGLFLFLTFLVFLAERRRNHE 511 Aquifex aeolicus VF5
ADY60943     453 VYLLVVFAMFCYh-NVPGYLtsmn--------------------enpVAKASIVFIGVVFTFLLILVHIAGIRWIKE 508 Planctomyces brasi...
YP_002248649 451 VFLSFILYFWVIk-DFGNLItag----------------------esTKIIARLFILAFLAFLSFIAVKSRKIILRD 504 Thermodesulfovibri...
ADG90693     450 LYIIILLIGTTId-YYNQGIfaq---------------------sdpLIVQARIAIIIILVLGAIETYLAISRKYRE 504 Thermosphaera aggr...
YP_001411080 450 AFIIILLVFSTId-YAKNGYfklipdfv-----------kdnsvlipWVIAARIVLIVIFISSFILTYRSISKKLET 514 Fervidobacterium n...
CBH21765     452 AALVIVLVFSTLd-YIKAGYfkfvpdfv-----------agtpvlipWVNAARLVILIVVAAGAMQSYKSIKNKYGK 516 Clostridium stickl...
ADD03533     452 LSIAVLLIFSTKs-YIDDGYfkwipsfv-----------ektpelipWVQGARLLLLTILIIGFAETYYTIQKKFGN 516 Thermoanaerobacter...
AEE50191     450 VILGWVLIASMPanWDKIMNtglyaqiaaatd---pavianlektimYQNIARIGLLALWIGIAVLVYIAYRKRLRE 523 Haliscomenobacter ...
YP_798202    451 VFLIVVFIAFLIq-NLPGHFermsvdamisqaiargtsvevartkalVSKSVFFGILIVFSLIVLLVHYALKYKEKR 526 Leptospira borgpet...
ABZ94172     447 WFLFFIFVSFCYm-NLPEYLdkmnpevmglla---enkgqnvedaktKAVIARSVVIGLLLIYGFIYFLVSKALEHK 519 Leptospira biflexa...

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