223997514 12 ITPPRMKCTDVPQFTALQMAASAfrnddklhLKHLLadafrcqglmavhttsndfemgfregngrsalgggggglddvsa 91 115479643 72 sTRGAVEKDPIKLWERYVEWLYQ--------HKELG-------------------------------------------- 99 115476914 71 LAHGAVDKDPIRLWNRYVEWLYQ--------HKQLG-------------------------------------------- 98 224063299 67 PKQLGLEKDPNSLWRRYVDWLYQ--------HKELG-------------------------------------------- 94 225459126 72 pKKKGLEKDPGALWRRYVDWLYQ--------HKELG-------------------------------------------- 99 225459128 72 pKKKGLEKDPGALWRRYVDWLYQ--------HKELG-------------------------------------------- 99 242049530 65 sGVRAVEKDPIKLWERYVEWLYQ--------HKELG-------------------------------------------- 92 255545916 67 kPEQGLEKDPNSLWRRYTEWLYQ--------HKELG-------------------------------------------- 94 302773786 1 -------MEASALWERYVEWLYQ--------HKELG-------------------------------------------- 21 302793418 1 MEKPALEMEASALWERYVEWLYQ--------HKELG-------------------------------------------- 28
223997514 92 vaagrtsgsrqrrIILDYSRQHVTGETMELLFDLADRMglTERIHDMRSGYNVNFTEGRAVMHHVLRLPKGYD--FKArh 169 115479643 100 -------------LFVDVSRMGFTEEFLRRMEPRMQRA--FAAMRELEKGAIANPDEGRMVGHYWLRDPGLAPnsFLR-- 162 115476914 99 -------------LFVDVSRIGFTEEFLRRMEAPMGRA--FAAMRELEKGAIANPDEGRMVGHYWLRNPALAPnsFLR-- 161 224063299 95 -------------LYLDVSRIGFTDEFVSEMEPRFHKA--FKDMEELEKGAIANPDEGRMVGHYWLRNSTLAPksFLK-- 157 225459126 100 -------------LFLDVSRIGFSEEFVEEMEPRFQAA--FRAMQELEKGAIANPDEGRMVGHYWLRSSKLAPnpFLK-- 162 225459128 100 -------------LFLDVSRIGFSEEFVEEMEPRFQAA--FRAMQELEKGAIANPDEGRMVGHYWLRSSKLAPnpFLK-- 162 242049530 93 -------------LFVDVSRMGFTDDFLQQMEPRMQQA--FAAMRELEKGAIANPDEGRMVGHYWLRDPALAPnsFLR-- 155 255545916 95 -------------LYLDVSRIGFTDNFVEEMDPRFQKA--FKDMEELEKGAIANPDEGRMVGHYWLRNPGLAPkaFLK-- 157 302773786 22 -------------LYVDVSRMGFSDGFVIAMEERFAKA--FKDMEKLEGGGISNPDEKRMVGHYWLRNSELAPsyYLK-- 84 302793418 29 -------------LYVDVSRMGFSDGFVKAMEERFAKA--FKDMEKLEGGDISNPDEKRMVGHYWLRNSELAPsyYLK-- 91
223997514 170 pqgdeilGQVHSALDRVETFSEDVREGRIR--GCTGKKFKNIVCIGIGGAHSGPEAIYEALRGDADASkaaegrgaKLLF 247 115479643 163 -------TKIETTLDRILAFSQDVVSGKIKppSSPAGRFTQILSIGIGGSALGPQFVSEALAPDNPPL--------KIRF 227 115476914 162 -------DKIETTLERILAFASDVISAKIRppSSPAGRFTQILSIGIGGSSLGPQFVAEALAPDNPPL--------MIRF 226 224063299 158 -------TQIDKALDAVCDFADQVVSGKIK--TPDGGRFTQILSVGIGGSALGPQFVAEALAPDNPPL--------KIRF 220 225459126 163 -------LQIENTLEAVCKFAEDVVSGKIKppSSPEGRFTHVLSVGIGGSALGPQFVAEALAPDNPPL--------KIRF 227 225459128 163 -------LQIENTLEAVCKFAEDVVSGKIKppSSPEGRFTHVLSVGIGGSALGPQFVAEALAPDNPPL--------KIRF 227 242049530 156 -------NKIETALDSILAFSQDVVSGKIQ---SPAGRFTSILSIGIGGSALGPQFVAEALAPDNPPL--------KIRF 217 255545916 158 -------QQIDKALDAVCQFAGDVVSGKIKppNSPEGRFTQILSVGIGGSALGPQFVAEALAPDNPPL--------KIRF 222 302773786 85 -------KQIDETLEGVKAFAGDVISGKIKppPCPAGKFTHVLSIGIGGSALGPQFVAEALAPDNPPL--------EIRF 149 302793418 92 -------KQIDETLEGVKAFAGDVISGKIKppPCPAGKFTHVLSIGIGGSALGPQFVAEALAPDNPPL--------EIRF 156
223997514 248 IANIDPVDFDLCTRELNPD--ETLFIVNSKSFETAETTQNARTARRWLVRNicaksengnsgeglseADVVSRHFCAVT- 324 115479643 228 IDNTDPAGIDHQIAQLGPElaSTLVIVISKSGGTPETRNGLLEVQKAFRDA----------------GLDFSKQGVAVTq 291 115476914 227 IDNTDPAGIDHQIAQLGPElaSTLVIVISKSGGTPETRNGLLEVQKAFRDA----------------GLEFSKQGVAITq 290 224063299 221 IDNTDPAGIDHQIAQLGPElaSTLVIVISKSGGTPETRNGLLEVQQAFREA----------------GLDFAKQGVAITq 284 225459126 228 IDNTDPAGIDHQIAQLGPElaSTIVIVISKSGGTPETRNGLLEVQKAFREA----------------GLDFAKQGVAITq 291 225459128 228 IDNTDPAGIDHQIAQLGPElaSTIVIVISKSGGTPETRNGLLEVQKAFREA----------------GLDFAKQGVAITq 291 242049530 218 IDNTDPAGIDHQIAQLGPElaTTLVIVISKSGGTPETRNGLLEVQKAFRDA----------------GLQFSKQGVAITq 281 255545916 223 IDNTDPAGIDHQIAQLGPElsSTLVIVISKSGGTPETRNGLLEVQKAFREA----------------GLEFAKQGVAITq 286 302773786 150 IDNTDPAGIDHQISQLGAKlsSTLVIVISKSGGTPETRNGLLEVQKAFREK----------------GLDFPKQAVAITq 213 302793418 157 IDNTDPAGIDHQISQLGAKlsSTLVIVISKSGGTPETRNGLLEVQKAFREK----------------GLDFPKQAVAITq 220
223997514 325 EAHAEAIKFGIDEQRI-FPIWDWTGGRFSVWSAAGMLPLSLHySFVvMRRFLEGAHDIDEHFFDSPLGGNIPILLGLIGV 403 115479643 292 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IKEMLVGAALMDEETRNTVVKENPAALLALCWY 369 115476914 291 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IKEMLVGAAQMDEETRNTEIKENPAALLALCWY 368 224063299 285 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IREMLAGAALMDEANRTTVLRNNPAALLALCWY 362 225459126 292 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IREMLAGASLMDEANRTTVVRNNPAALLALCWY 369 225459128 292 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IREMLAGASLMDEANRTTVVRNNPAALLALCWY 369 242049530 282 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IKEMLAGAALMDEETRTTVVKENPAALLALCWY 359 255545916 287 ENSLLDNTARIEGWLArFPMFDWVGGRTSEMSAVGLLPAALQ-GID-IREMLAGASLMDEANRTTVLRNNPAAMLALCWY 364 302773786 214 EKSLLDTTARSEGWLArFPMFDWVGGRTSELSAVGLLPAALQ-GIN-VDDMLYGAALMDKATRKQSIKENPAALLALCWY 291 302793418 221 EKSLLDTTARSEGWLArFPMFDWVGGRTSELSAVGLLPAALQ-GIN-VDDMLYGAALMDKATRKQSIKENPAALLALCWY 298
223997514 404 WNSTFMGYHTRALLPYSHALRRFPSLVQKFDSESNGKRVTAAGIplQFPAGEINFGESGTNGQHSFYQMLHQG-RPVPSD 482 115479643 370 WASEGIGNKDMVVLPYKDSLLLLSRYLQQLVMESLGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 447 115476914 369 WASDGIGS--------KDSLLLLSRYLQQLVMESLGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 438 224063299 363 WASEGVGSKDMVVLPYKDSLLLFSRYLQQLVMESLGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 440 225459126 370 WASEGVGSKDMVILPYKDSLLLFSRYLQQLVMESIGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 447 225459128 370 WASEGVGS--------KDSLLLFSRYLQQLVMESIGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 439 242049530 360 WATEGIGKKDMVVLPYKDSLLLLSRYLQQLVMESLGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 437 255545916 365 WASDGIGSKDMVVLPYKDSLLLFSRYLQQLVMESLGKEFDLDGN--RVNQGLTVYGNKGSTDQHAYIQQLREGvHNFFVT 442 302773786 292 WASNGIGSKDMVVLPYKDSLLLFSRYLQQLVMESLGKELDLDGN--LVNQGLSVYGNKGSTDQHAYIQQLREGvSNFFAT 369 302793418 299 WASNGIGSKDMVVLPYKDSLLLFSRYLQQLVMESLGKELDLDGN--LVNQGLSVYGNKGSTDQHAYIQQLREGvSNFFAT 376
223997514 483 FIGFMESQSSVDEEyisnqggnafdgwndKLEVSRHDELMSNFFAQPDALaygktlsdliqeevpeelrqhkvCPGNRPS 562 115479643 448 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YSNDRES 491 115476914 439 FIEVLRDRPPGHEWe-------------lEPSVTCGDYLFGMLHGTRSAL-----------------------YANDRES 482 224063299 441 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YAKDRES 484 225459126 448 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YAKDRES 491 225459128 440 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YAKDRES 483 242049530 438 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YANDRES 481 255545916 443 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YANDRES 486 302773786 370 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YANKRES 413 302793418 377 FIEVLRDRPPGHDWe-------------lEPGVTCGDYLFGMLQGTRSAL-----------------------YANKRES 420
223997514 563 SAILMTKLDAFALGQLLAIYEHRTVVQGFVWGINSFDQYGTEIGK-------VLAKRVRAQLSASRRRgASVQGFNSSSG 635 115479643 492 ISVTVQEVTPRAVGALVALYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLTVLNEASCK-DPAEPLTLDQI 570 115476914 483 ITVTVQEVNPRAVGALVALYERAVGLYAYLININAYHQPGVEAGKkaagevlALQKRILLVLNEASCK-DPAEPLTLDQI 561 224063299 485 ITVTVQEVTPRSVGALIGLYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLAVLNEASCK-QPVEPLTIEEV 563 225459126 492 VTVTVQEVTARSVGAMIALYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLAVLNEASCK-EPVEPLTLDEV 570 225459128 484 VTVTVQEVTARSVGAMIALYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLAVLNEASCK-EPVEPLTLDEV 562 242049530 482 ISVTVQEVTPRAVGALVALYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLTVLNEATCE-NPGEPLSIDEI 560 255545916 487 ITVTVQEVTPRTVGALVALYERAVGIYASLVNINAYHQPGVEAGKkaagevlALQKRVLAVLNEASCK-EPVEPLTLEEV 565 302773786 414 ITVTVQEVNARTIGALIALYERAVGLYASLVNINAYHQPGVEAGKkaaadvlALQKRVLAVLNEASCK-EPAEPLAVETI 492 302793418 421 ITVTVQEVNARTIGALIALYERAVGLYASLVNINAYHQPGVEAGKkaaadvlALQKRVLAVLNEASCK-EPAEPLAVETI 499
223997514 636 F--------------MLEAYLSHGRASR 649 115479643 571 AerchcpediemiykIIQHMAANDRALI 598 115476914 562 AdrchcpeeiemiykIIQHMAANDRALI 589 224063299 564 AdrchatediemiykIIAHMAANDRALI 591 225459126 571 AerchapediemiykIIAHMAANDRALI 598 225459128 563 AerchapediemiykIIAHMAANDRALI 590 242049530 561 AdrchcpediemiykIIQHMAANDRALI 588 255545916 566 AerchaeediemiykIILHMAANDRALI 593 302773786 493 AqlcqapnqvemiykIVLHMAANDRALF 520 302793418 500 AqlcqapnqvemiykIVLHMAANDRALF 527