2FU9,2QIN


Conserved Protein Domain Family
L1_POM-1-like_MBL-B3

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cd16289: L1_POM-1-like_MBL-B3 
Click on image for an interactive view with Cn3D
Stenotrophomonas maltophilia L1, Pseudomonas otitidis POM-1 and related metallo-beta-lactamases, subclass B3; MBL-fold metallo-hydrolase domain
MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of L1- and Pom-1-like MBLs belongs to the B3 subclass. Subclass B3 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile. These B3 enzymes have a modified Zn2/DCH site (Asp-His-His).
Statistics
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PSSM-Id: 293847
Aligned: 8 rows
Threshold Bit Score: 438.866
Created: 19-Aug-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:MP2 is also known as N-[(benzyloxy)carbonyl]-L-cysteinylglycine
  • Structure:2FU9: Stenotrophomonas maltophilia L1 metallo-beta-lactamase binds the inhibitor MP2 and two zinc ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #                                                                  # # ##       
2FU9_A     17 WLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAEL 96  Stenotrophomonas m...
KFN41690   14 WRQPVPPFALADSSWYIGTEGLSAVLVKTPDGAVLIDGGLPQAADMLLQRMRALGVAPADLKLILHSHAHIDHIGPLAAV 93  Arenimonas metalli...
AGC43911   42 WLKPMEPLRIADRTWQIGTEELTALLVETKDGLVLLDGGMPQMAEHLLANLKRRGFEPKDLRLILSSHAHTDHAGPFAEL 121 Myxococcus stipita...
KGM53724   39 WRQPVTPFKIADRTWYIGTAGLSALVVVGDAGTVLVDGGMPQAADMLLRNLRDVGIADGQLKWIVHSHAHADHSGPLAEV 118 Lysobacter daejeon...
ERP91498   29 WLAPMSPLPLADNVWHIGTEELTALLVKTADGAILIDGGMPQGADMLLDNMRTLGVAPEDLKWILVSHGHGDHAGSLAAI 108 Alcanivorax sp. P2S70
KGQ19624   43 WRQPIAPLQLADHTWYIGTESISAVLIVTPEGALLIDGGMPQAADMLLSNMRTVGVAPNQLRWLLVSHAHADHAGPVAAL 122 Lysobacter dokdone...
ADC79561   36 WLTPVAPLRIADNTWHIGTASITALLVKTPEGAVLLDGGMPQVADHLLANMRELGVAPGDLKLILHSHAHIDHVGPLAAI 115 Pseudomonas otitidis
2QIN_A     17 WLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHACHAGPVAEL 96  Stenotrophomonas m...
Feature 1                                #  ##                               #                
2FU9_A     97 KRrTGAKVAANAESAVLLARGGsDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGK 176 Stenotrophomonas m...
KFN41690   94 KRaTGARMVGSAESAVLLARGGgDDIHYGDELVFPPVAIDRIVMDGEVVSLGGMAFTAHFTPGHTPGSTSWTWQDQRDGQ 173 Arenimonas metalli...
AGC43911  122 KRrTGARVVASAESAVLLARGGsDDLHYGDSITFPPVVADRVVMDGEVVSQGGVEFTAHFMPGHTPGSIGWTWTDTRDGK 201 Myxococcus stipita...
KGM53724  119 QRaTGARVATNAESSVLLARGGsDDLHFGDSIAFPPVKADRMLLDGEAIDLGNVKLTAHFTPGHTPGSLSWTWTDTRDGK 198 Lysobacter daejeon...
ERP91498  109 QRaTGARLAANAETAMLMAAGGaHDIHFDDEILYPPVSVDRQLQDGEQVTLGEVTLTGHFIPGHTPGSMAWTWQARRQGK 188 Alcanivorax sp. P2S70
KGQ19624  123 KRaTGARIAANAESAAMLAKGGtDDIHFGDGITFPPAQVDRYLQDEEVVEVGAMRLTGHFTPGHTPGSTSWTWTDTKNGK 202 Lysobacter dokdone...
ADC79561  116 KKaTGAQLVSNAESAVLLQRGDsQDIHFGDDMVFAPVQVDRLVQDGETVELGGMTFTAHFTPGHTPGSLSWTWTDRRDGK 195 Pseudomonas otitidis
2QIN_A     97 KRrTGAKVAANAESAVLLARGGsDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGK 176 Stenotrophomonas m...
Feature 1               # #                                   #                              
2FU9_A    177 PVRIAYADSLSAPGYQLQGnprypHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGAraGAKALTCKAYADAAEQ 255 Stenotrophomonas ma...
KFN41690  174 PLRIAYVDSLSAPGYRLLEnprypRIVEDYRRTFAAVRALPCDLLLTPHPGASGWTPAETRapHARPMGCAAYADGAER 252 Arenimonas metalli ...
AGC43911  202 PVRIVYADSLSAPGYRLLGhprypRIVEDYRRSFATVRALPCDVLLTPHPGSSNWDYTAGAaaGAKAMSCKAYADSAEK 280 Myxococcus stipitat...
KGM53724  199 AVRIAYVDSLTAPGYDLIGharypRIVEDYRTTFAKVRALPCDVLITPHADASGWAPGTAMp-HAKSMTCRQYADRAEQ 276 Lysobacter daejeone...
ERP91498  189 TVDMAYVDSLTAPGYQLLDnprypRIVDDFNATFATVRALPCDVLLTPHPGASGWHYGDPA--RSSPLDCQRYADIAEQ 265 Alcanivorax sp. P2S70
KGQ19624  203 PVRFAYADSLSAPGYKLIEnarfpRIVETYKHTFEIVRGLPCDVLLTPHADGSGWTPADVAnpHPKPITCRQYADDFEA 281 Lysobacter dokdonen...
ADC79561  196 PLRIAYSDSLSAPGYSLWMnprfsKIAEAFRSGFAAVRALPCDLLITPHAEASGWDYTNAEhpNPSPMSCKAYADKAEA 274 Pseudomonas otitidis
2QIN_A    177 PVRIAYADSLSAPGYQLQGnprypHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGAraGAKALTCKAYADAAEQ 255 Stenotrophomonas ma...

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