1G6I,1FO3


Conserved Protein Domain Family
Glyco_hydro_47

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pfam01532: Glyco_hydro_47 
Glycosyl hydrolase family 47
Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
Statistics
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PSSM-Id: 460241
Aligned: 97 rows
Threshold Bit Score: 342.229
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1G6I_A        46 MFLESWRDYSKHGWGYDVYGPIEHTSHNMPrgnQPLGWIIVDSVDTLMLMynsstlyksEFEAEIQRSEHWINdVLDFD- 124  baker's yeast
XP_001584781  27 EFLRAWNGYKNNAWMHDEVMPLSGGQKDTF---VGWAATLVDSLDTLYIM---------GLKKEFEDALESLR-RIDFS- 92  
XP_001591293 203 EFLKSWKGYKKFAWGHDELSPVSTKFRDPF---CGWAATLVDGLDTLWIM---------GLYEEFEEAVKAVE-KIDFT- 268 
Q5KDN4       235 GFKHAWEAYKRHAWGHDEVRPVSLTHSDPF---NGWGATIVDSLDTLLLM---------GFSNEYNLCRPHVN-QLNFHw 301  Cryptococcus n...
Q5BBN5       107 AFKHAWKGYKSNAWLRDELSPLSGGYRTSF---AGWAATLVDALDTLIIM---------DLTDEFEEALEALE-HIDFS- 172  Aspergillus ni...
Q2UJG7       109 AFKHAWKGYKEHAWLRDELSPLSAEYRESF---GGWAATLVDSLDTLIIM---------GLMDEFEDALQAIE-HIDFS- 174  Aspergillus or...
CAK44699     103 AFQHAWKGYRNNAWLEDELSPISGGHRETF---AGWAATLVDSLDTLVIM---------GLTEEFEEAVKALE-YIDFT- 168 
Q4WPQ3       110 AFTHAWKGYKQHAWMRDELSPLSARYRTTF---AGWAATLVDALDTLVIM---------GMENEFKDALHAIE-SIDFT- 175  Aspergillus fu...
EDN93472     104 NFTHAWNGYVSHAWLKDEVMPLSGGSMDPF---GGWAASLVDTLDTLWIM---------GMHSQFKAAVEAIQ-VIDFS- 169 
EDN09338     103 AFLHSWKGYKKYAWLKDELSPVDGGGRNPY---GGWGATLVDTLDTLWLM---------GLEKEFKEAVAAVK-HIDFS- 168 
1G6I_A       125 --------------I-DA-EV-----------NVFETTIRMLGGLLSAYHLSdvleVGNKTVYLNKAIDLGDRLALAFlS 177  baker's yeast
XP_001584781  93 --------------KpNAeRV-----------PVFETTIRYLGGLLGAWDVS----GHQYPILLEKAKQLGDLLYQAF-N 142 
XP_001591293 269 --------------TtPRmEI-----------PVFETTIRYLGGLLAAFDVS----DGKFQVLLDKATELAEILMGAF-D 318 
Q5KDN4       302 vngrdwndgyvseeLsGSgEVyalnrdktvglAVFETGIRYLGGLLGAYDLS------GDDLLLERAVDLADILSTAF-K 374  Cryptococcus n...
Q5BBN5       173 --------------TtDSiQI-----------NVFETNIRYLGGLLGAHDLT----EGRYPILLKKATEIADFLYGSF-D 222  Aspergillus ni...
Q2UJG7       175 --------------TtGAtQI-----------NVFETNIRYLGGFLGAYDLT----NGSYPILLKKAVEVADLIYGSF-D 224  Aspergillus or...
CAK44699     169 --------------TtSAiQI-----------NVFETNIRYLGGLLGAYDLT----QGKYPILLKKAVEIADMIYGSF-D 218 
Q4WPQ3       176 --------------TpDAtQI-----------NIFETTIRYVGGLLGAYDLT----DGKHPILLKKAVELADMIYDAF-D 225  Aspergillus fu...
EDN93472     170 --------------TcALeQI-----------NVFETTIRYLGGFLSAYELS----GEKYPVLLQKATEMGEMLYKSF-D 219 
EDN09338     169 --------------SsDTsLL-----------NVFETNIRYLGGFLAAHDLT----KGAYPILLQKAVEVGDLLYVAF-D 218 
1G6I_A       178 TQTGIPYSSINLhsGQAVKN--HADGGASST-AEFTTLQMEFKYLAYLTGNRTYWELVERVYEPLYKNNdlL-NTYDGLV 253  baker's yeast
XP_001584781 143 TESGIPTPYYWWekELSEGE--KILGENGVLlAQIASLSIEFIRLSQVTGDQKYEKSIQKITDQLENIQ--NtTVLPGMW 218 
XP_001591293 319 TPNRMPVLHYRWkpVFASQP--HRASSRSNL-AELGSLSMEFTRLAQLTGEQRYYDAVARVTNALSEWQdrNsTYIPGVF 395 
Q5KDN4       375 TGSGLPAGRMD----PGTKD--EMIRLGTVSlAEVGSMSLELIRLSQITKDRKWFDLAQRAMDYIHERVi-PrGTHSPLI 447  Cryptococcus n...
Q5BBN5       223 TRNRMPQSRWEWtrSASGQT--IHPSGNTIL-AELGSLNLEFTRMSQLTGDQKYFDAIQRISDHLESAQ--KeTLVPGLW 297  Aspergillus ni...
Q2UJG7       225 TRNRMPQSRWEWtrSALGMG--IQPSRNTIL-AELGSLNLEFTRMSQLTKDPKYFDAIQRITDKLESAQ--SrTQVPGLW 299  Aspergillus or...
CAK44699     219 TRNRMPQSRWEWtrSADGLS--IEPGRNTIL-AELGSLNLEFTRLSQLTKDPKYFDAIQRIADFLEDTQ--EtTDVPGMW 293 
Q4WPQ3       226 TTNRMPQSRWQWs-RS-ARGlsIQPSRQTIL-AELGSLNLEFTRLSQLTHDPKYFDAVQRITNVLDDAQ--NkTKIPGLW 300  Aspergillus fu...
EDN93472     220 TPNHLPILRWYYhiAATGAK--QEADDNVLE-SEIGSLTLEFTRLGQITGDPRFYDAVQRIMNIFDEQQ--SmSKLPGMW 294 
EDN09338     219 TPNRMPVLRWYWhgARDGYH--QEASMLTVL-AEFGSLSLEFTRLSQITGDPKYYDAIQRITTILQEHQ--FnTKVPGLW 293 
1G6I_A       254 PIYTFPDTGKFG-A------------------------------------------------------------------ 266  baker's yeast
XP_001584781 219 PSQVNCMGSNLAsAs----------------------------------------------------------------- 233 
XP_001591293 396 TEEVDASGCNRT-Atlikqnekkeaalaketalsdpetaalldeapegykppspeteikgsksrkkprpgdkmlemqvlp 474 
Q5KDN4       448 PMWFQPDAPLTTsMh----------------------------------------------------------------- 462  Cryptococcus n...
Q5BBN5       298 PMMVDAESMRFSd------------------------------------------------------------------- 310  Aspergillus ni...
Q2UJG7       300 PMMVDAHDMQFTd------------------------------------------------------------------- 312  Aspergillus or...
CAK44699     294 PMMVNAKDLEFAd------------------------------------------------------------------- 306 
Q4WPQ3       301 PMMVNAEDLEFT-D------------------------------------------------------------------ 313  Aspergillus fu...
EDN93472     295 PVIVNAKDKNFV-Dy----------------------------------------------------------------- 308 
EDN09338     294 PVSVDARTPSFE-Rd----------------------------------------------------------------- 307 
1G6I_A           --------------------------------------------------------------------------------      baker's yeast
XP_001584781     --------------------------------------------------------------------------------     
XP_001591293 475 gepgkahikgwgdgnakkrdlgesalsasttvsttpppaanhppnhppvyrngnglghsfapelpdlpgtggagdwdcvk 554 
Q5KDN4           --------------------------------------------------------------------------------      Cryptococcus n...
Q5BBN5           --------------------------------------------------------------------------------      Aspergillus ni...
Q2UJG7           --------------------------------------------------------------------------------      Aspergillus or...
CAK44699         --------------------------------------------------------------------------------     
Q4WPQ3           --------------------------------------------------------------------------------      Aspergillus fu...
EDN93472         --------------------------------------------------------------------------------     
EDN09338         --------------------------------------------------------------------------------     
1G6I_A       267 -----------STIRFGSRGDSFYEYLLK---------QYLLT--H----ETLYYDLYRKSMEGMKKH-LLA-QSKPS-- 316  baker's yeast
XP_001584781 234 -----------LSFTLGAFADSAYEYLPK---------THLILpkSs--sADQYLRMYRNVLSTINKHlVFR-PNLPGdp 290 
XP_001591293 555 qgleaytqggrQKFSMGGGQDSTYEYYPK---------QYMLL--Gg--lEEVYRKMYMKTIPAIRDYmLFR-PMVPGdd 620 
Q5KDN4       463 -----------GGLTFGGLADSYYEYLIK---------TYKLL--GtsevSQVWRDVYERSIDKAKETlYVDiDIVPGr- 519  Cryptococcus n...
Q5BBN5       311 -----------PRYTIGGMADSAYEYLPK---------EHMLL--Eg--rTQQYQRMYESAIPAIKERmLFR-PMTKGge 365  Aspergillus ni...
Q2UJG7       313 -----------PRFTVGGMADSTYEYLPK---------EHILL--Ga--qTDQYRKMYDAAINSIKKRlLFR-GMTKDgk 367  Aspergillus or...
CAK44699     307 -----------PRFTIGGMADSTYEYLPK---------EHMLL--Gg--qTNQYRRMYNSFMKAMKSRlLFR-PMTEDgr 361 
Q4WPQ3       314 -----------PRFTVGGMADSTYEYLPK---------EHMLL--Ga--rTDQYRKMYAAAMEAIKKRlLFR-PMTKNge 368  Aspergillus fu...
EDN93472     309 -----------WGFTIGGMADSLYEYLPK---------QHLLL--Gg--aTQQYRRMYEYAMIAMRRNiFFR-PMTKNge 363 
EDN09338     308 -----------RRFTFGGMADSLYEYLPKvrsyyryklEYLLL--Gg--rNQQYKDMYEKALEVAKKHiFFR-PMTKDsd 371 
1G6I_A       317 SLWYIGEREQG-----LQGQLSPKMDHLVCFMGGLLASGSTEGlSIhearrrpffsKSDWDLAKGITDTCYQMYKQSSSG 391  baker's yeast
XP_001584781 291 DILFTGT-VDVd---sGQPILDAQIQHLACFTGGMIGIGSRIN-QS----------PSEMETAIKLTNGCIWAYENTPSG 355 
XP_001591293 621 DILISGKVTSTgd--mEENLLIPEVTHLTCFIGGMVGMSAKIF-GI----------EGDLEIAKKLTDGCVWAYGATPLG 687 
Q5KDN4       520 NILAVGKL--------ENGRLIPELEHLTCFIGAMLGLGAKLL-DR----------PGDMRDAERVTASCYWLSADTPTG 580  Cryptococcus n...
Q5BBN5       366 DILFSGNIYAGtk--aSRKKVEAQAEHLKCYLGGTIGIGAKVF-NR----------PEELSIARKLTDGCIWAYDIMPSG 432  Aspergillus ni...
Q2UJG7       368 DIMFAGNIRST-----SKSVIEPQFEHLKCFLGGTVGIGAKVF-DR----------PEELSIARKLTDGCIWAYDIMPTG 431  Aspergillus or...
CAK44699     362 DILFAGNLRVTgs--sTRSNLEPQWEHLKCYLGGTVGIGSKVF-DR----------PEDLAVARKLVDGCIWAYDIMPTG 428 
Q4WPQ3       369 DLLFAGNTHTGl---aSNAPPEPQWEHLKCFFGGTVGIGAKIF-NR----------PEELSIARKLTDGCIWAYDVMPTG 434  Aspergillus fu...
EDN93472     364 DIRLPGNVDSDgktlvTELKTQGEAQHLGCFAGGMVAIGAKIF-EN----------EKDLELARKLTEGCLWAYENMPLG 432 
EDN09338     372 DILISGTAFIAg---tTRVTLRPQGQHLTCFVGGMVALAAKVF-SR----------PEELDIARKLTEGCIWAYKATPSG 437 
1G6I_A       392 LAPEIVVFN----DGNi-------------kQDGWWRSSVGDFFVK---------------------------------- 420  baker's yeast
XP_001584781 356 IMPEIFHVD----PCTn-------------iSSCKFQGSNTDNgf----------------------------------- 383 
XP_001591293 688 IMPEGSEVI----ACEs-------------vEHCSWNQTLYYERLDpsahyrdanlkeyienkekldaeakdmnmspmda 750 
Q5KDN4       581 LQPEVVEWYapheTSAmyenvsisgggrhhpLIFSEDESKDRDGMYrdrngvlrwtednepvlytdrek----------- 649  Cryptococcus n...
Q5BBN5       433 IMPEVMYLS----PCDd-------------lENCPWDEQKWYRDVRarppphaniadteeaa------------------ 477  Aspergillus ni...
Q2UJG7       432 IMPEALYIS----PCKn-------------tDDCEWDEQKWHTDVLrrfaknsqgeevaq-------------------- 474  Aspergillus or...
CAK44699     429 IMPEILHLT----VCKd-------------dENCQLPQSSHPTSTSkdgkkl---------------------------- 463 
Q4WPQ3       435 IMPESMHLS----PCQs-------------mDHCEWDEQKWYQDVRrrlakgskekdtvqea------------------ 479  Aspergillus fu...
EDN93472     433 IMAEKMHMV----PCEn-------------eNYCPWDEQKWLEGINkdtegnetvnek---------------------- 473 
EDN09338     438 VMPETFEVV----PCEd-------------sRDCKWRPESWFIGEIhegasdsdyerm---------------------- 478 
1G6I_A           --------------------------------------------------------------------------------      baker's yeast
XP_001584781     --------------------------------------------------------------------------------     
XP_001591293 751 dreqnalakaktvggpqgytghretdslkkdsleiksndagafkpkdepasltkrqshadtmdgpekqtmfeqksaktka 830 
Q5KDN4           --------------------------------------------------------------------------------      Cryptococcus n...
Q5BBN5           --------------------------------------------------------------------------------      Aspergillus ni...
Q2UJG7           --------------------------------------------------------------------------------      Aspergillus or...
CAK44699         --------------------------------------------------------------------------------     
Q4WPQ3           --------------------------------------------------------------------------------      Aspergillus fu...
EDN93472         --------------------------------------------------------------------------------     
EDN09338         --------------------------------------------------------------------------------     
1G6I_A       421 ---------------------------------------------------PLDRHNLQRPETVESIMFMYHLSHDHKYR 449  baker's yeast
XP_001584781 384 -------------------------------------------------trIEDPSYQLRPEAIESIFIMYRLTGDPVWQ 414 
XP_001591293 831 elesmaggrqlekgqkplgseslpdplrplshkeyvesrikqeslppgftsIFTRKYILRPEAIESVWYMYRITGDKSWQ 910 
Q5KDN4       650 -----------------------------kkngqtpikyaqrlkgtptgarKVSTRGLNRPETIESIFYMYRITGDRKWQ 700  Cryptococcus n...
Q5BBN5       478 ------------------------------------klliekfdlvpgvaeIADARYMLRPEAIESVFIMYRITGDKKYQ 521  Aspergillus ni...
Q2UJG7       475 -------------------------------------qiissnklppgvteIPDASYNLRPEAIESVFIMYRITGDKELQ 517  Aspergillus or...
CAK44699     464 ---------------------------------------------ppgvvdIPDPKYLLRPEAIESVFIMYRITGDRSLQ 498 
Q4WPQ3       480 ------------------------------------ktiirdsglqpglteITDPRYLLRPEAIESVFIMYRITGDKKLQ 523  Aspergillus fu...
EDN93472     474 ---------------------------------------iqqhrlipgvtkFDDGRYILRPEAIESVFILYRITGDPDLQ 514 
EDN09338     479 ---------------------------------------greqgkvagfsaIIHGGYSLRPEAIESVFILYRITGDKTLQ 519 
1G6I_A       450 EWGAEIATSFFENTCVdCNdpklrRFTSLSDCITL-PTKKSNNMESFWLAETLKYLYILFLDE--FDLTKVVFNTEAHPF 526  baker's yeast
XP_001584781 415 EKGWKMFNAIVKHTHT-DI-----ANARIKNVMDE-KPEKEDSMESFWLAETLKYFYLLFCEPgvLSLDEWVLNTEAHPL 487 
XP_001591293 911 EKGWKMYEAVINATST-EF-----GNSAIYDVTAE-EAYRIDEMESFWLAETLKYFYLLFSTPetISLDEWVLNTEAHPF 983 
Q5KDN4       701 EKGWKMFTSWMNASTV-DG-----GFSSVEDVTKL-PVRFGDNMESFALAETFKYHFLLQSEPdvLSLDDYVLNTEAHPF 773  Cryptococcus n...
Q5BBN5       522 DAAWRMFNSIEKATRT-KY-----AHAAINDVREE-KPKQLDYMESFWLAETLKYFYLIFSEPelISLDDYVLNTEAHPF 594  Aspergillus ni...
Q2UJG7       518 DAAWRMFRSIEKMTLT-RY-----GHAAISDVRNP-QSSQLDYMESFWLAETLKYFYLIFSEPdvVNLDEYVLNTEAHPF 590  Aspergillus or...
CAK44699     499 DAAWRMFQNIDKMTRT-SF-----GHAAISDVRDP-ESPQMDYMESFWLAETLKYFYLIFSEPdlVNLDEYVLNTEAHPF 571 
Q4WPQ3       524 DDAWRMFQSIEKATRT-KY-----AHAAIDDVRDV-KATQLDYMESFWLAETLKYFYLIFSEPglVSLDDYVLyvllsye 596  Aspergillus fu...
EDN93472     515 ERAWTMFNNIIKHTIT-DI-----AHAALDDCTVSeNPRKADRMESFWMAETLKYFYLIFADPdlISLDEYVLNTEAHPL 588 
EDN09338     520 DKGWEMFFAIEKHAKT-EF-----AYGGLDDVASP-NPTITNRMESFWTGETLKYFYLLFSEPdlASLDNTLI---AHGL 589 
1G6I_A       527 P 527  baker's yeast
XP_001584781 488 R 488 
XP_001591293 984 K 984 
Q5KDN4       774 L 774  Cryptococcus neoformans
Q5BBN5       595 K 595  Aspergillus nidulans
Q2UJG7       591 R 591  Aspergillus oryzae
CAK44699     572 K 572 
Q4WPQ3       597 v 597  Aspergillus fumigatus
EDN93472     589 K 589 
EDN09338     590 G 590 
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