4P0L,1MD6,4P0K,4P0J


Conserved Protein Domain Family
beta-trefoil_IL36RA

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cd23303: beta-trefoil_IL36RA 
beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar proteins
IL-36RA, also called FIL1 delta, or IL-1-related protein 3, or IL-1RP3, or interleukin-1 HY1, or IL-1HY1, or interleukin-1 delta, or IL-1 delta, or interleukin-1 family member 5, or IL-1F5, or interleukin-1 receptor antagonist homolog 1, or IL-1ra homolog 1, or interleukin-1-like protein 1, or IL-1L1, inhibits the activity of interleukin-36 (IL36 alpha,IL36 beta and IL36 gamma) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. It is part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which it shares the coreceptor. It may play a role in skin inflammation, as well as in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. It may activate an anti-inflammatory signaling pathway by recruiting SIGIRR. IL-36RA contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 466785
Aligned: 11 rows
Threshold Bit Score: 260.826
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P0L_A         4 GALCFRMKDSALKVLYLHNNQLLAGGlhagkviKGEEISVVPNRwpealeqgrGSPVILGVQGgSQCLSCGvGQEPTLTL 83  human
1MD6_A         4 GALCFRMKDSALKVLYLHNNQLLAGGlhaekviKGEEISVVPNRald----asLSPVILGVQGgSQCLSCGtEKGPILKL 79  house mouse
4P0K_A         4 GALCFRMKDSALKVLYLHNNQLLAGGlhagkviKGEEISVVPNRwpealeqgrGSPVILGVQGgSQCLSCGvGQEPTLTL 83  human
4P0J_A         4 GALCFRMKDSALKVLYLHNNQLLAGGlhagkviKGEEISVVPNRwld----asLSPVILGVQGgSQCLSCGvGQEPTLTL 79  human
Q9UBH0         5 GALCFRMKDSALKVLYLHNNQLLAGGlhagkviKGEEISVVPNRwld----asLSPVILGVQGgSQCLSCGvGQEPTLTL 80  human
XP_001376850   5 GALCFRMKDTAMKVLYVQNNQLLAGKvragkniDGEKISVVPNRsld----skLIPIILGFEGgTQCLSVGiTQQPILQI 80 
XP_030407643  58 QPFHYQIRDTSHKAFYLRDNSLVAANlqgenasQEEMVSVVPNRtle----rkRCPLILGIKGgSQGLSCGtAEQPQLQL 133 Goodes thornscr...
TFJ97238      93 GPSLFTLRDTSQKVIRFHHNRLVASPqta--naSPEKISVVPNQfmd----prHFPIIMGIDGgTRCLSCGtSAQPTLML 166 big-headed turtle
KYO25690     304 SPAPFILRDVKQKVVCLRAKNLVAVQdds--naAADTISVVPNQfmd----rgNYPIIMGVEDgNHCLSCGtASEPQLQL 377 American alligator
CCE26532      26 QPYHYAVRDTEHKGLCLRDGRLVATNlqgvnaeQEEPISVVPNPhle----rrRCPLIVGIRGgNKALSCGtGPEPRLQL 101 chicken
Q9QYY1         6 GALCFRMKDSALKVLYLHNNQLLAGGlhaekviKGEEISVVPNRald----asLSPVILGVQGgSQCLSCGtEKGPILKL 81 
4P0L_A        84 EPVNIMELYlgaKESKSFTFYRADAGLTSSFESAAYPGWFLCTVPEadQPVRLTQElg----ksYNTDFYFQQC 153 human
1MD6_A        80 EPVNIMELYlgaKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEadQPVRLTQIpedpawdaPITDFYFQQC 153 house mouse
4P0K_A        84 EPVNIMELYlgaKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEadQPVRLTQElg----ksYNTDFYFQQC 153 human
4P0J_A        80 EPVNIMELYlgaKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEadQPVRLTQElg----ksYNTDFYFQQC 149 human
Q9UBH0        81 EPVNIMELYlgaKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEadQPVRLTQLpenggwnaPITDFYFQQC 154 human
XP_001376850  81 EHRNIMDLYqskEESRSFTFYRWDAGITSRLESAAYPGWFLCTILEedQPITLTNHped--shsVIADFYLEQC 152
XP_030407643 134 EDMHLIDLFyqdEEAKRFTFFKTYNGSTHRFEAAAYPGWFLCTSTQanEPISLTTRlg----etAITDFYFQPK 203 Goodes thornscrub tor...
TFJ97238     167 EDKKIMDLYqnsREAERFTFTCSATGSTHRFESVAFPGWYLSTSPRndQPLRVTNRlg----eaEITNFYFKKV 236 big-headed turtle
KYO25690     378 ENKHIMTISnsqSDASRFTFFNTPQGNTHHFESAAYPGWFLCTSQKsnEPVSLTNQlg----qvNITDFYFSRK 447 American alligator
CCE26532     102 EEVKLLDLFssgDAAVPYTFYKTFGGTTHTFEAAAFPGHFLSTAPQpdRELGLAPRaa----pgSITSFYLRRR 171 chicken
Q9QYY1        82 EPVNIMELYlgaKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEadQPVRLTQIpedpawdaPITDFYFQQC 155
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