3IBD,2Q6N,5E58,5E0E,5UFG,4ZV8,1SUO,6BWW,4MGJ


Conserved Protein Domain Family
CYP2B

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cd20672: CYP2B 
Click on image for an interactive view with Cn3D
cytochrome P450 family 2, subfamily B
The human cytochrome P450 family 2, subfamily B (CYP2B) consists of only one functional member CYP2B6, which shows broad substrate specificity and plays a key role in the metabolism of many clinical drugs, environmental toxins, and endogenous compounds. Rodents have multiple functional CYP2B proteins; mouse subfamily members include CYP2B9, 2B10, 2B13, 2B19, and 2B23. CYP2B enzymes are highly inducible by chemicals that interact with the constitutive androstane receptor (CAR) and/or pregnane X receptor (PXR), such as rifampicin and phenobarbital. The CYP2B subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410765
Aligned: 23 rows
Threshold Bit Score: 848.68
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:3IBD: Human cytochrome P450 2B6 binds heme; contacts at 4A
  • Structure:5E58: Neotoma lepida cytochrome P450 2B35 binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #              ##      #   #                
3IBD_A        43 YGDVFTVHlgpRPVVMLCgVEAIREALVDKAEAFSGRGKIAMVDPffrgYGVIFANGNRWKVLRRFSVTTMRDFgmgkrs 122 human
5E0E_A        34 YGDVFTVHlgpRPVVMLYgTEAIREALVDQAEAFSGRGTIAVVEPifrgYGVVFANGERWKALRRFSLVTMRDFgmgkrs 113 desert woodrat
O55071        63 YGDVFTVHlgpRPVVMLCgTDTIREALVNQAEAFSGRGTVAVLDPivqgYGVIFSSGERWKTLRRFSLATMRDFgmgkrs 142 house mouse
P00176        62 YGDVFTVHlgpRPVVMLCgTDTIKEALVGQAEDFSGRGTIAVIEPifkeYGVIFANGERWKALRRFSLATMRDFgmgkrs 141 Norway rat
P04167        62 YGDVFTVHlgpRPVVMLCgTDTIKEALVGQAEDFSGRGTIAVIEPifkeYGVIFANGERWKALRRFSLATMRDFgmgkrs 141 Norway rat
P12790        62 HGDVFTVHlgpRPVVVLCgTQTIREALVDHAEAFSGRGTIAAAQLvmqdYGIFFASGQRWKTLRRFSLATMKEFgmgkrs 141 house mouse
P33272        63 YGDVFTVHlgpRPVVILCgTDTIREALVDQAEAFSGRGTVAVLHPvvqgYGVIFATGERWKTLRRFSLVTMKEFgmgkrs 142 Norway rat
Q64583        63 YGDVFTVHlgpRPVVILCgTDTIREALVDQAEAFSGRGTVAVLHPvvqgYGVIFANGERWKILRRFSLVTMRNFgmgkrs 142 Norway rat
P12791        62 YGDVFTVHlgpRPVVMLCgTDTIREALVGQAEAFSGRGTVAVVEPtfkeYGVIFANGERWKTLRRFSLATMRDFgmgkrs 141 house mouse
NP_001074617  62 HGDVFTVHlgpRPVVMLYgTETIKEALVDHSDAFSGRGAIAVIQPivqdYGVIFSSGERWKTLRRFSLATMRDFgmgkrs 141 Mus musculus
Feature 1                                             #                                          
3IBD_A       123 vEERIQEEAQCLIEELRKSkgalmdPTFLFQSITANIICSIVFGKRFHYqdQEFLKMLNLFYQTFSLISsvfgqlfelfs 202 human
5E0E_A       114 vEERIQEEARCLVEEFRKSqgapldPTFLFQCITANIICSIVFGERFDYkdHQFLRLLYLFYQSFSLISsfssqvfelfs 193 desert woodrat
O55071       143 vEERIKEEAQCLVEELKKYkgaplnPTFYFQCIVANIICSIVFGERFDYkdHQFLHLLNLIYQTFSLMSslssqvfelfs 222 house mouse
P00176       142 vEERIQEEAQCLVEELRKSqgapldPTFLFQCITANIICSIVFGERFDYtdRQFLRLLELFYRTFSLLSsfssqvfeffs 221 Norway rat
P04167       142 vEERIQEEAQCLVEELRKSqgapldPTFLFQCITANIICSIVFGERFDYtdRQFLRLLELFYRTFSLLSsfssqvfeffs 221 Norway rat
P12790       142 vEERIKEEAQCLVEELKKYqgvpldPTFLFQCITANIICSIVFGERFDYtdDQFLHLLNLMYKIFSLLSsfsgqmfelfs 221 house mouse
P33272       143 vDERIKEEAQCLVEELKKYkgaplnPTFLFQSIAANTICSIVFGERFDYkdHQFLHLLDLVYKTSVLMGslssqvfelys 222 Norway rat
Q64583       143 vEERIKEEAQCLVEELKKYkgallnPTSIFQSIAANIICSIVFGERFDYkdHQFLRLLDLIYQTFSLMGslssqvfelfs 222 Norway rat
P12791       142 vEERIQEEAQCLVEELRKSqgapldPTFLFQCITANVICSIVFGERFEYtdRQFLRLLELFYQTFSLISsfssqmfelfs 221 house mouse
NP_001074617 142 vEERIKEEAQCLVEELKKYegapldPTFLFQCITANIICSIVFGERFDYtdHQFLHLLDLFYQTLSLISsfssqlfelfs 221 Mus musculus
Feature 1                                                                                    ##  
3IBD_A       203 gflkhfpgaHRQVYKNLQEINAYIGHSVEKHretldpsapRDLIDTYLLHMekeksnahsefSHQNLNLNTLSLFFAGTE 282 human
5E0E_A       194 gflkyfpgtHRQISRNLQEILDYIGQSVEKHratldpshpRDFIDTYLLRMekeksnqhtefDHQNLVISVLSLFFAGTE 273 desert woodrat
O55071       223 ailkyfpgaHRQISKNLQEILDYIGHSVEKHratldpsapRDFIDTYLLRMekeksnhhtefHHQNLVISVLSLFFAGTE 302 house mouse
P00176       222 gflkyfpgaHRQISKNLQEILDYIGHIVEKHratldpsapRDFIDTYLLRMekeksnhhtefHHENLMISLLSLFFAGTE 301 Norway rat
P04167       222 gflkyfpgaHRQISKNLQEILDYIGHIVEKHratldpsapRDFIDTYLLRMekeksnhhtefHHENLMISLLSLFFAGTE 301 Norway rat
P12790       222 gflkyfpgvHRQIVKKQQELLDYIAHSVEKHkatldpsapRDYIDTYLLRMekeksnhntefHHQNLMMSVLSLFFAGTE 301 house mouse
P33272       223 gflkyfpgaHKQIFKNLQEMLNYIGHIVEKHratldpsapRDFIDTYLLRMekeksnhhtefNHQNLVISVLSLFFAGTE 302 Norway rat
Q64583       223 gflkyfpgvHKQISKNLQEILNYIDHSVEKHratldpntpRDFINTYLLRMekeksnhhtefHHQNLVISVLSLFFTGTE 302 Norway rat
P12791       222 gflkyfpgaHRQISKNLQELLDYIGHSVERHkatldpsvpRDFIDIYLLRMekeksnqnaefHHQNLMMSVLSLFFVGTE 301 house mouse
NP_001074617 222 avlkyfpgtHRQISKNIQEILNYIGHSVEQHkatldpsapRDFIDTYLLRMekeksnhhtefHHQNLLISVLSLFFAGTE 301 Mus musculus
Feature 1        ##  #                                                  #     #   # #            
3IBD_A       283 TTSTTLRYGFLLMLKYPHVAERVYREIEQvigphrppelhdrakMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYI 362 human
5E0E_A       274 TSSTTLRYGFLLMLKYPHVAEKVQKEIDQvigshrlptledrtkMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYL 353 desert woodrat
O55071       303 TTSTTLRYSFLIMLKYPHVAEKVQKEIDQvigshrlptlddrtkMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYL 382 house mouse
P00176       302 TSSTTLRYGFLLMLKYPHVAEKVQKEIDQvigshrlptlddrskMPYTDAVIHEIQRFSDLVPIGVPHRVTKDTMFRGYL 381 Norway rat
P04167       302 TGSTTLRYGFLLMLKYPHVTEKVQKEIDQvigshrppslddrtkMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYL 381 Norway rat
P12790       302 TTSATLHYGVLLMLKYPHVTEKVQKEIDQvigshrlptlddrtkMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFRGYL 381 house mouse
P33272       303 TTSTTLRCTFLIMLKYPHVAEKVQKEIDQvigshrlptpddrtkMPYTDAVIHEIQRFADLTPIGLPHRVTKDTVFRGYL 382 Norway rat
Q64583       303 TTSTTLRYSFLIMLKYPHVAEKVQKEIDQvigshrlptlddrtkMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMFLGYL 382 Norway rat
P12791       302 TSSTTLHYGFLLMLKYPHVTEKVQKEIDQvigshrlptlddrtkMPYSDAVIHEIQRFSDLIPIGVPHRVTKDTLFRGYL 381 house mouse
NP_001074617 302 TTSTTLRYGFLLMLKYPHVAEKVQKEIDQvisahhvptledrikMPYTEAVIHEIQRFSDLAPIGLPHTVTKDTVFRGYL 381 Mus musculus
Feature 1                  #                                   ###            # ###  ##          
3IBD_A       363 IPKDTEVFLILSTALhDPHYFeKPDAFNPDHFldangaLKKTEafIPFSLG---------KRICLGEGIARAELFLFFTT 433 human
5E0E_A       354 LPKNTEVYPILSSALhDPQYFeQPDTFNPDHFldangaLKKSEafMPFSIG---------KRICLGEGIARNELFLFFTT 424 desert woodrat
O55071       383 IPKNTEVYPILSSALhDPRYFeQPDSFNPEHFldangaLKTNEafMPFSTG---------KRICLGEGIARNELFLFFTT 453 house mouse
P00176       382 LPKNTEVYPILSSALhDPQYFdHPDSFNPEHFldangaLKKSEafMPFSTG---------KRICLGEGIARNELFLFFTT 452 Norway rat
P04167       382 LPKNTEVYPILSSALhDPQYFdHPDTFNPEHFldadgtLKKSEafMPFSTG---------KRICLGEGIARNELFLFFTT 452 Norway rat
P12790       382 LPKNTEVYPVLSSALhDPQYFeQPDKFNPEHFldangaLKKCEafLPFSTG---------KRICLGESIARNELFIFFTT 452 house mouse
P33272       383 LPKNTEVYPILSSALhDPRYFeQPDTFNPEHFldangaLKKSEafLPFSTG---------KRICLGEGIARNELFIFFTA 453 Norway rat
Q64583       383 LPKNTEVYPILSSALhDPRYFdHPDTFNPEHFldvngtLKKSEafLPFSTG---------KRICLGEGIAQNELFIFFTA 453 Norway rat
P12791       382 LPKNTEVYPILSSALhDPQYFeQPDSFNPDQFldangaLKKSEafLPFSTGqifdqksvgKRICLGESIARSELFLFFTS 461 house mouse
NP_001074617 382 LPKNTEVYPILSSALhDPQYFeQPDKFNPEHFldangaLKKSEafLPFSTG---------KRICLGEGIARNELFLFFTA 452 Mus musculus
Feature 1                                          
3IBD_A       434 ILQNFSmaspvapEDIDLTPQecGVGKIPPTYQI 467 human
5E0E_A       425 ILQNFSlsspvapKDIDLSPKesGFGKVPQTYQI 458 desert woodrat
O55071       454 ILQNFSlaspvapENIDLIPNnsGATKTPPQYQI 487 house mouse
P00176       453 ILQNFSvsshlapKDIDLTPKesGIGKIPPTYQI 486 Norway rat
P04167       453 ILQNFSvsshlapKDIDLTPKesGIAKIPPTYQI 486 Norway rat
P12790       453 ILQNFSvaspvapKDIDLTPKesGIGKIPPAHQI 486 house mouse
P33272       454 ILQNFTlaspvapEDIDLTPIniGVGKIPSPYQI 487 Norway rat
Q64583       454 ILQNFSlaspvapEDIDLSPInsGISKIPSPYQI 487 Norway rat
P12791       462 ILQNFSvashvapKDIDLTPKesGIGKIPPTYQI 495 house mouse
NP_001074617 453 LLQNFSlsspvapEDIDLTPKesGFVKIPPVYRI 486 Mus musculus

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